Crystalline compounds

ABSTRACT

The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.

This application is a continuation of U.S. patent application Ser. No. 15/611,580 filed Jun. 1, 2017 (now U.S. Pat. No. 9,856,217), which is a continuation of U.S. patent application Ser. No. 15/186,415 filed Jun. 17, 2016 (now U.S. Pat. No. 9,708,261), which claims priority to U.S. Provisional Application No. 62/181,174 filed Jun. 17, 2015, the contents of each of which are hereby incorporated by reference.

FIELD OF THE INVENTION

The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.

BACKGROUND OF THE INVENTION

(1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane, also known as (+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane, is a compound useful as an unbalanced triple reuptake inhibitor (TRI), most potent towards norepinephrine reuptake (NE), one-sixth as potent towards dopamine reuptake (DA), and one-fourteenth as much towards serotonin reuptake (5-HT). This compound and its utility are disclosed in more detail in U.S. Patent Publication No. 2007/0082940, the contents of which are hereby incorporated by reference in their entirety.

Active pharmaceutical ingredients can exist in different physical forms (e.g., liquid or solid in different crystalline, amorphous, hydrate, or solvate forms), which can vary the processability, stability, solubility, bioavailability, pharmacokinetics (absorption, distribution, metabolism, excretion, or the like), and/or bioequivalency of the active pharmaceutical ingredient and pharmaceutical compositions comprising it. Whether a compound will exist in a particular polymorph form is unpredictable. It is important in pharmaceutical development to generate and identify advantageous physical forms (e.g., free base or salt in solid, liquid, crystalline, hydrate, solvate, or amorphous forms) of active pharmaceutical ingredients. Therefore, there remains a need for particular polymorph forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane.

SUMMARY OF THE INVENTION

(1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane, also known as (+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane (“the Compound”) is shown as Formula I below:

The inventors have found particular polymorphs of the Compound in hydrochloric acid addition salt form. These particular polymorphs have different stability and dissolution profiles and are especially advantageous in the preparation of galenic formulations of various and diverse kind, especially Crystalline Form A as described below. Therefore, in the first aspect, the invention provides crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride, e.g.:

-   -   1.1 Crystalline Form A of the Compound in hydrochloric acid         addition salt form         ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride) (“Crystalline Form A”).     -   1.2 Formula 1.1 wherein the Crystalline Form A belongs to the         P2₁2₁2₁ space group and has the following unit cell parameters:     -    a=5.7779(2) Å, b=8.6633(2) A, c=25.7280(8) A, α=β=γ=90°.     -   1.3 Formula 1.1 wherein the Crystalline Form A belongs to the         P2₁2₁2₁ space group and has any combination of the following         unit cell parameters:     -    a=5-7 Å, e.g., 6 Å, e.g., 5.6-5.9 Å, e.g., 5.7-5.8 Å, e.g., 5.8         Å, e.g., 5.78, e.g., 5.778 Å;     -    b=8-10 Å, e.g., 9 Å, e.g., 8.5-8.8 Å, e.g., 8.6-8.7 Å, e.g.,         8.7 Å, e.g., 8.66 Å, e.g., 8.663 Å;     -    c=25-27 Å, e.g., 26 Å, e.g., 25.6-25.9 Å, e.g., 25.7-25.8 Å,         e.g., 25.7-25.8 Å, e.g., 25.73 Å, e.g., 25.728 Å; and     -    α=β=γ=90°.     -   1.4 Any of formulae 1.1-1.3 wherein the Crystalline Form A has a         calculated volume of V=1287.83(7) Å³.     -   1.5 Any of formulae 1.1-1.4 wherein the crystal structure of the         Crystalline Form A is obtained with a crystal having approximate         dimensions of 0.38 mm×0.30 mm×0.18 mm, e.g., a colorless plate         having approximate dimensions of 0.38 mm×0.30 mm×0.18 mm.     -   1.6 Any of formulae 1.1-1.5 wherein the crystal structure of the         Crystalline Form A is obtained with Mo Kα radiation, e.g., Mo Kα         radiation having λ=0.71073 Å.     -   1.7 Any of formulae 1.1-1.6 wherein the crystal structure of the         Crystalline Form A is obtained at 150 K.     -   1.8 Any of formulae 1.1-1.7 wherein the Crystalline Form A has a         single crystal structure represented by the ORTEP drawing of         FIG. 18.     -   1.9 Any of formulae 1.1-1.8 wherein the Crystalline Form A has a         calculated XRPD pattern as show in FIG. 23.     -   1.10 Any of formulae 1.1-1.9 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, 2-theta (°) values selected from the group         consisting of 15.4, 16.6, 17.2, 18.5, 19.5, 20.5, 20.7, 22.9,         and 25.7, wherein the XRPD is measured using an incident beam of         Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.11 Any of formulae 1.1-1.10 wherein the Crystalline Form A         exhibits an XRPD pattern comprising 2-theta (°) values of 15.4,         16.6, 17.2, 18.5, 19.5, 20.5, 20.7, 22.9, and 25.7, wherein the         XRPD is measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.12 Any of formulae 1.1-1.11 wherein the Crystalline Form A         exhibits an XRPD pattern having characteristic 2-theta (°)         values of 15.4, 16.6, 17.2, 18.5, 19.5, 20.5, 20.7, 22.9, and         25.7, wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.13 Any of formulae 1.1-1.12 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, 2-theta (°) values selected from the group         consisting 15.42, 16.55, 17.15, 18.50, 19.45, 20.46, 20.68,         22.90, and 25.69, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.14 Any of formulae 1.1-1.13 wherein the Crystalline Form A         exhibits an XRPD pattern comprising 2-theta (°) values of 15.42,         16.55, 17.15, 18.50, 19.45, 20.46, 20.68, 22.90, and 25.69,         wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation.     -   1.15 Any of formulae 1.1-1.14 wherein the Crystalline Form A         exhibits an XRPD pattern having characteristic 2-theta (°)         values of 15.42, 16.55, 17.15, 18.50, 19.45, 20.46, 20.68,         22.90, and 25.69, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.16 Any of formulae 1.1-1.15 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, 2-theta (°) values selected from those set forth in         Table A below:

TABLE A °2θ d space (Å) Intensity (%) 15.42 ± 0.20 5.741 ± 0.074 26 16.55 ± 0.20 5.352 ± 0.064 40 17.15 ± 0.20 5.167 ± 0.060 29 18.50 ± 0.20 4.792 ± 0.051 100 19.45 ± 0.20 4.560 ± 0.046 38 20.46 ± 0.20 4.338 ± 0.042 43 20.68 ± 0.20 4.291 ± 0.041 80 22.90 ± 0.20 3.880 ± 0.033 22 25.69 ± 0.20 3.466 ± 0.027 70

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.17 Any of formulae 1.1-1.16 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table A of formula 1.16, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.18 Any of formulae 1.1-1.17 wherein the Crystalline Form A         exhibits an XRPD pattern having characteristic 2-theta (°)         values as set forth in Table A of formula 1.16, wherein the XRPD         is measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.19 Any of formulae 1.1-1.18 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g. at least ten, 2-theta (°) values selected from         the group consisting of 12.3, 13.8, 15.4, 16.6, 17.2, 18.2,         18.5, 19.5, 20.5, 20.7, 22.9, and 25.7, wherein the XRPD is         measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.20 Any of formulae 1.1-1.19 wherein the Crystalline Form A         exhibits an XRPD pattern comprising 2-theta (°) values of 12.3,         13.8, 15.4, 16.6, 17.2, 18.2, 18.5, 19.5, 20.5, 20.7, 22.9, and         25.7, wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.21 Any of formulae 1.1-1.20 wherein the Crystalline Form A         exhibits an XRPD pattern having representative 2-theta (°)         values of 12.3, 13.8, 15.4, 16.6, 17.2, 18.2, 18.5, 19.5, 20.5,         20.7, 22.9, and 25.7, wherein the XRPD is measured using an         incident beam of Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.22 Any of formulae 1.1-1.21 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g. at least ten, 2-theta (°) values selected from         the group consisting of 12.26, 13.78, 15.42, 16.55, 17.15,         18.19, 18.50, 19.45, 20.46, 20.68, 22.90, and 25.69, wherein the         XRPD is measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.23 Any of formulae 1.1-1.22 wherein the Crystalline Form A         exhibits an XRPD pattern comprising 2-theta (°) values of 12.26,         13.78, 15.42, 16.55, 17.15, 18.19, 18.50, 19.45, 20.46, 20.68,         22.90, and 25.69, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.24 Any of formulae 1.1-1.23 wherein the Crystalline Form A         exhibits an XRPD pattern having representative 2-theta (°)         values of 12.26, 13.78, 15.42, 16.55, 17.15, 18.19, 18.50,         19.45, 20.46, 20.68, 22.90, and 25.69, wherein the XRPD is         measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.25 Any of formulae 1.1-1.24 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least ten, 2-theta (°) values selected from         those set forth in Table B below:

TABLE B °2θ d space (Å) Intensity (%) 12.26 ± 0.20 7.211 ± 0.117 22 13.78 ± 0.20 6.421 ± 0.093 36 15.42 ± 0.20 5.741 ± 0.074 26 16.55 ± 0.20 5.352 ± 0.064 40 17.15 ± 0.20 5.167 ± 0.060 29 18.19 ± 0.20 4.873 ± 0.053 100 18.50 ± 0.20 4.792 ± 0.051 100 19.45 ± 0.20 4.560 ± 0.046 38 20.46 ± 0.20 4.338 ± 0.042 43 20.68 ± 0.20 4.291 ± 0.041 80 22.90 ± 0.20 3.880 ± 0.033 22 25.69 ± 0.20 3.466 ± 0.027 70

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.26 Any of formulae 1.1-1.25 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table B of formula 1.25, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.27 Any of formulae 1.1-1.26 wherein the Crystalline Form A         exhibits an XRPD pattern having representative 2-theta (°)         values as set forth in Table B of formula 1.25, wherein the XRPD         is measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.28 Any of formulae 1.1-1.27 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least twelve, e.g., at least fifteen, e.g., at least twenty,         2-theta (°) values selected from the group consisting of 6.9,         12.3, 13.8, 14.5, 15.4, 16.6, 17.2, 18.2, 18.5, 19.5, 20.1,         20.5, 20.7, 21.0, 21.5, 22.9, 24.7, 25.2, 25.4, 25.7, 26.4,         27.5, and 27.8, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.29 Any of formulae 1.1-1.28 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the following 2-theta (°)         values:     -    6.9, 12.3, 13.8, 14.5, 15.4, 16.6, 17.2, 18.2, 18.5, 19.5,         20.1, 20.5, 20.7, 21.0, 21.5, 22.9, 24.7, 25.2, 25.4, 25.7,         26.4, 27.5, and 27.8,     -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.30 Any of formulae 1.1-1.29 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least twelve, e.g., at least fifteen, e.g., at least twenty,         2-theta (°) values selected from the group consisting of 6.87,         12.26, 13.78, 14.49, 15.42, 16.55, 17.15, 18.19, 18.50, 19.45,         20.06, 20.46, 20.68, 20.96, 21.54, 22.90, 24.69, 25.17, 25.44,         25.69, 26.36, 27.52, and 27.76, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.31 Any of formulae 1.1-1.30 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the following 2-theta (°)         values:     -    6.87, 12.26, 13.78, 14.49, 15.42, 16.55, 17.15, 18.19, 18.50,         19.45, 20.06, 20.46, 20.68, 20.96, 21.54, 22.90, 24.69, 25.17,         25.44, 25.69, 26.36, 27.52, and 27.76,     -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.32 Any of formulae 1.1-1.31 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least twelve, e.g., at least fifteen, e.g., at least twenty,         2-theta (°) values selected from those set forth in Table C         below:

TABLE C °2θ d space (Å) Intensity (%)  6.87 ± 0.20 12.859 ± 0.374  6 12.26 ± 0.20 7.211 ± 0.117 22 13.78 ± 0.20 6.421 ± 0.093 36 14.49 ± 0.20 6.106 ± 0.084 6 15.42 ± 0.20 5.741 ± 0.074 26 16.55 ± 0.20 5.352 ± 0.064 40 17.15 ± 0.20 5.167 ± 0.060 29 18.19 ± 0.20 4.873 ± 0.053 100 18.50 ± 0.20 4.792 ± 0.051 100 19.45 ± 0.20 4.560 ± 0.046 38 20.06 ± 0.20 4.422 ± 0.044 9 20.46 ± 0.20 4.338 ± 0.042 43 20.68 ± 0.20 4.291 ± 0.041 80 20.96 ± 0.20 4.236 ± 0.040 11 21.54 ± 0.20 4.123 ± 0.038 10 22.90 ± 0.20 3.880 ± 0.033 22 24.69 ± 0.20 3.602 ± 0.029 3 25.17 ± 0.20 3.535 ± 0.028 14 25.44 ± 0.20 3.499 ± 0.027 13 25.69 ± 0.20 3.466 ± 0.027 70 26.36 ± 0.20 3.378 ± 0.025 13 27.52 ± 0.20 3.239 ± 0.023 23 27.76 ± 0.20 3.211 ± 0.023 7

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.33 Any of formulae 1.1-1.32 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table C of formula 1.32, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.34 Any of formulae 1.1-1.33 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from the group         consisting of 5.7, 5.4, 5.2, 4.8, 4.6, 4.3, 3.9, and 3.5.     -   1.35 Any of formulae 1.1-1.34 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of 5.7,         5.4, 5.2, 4.8, 4.6, 4.3, 3.9, and 3.5.     -   1.36 Any of formulae 1.1-1.35 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from the group         consisting of 5.74, 5.35, 5.17, 4.79, 4.56, 4.34, 4.29, 3.88,         and 3.47.     -   1.37 Any of formulae 1.1-1.36 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of         5.74, 5.35, 5.17, 4.79, 4.56, 4.34, 4.29, 3.88, and 3.47.     -   1.38 Any of formulae 1.1-1.37 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from the group         consisting of 5.741, 5.352, 5.167, 4.792, 4.560, 4.338, 4.291,         3.880, and 3.466.     -   1.39 Any of formulae 1.1-1.38 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of         5.741, 5.352, 5.167, 4.792, 4.560, 4.338, 4.291, 3.880, and         3.466.     -   1.40 Any of formulae 1.1-1.39 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from those set forth         in Table A of formula 1.16.     -   1.41 Any of formulae 1.1-1.40 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the d-spacing (Å) values set         forth in Table A of formula 1.16.     -   1.42 Any of formulae 1.1-1.41 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least ten, d-spacing (Å) values selected         from the group consisting of 7.2, 6.4, 5.7, 5.4, 5.2, 4.9, 4.8,         4.6, 4.3, 3.9, and 3.5.     -   1.43 Any of formulae 1.1-1.42 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of 7.2,         6.4, 5.7, 5.4, 5.2, 4.9, 4.8, 4.6, 4.3, 3.9, and 3.5.     -   1.44 Any of formulae 1.1-1.43 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least ten, d-spacing (Å) values selected         from the group consisting of 7.21, 6.42, 5.74, 5.35, 5.17, 4.87,         4.79, 4.56, 4.34, 4.29, 3.88, and 3.47.     -   1.45 Any of formulae 1.1-1.44 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of         7.21, 6.42, 5.74, 5.35, 5.17, 4.87, 4.79, 4.56, 4.34, 4.29,         3.88, and 3.47.     -   1.46 Any of formulae 1.1-1.45 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least ten, d-spacing (Å) values selected         from the group consisting of 7.211, 6.421, 5.741, 5.352, 5.167,         4.873, 4.792, 4.560, 4.338, 4.291, 3.880, and 3.466.     -   1.47 Any of formulae 1.1-1.46 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of         7.211, 6.421, 5.741, 5.352, 5.167, 4.873, 4.792, 4.560, 4.338,         4.291, 3.880, and 3.466.     -   1.48 Any of formulae 1.1-1.47 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least ten, d-spacing (Å) values selected         from those set forth in Table B of formula 1.25.     -   1.49 Any of formulae 1.1-1.48 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the d-spacing (Å) values set         forth in Table B of formula 1.25.     -   1.50 Any of formulae 1.1-1.49 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least twelve, e.g., at least fifteen, d-spacing (Å) values         selected from the group consisting of 12.9, 7.2, 6.4, 6.1, 5.7,         5.4, 5.2, 4.9, 4.8, 4.6, 4.4, 4.3, 4.2, 4.1, 3.9, 3.6, 3.5, 3.4,         and 3.2.     -   1.51 Any of formulae 1.1-1.50 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.9, 7.2, 6.4, 6.1, 5.7, 5.4, 5.2, 4.9, 4.8, 4.6, 4.4, 4.3,         4.2, 4.1, 3.9, 3.6, 3.5, 3.4, and 3.2.     -   1.52 Any of formulae 1.1-1.51 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least twelve, e.g., at least fifteen, e.g., at least twenty,         d-spacing (Å) values selected from the group consisting of         12.86, 7.21, 6.42, 6.11, 5.74, 5.35, 5.17, 4.87, 4.79, 4.56,         4.42, 4.34, 4.29, 4.24, 4.12, 3.88, 3.60, 3.54, 3.50, 3.47,         3.38, 3.24, and 3.21.     -   1.53 Any of formulae 1.1-1.52 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.86, 7.21, 6.42, 6.11, 5.74, 5.35, 5.17, 4.87, 4.79, 4.56,         4.42, 4.34, 4.29, 4.24, 4.12, 3.88, 3.60, 3.54, 3.50, 3.47,         3.38, 3.24, and 3.21.     -   1.54 Any of formulae 1.1-1.53 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least twelve, e.g., at least fifteen, e.g., at least twenty,         d-spacing (Å) values selected from the group consisting of         12.859, 7.211, 6.421, 6.106, 5.741, 5.352, 5.167, 4.873, 4.792,         4.560, 4.422, 4.338, 4.291, 4.236, 4.123, 3.880, 3.602, 3.535,         3.499, 3.466, 3.378, 3.239, and 3.211.     -   1.55 Any of formulae 1.1-1.54 wherein the Crystalline Form A         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.859, 7.211, 6.421, 6.106, 5.741, 5.352, 5.167, 4.873, 4.792,         4.560, 4.422, 4.338, 4.291, 4.236, 4.123, 3.880, 3.602, 3.535,         3.499, 3.466, 3.378, 3.239, and 3.211.     -   1.56 Any of formulae 1.1-1.55 wherein the Crystalline Form A         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least twelve, e.g., at least fifteen, e.g., at least twenty,         d-spacing (Å) values selected from those set forth in Table C of         formula 1.32.     -   1.57 Any of formulae 1.1-1.56 wherein the Crystalline Form A         exhibits an XRPD pattern comprising the d-spacing (Å) values set         forth in Table C of formula 1.32.     -   1.58 Any of formulae 1.1-1.57 wherein the Crystalline Form A         exhibits an XRPD pattern comprising characteristic peaks of the         XRPD pattern shown in FIG. 1, wherein the XRPD is measured using         Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.59 Any of formulae 1.1-1.58 wherein the Crystalline Form A         exhibits an XRPD pattern comprising representative peaks of the         XRPD pattern shown in FIG. 1, wherein the XRPD is measured using         Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.60 Any of formulae 1.1-1.59 wherein the Crystalline Form A         exhibits an X-ray powder diffraction (XRPD) pattern, e.g., an         X-ray powder diffraction pattern measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., a high-resolution         X-ray powder diffraction pattern measured using an incident beam         of Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å, comprising three peaks, in         some embodiments, five peaks, selected from those shown in FIG.         1.     -   1.61 Any of formulae 1.1-1.60 wherein the Crystalline Form A         exhibits an XRPD pattern, e.g., an XRPD pattern measured using         an incident beam of Cu radiation, e.g., Cu Kα radiation, e.g., a         high-resolution XRPD pattern measured using an incident beam of         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å, comprising at least nine         peaks, e.g., at least ten peaks, e.g., at least twelve peaks,         e.g., at least fifteen peaks, e.g., at least twenty peaks,         selected from those shown in FIG. 1.     -   1.62 Any of formulae 1.1-1.61 wherein the Crystalline Form A         exhibits an X-ray powder diffraction (XRPD) pattern, e.g., an         X-ray powder diffraction pattern measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD         is measured using radiation of wavelength 1.54059 Å,         substantially as shown in FIG. 1.     -   1.63 Any of formulae 1.1-1.62 wherein the Crystalline Form A         exhibits an X-ray powder diffraction (XRPD) pattern, e.g., an         X-ray powder diffraction pattern measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD         is measured using radiation of wavelength 1.54059 Å, as shown in         FIG. 1.     -   1.64 Any of formulae 1.1-1.63 wherein the Crystalline Form A         exhibits an XRPD pattern comprising characteristic peaks of the         XRPD pattern shown in any of FIGS. 1, 35, 37, and 47, e.g., FIG.         1, e.g., FIG. 35, e.g., FIG. 37, e.g., FIG. 47, wherein the XRPD         is measured using Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.65 Any of formulae 1.1-1.64 wherein the Crystalline Form A         exhibits an XRPD pattern comprising representative peaks of the         XRPD pattern shown in any of FIGS. 1, 35, 37, and 47, e.g., FIG.         1, e.g., FIG. 35, e.g., FIG. 37, e.g., FIG. 47, wherein the XRPD         is measured using Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.66 Any of formulae 1.1-1.65 wherein the Crystalline Form A         exhibits an XRPD pattern, e.g., an XRPD pattern measured using         an incident beam of Cu radiation, e.g., Cu Kα radiation, e.g., a         high-resolution XRPD pattern measured using an incident beam of         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å, comprising three peaks, in         some embodiments, five peaks, selected from those shown in any         of FIGS. 1, 35, 37, and 47, e.g., FIG. 1, e.g., FIG. 35, e.g.,         FIG. 37, e.g., FIG. 47.     -   1.67 Any of formulae 1.1-1.66 wherein the Crystalline Form A         exhibits an XRPD pattern, e.g., an XRPD pattern measured using         an incident beam of Cu radiation, e.g., Cu Kα radiation, e.g., a         high-resolution XRPD pattern measured using an incident beam of         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å, comprising at least nine         peaks, e.g., at least ten peaks, e.g., at least twelve peaks,         e.g., at least fifteen peaks, e.g., at least twenty peaks,         selected from those shown in any of FIGS. 1, 35, 37, and 47,         e.g., FIG. 1, e.g., FIG. 35, e.g., FIG. 37, e.g., FIG. 47.     -   1.68 Any of formulae 1.1-1.67 wherein the Crystalline Form A         exhibits an XRPD pattern, e.g., an XRPD pattern measured using         an incident beam of Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å, substantially as shown in any of FIGS. 1, 35, 37, and         47, e.g., FIG. 1, e.g., FIG. 35, e.g., FIG. 37, e.g., FIG. 47.     -   1.69 Any of formulae 1.1-1.68 wherein the Crystalline Form A         exhibits an XRPD pattern, e.g., an XRPD pattern measured using         an incident beam of Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å, as shown in any of FIGS. 1, 35, 37, and 47, e.g.,         FIG. 1, e.g., FIG. 35, e.g., FIG. 37, e.g., FIG. 47.     -   1.70 Any of formulae 1.1-1.69 wherein the Crystalline Form A         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak between 245° C. and 249° C.,         e.g., between 245° C. and 248° C., e.g., wherein the Crystalline         Form A exhibits a differential scanning calorimetry (DSC)         thermogram comprising multiple, e.g., three, endotherms between         245° C. and 249° C., e.g., between 245° C. and 248° C., e.g.,         wherein the Crystalline Form A exhibits a differential scanning         calorimetry (DSC) thermogram comprising an endothermic peak at         247° C. with an onset at 245° C., an endothermic shoulder at         248° C., and an endothermic peak at 248° C.     -   1.71 Any of formulae 1.1-1.70 wherein the Crystalline Form A         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 247° C., e.g., an endothermic         peak at 247° C. with an onset at 245° C.     -   1.72 Any of formulae 1.1-1.71 wherein the Crystalline Form A         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 248° C.     -   1.73 Any of formulae 1.1-1.72 wherein the Crystalline Form A         exhibits a differential scanning calorimetry (DSC) thermogram as         shown in FIG. 2.     -   1.74 Any of formulae 1.1-1.73 wherein the Crystalline Form A         exhibits a thermogravimetric analysis (TGA) thermogram         comprising 0.4% weight loss up to 200° C.     -   1.75 Any of formulae 1.1-1.74 having a thermogravimetric         analysis (TGA) thermogram comprising an onset decomposition         temperature at 276° C.     -   1.76 Any of formulae 1.1-1.75 wherein the Crystalline Form A         exhibits a thermogravimetric analysis (TGA) thermogram as shown         in FIG. 2.     -   1.77 Any of formulae 1.1-1.76 wherein the Crystalline Form A         exhibits a dynamic vapor sorption/desporption isotherm as shown         in FIG. 3, e.g., a dynamic vapor sorption/desporption isotherm         wherein Crystalline Form A shows:     -    a weight loss of 0.03% upon equilibration at 5% RH;     -    a weight gain of 0.10% from 5% to 95% RH; and     -    a 0.10% weight loss from 95% to 5% RH.     -   1.78 Crystalline Form B of the Compound in hydrochloric acid         addition salt form         ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride) (“Crystalline Form B”).     -   1.79 Formula 1.78 wherein the Crystalline Form B belongs to the         P2₁2₁2₁ space group and has the following unit cell parameters:     -    a=5.9055(2) Å, b=7.4645(3) A, c=29.1139(13) A, α=β=γ=90°.     -   1.80 Formula 1.78 wherein the Crystalline Form B belongs to the         P2₁2₁2₁ space group and has any combination of the following         unit cell parameters:     -    a=5-7 Å, e.g., 6 Å, e.g., 5.7-6.1 Å, e.g., 5.8-6.0 Å, e.g., 5.9         Å, e.g., 5.91, e.g., 5.906 Å;     -    b=6-8 Å, e.g., 7 Å, e.g., 7.3-7.7 Å, e.g., 7.4-7.6 Å, e.g., 7.5         Å, e.g., 7.46 Å, e.g., 7.465 Å;     -    c=28-30 Å, e.g., 29 Å, e.g., 28.9-29.3 Å, e.g., 29.0-29.2 Å,         e.g., 29.1 Å, e.g., 29.11 Å, e.g., 29.114 Å; and     -    α=β=γ=90°.     -   1.81 Any of formulae 1.78-1.80 wherein the Crystalline Form B         has a calculated volume of V=1283.39(9) Å³.     -   1.82 Any of formulae 1.78-1.81 wherein the crystal structure of         the Crystalline Form B is obtained with a crystal having         approximate dimensions of 0.31 mm×0.21 mm×0.09 mm, e.g., a         colorless plate having approximate dimensions of 0.31 mm×0.21         mm×0.09 mm.     -   1.83 Any of formulae 1.78-1.82 wherein the crystal structure of         the Crystalline Form B is obtained with Cu Kα radiation, e.g.,         Cu Kα having λ=1.54178 Å.     -   1.84 Any of formulae 1.78-1.83 wherein the crystal structure of         the Crystalline Form B is obtained at 100(2) K.     -   1.85 Any of formulae 1.78-1.84 wherein the Crystalline Form B         has a single crystal structure represented by the atomic         displacement ellipsoid drawing of FIG. 24.     -   1.86 Any of formulae 1.78-1.85 wherein the Crystalline Form B         has a calculated XRPD pattern as shown in FIG. 32.     -   1.87 Any of formulae 1.78-1.86 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three 2-theta (°)         values selected from the group consisting of 6.0, 17.4, 18.9,         19.2, and 24.4, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.88 Any of formulae 1.78-1.87 wherein the Crystalline Form B         exhibits an XRPD pattern comprising 2-theta (°) values of 6.0,         17.4, 18.9, 19.2, and 24.4, wherein the XRPD is measured using         an incident beam of Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.89 Any of formulae 1.78-1.88 wherein the Crystalline Form B         exhibits an XRPD pattern having characteristic 2-theta (°)         values of 6.0, 17.4, 18.9, 19.2, and 24.4, wherein the XRPD is         measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.90 Any of formulae 1.78-1.89 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three 2-theta (°)         values selected from the group consisting of 6.04, 17.41, 18.94,         19.19, and 24.39, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.91 Any of formulae 1.78-1.90 wherein the Crystalline Form B         exhibits an XRPD pattern comprising 2-theta (°) values of 6.04,         17.41, 18.94, 19.19, and 24.39, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.92 Any of formulae 1.78-1.91 wherein the Crystalline Form B         exhibits an XRPD pattern having characteristic 2-theta (°)         values of 6.04, 17.41, 18.94, 19.19, and 24.39, wherein the XRPD         is measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.93 Any of formulae 1.78-1.92 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three 2-theta (°)         values selected from those set forth in Table D below:

TABLE D °2θ d space (Å) Intensity (%)  6.04 ± 0.20 14.620 ± 0.484  13 17.41 ± 0.20 5.089 ± 0.058 14 18.94 ± 0.20 4.681 ± 0.049 79 19.19 ± 0.20 4.622 ± 0.048 100 24.39 ± 0.20 3.646 ± 0.029 23

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.94 Any of formulae 1.78-1.93 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table D of formula 1.93, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.95 Any of formulae 1.78-1.94 wherein the Crystalline Form B         exhibits an XRPD pattern having characteristic 2-theta (°)         values as set forth in Table D of formula 1.93, wherein the XRPD         is measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.96 Any of formulae 1.78-1.95 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, 2-theta (°) values selected from the group         consisting of 6.0, 13.2, 17.4, 18.9, 19.2, 23.6, 23.8, 24.4, and         28.2, wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.97 Any of formulae 1.78-1.96 wherein the Crystalline Form B         exhibits an XRPD pattern comprising 2-theta (°) values of 6.0,         13.2, 17.4, 18.9, 19.2, 23.6, 23.8, 24.4, and 28.2, wherein the         XRPD is measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.98 Any of formulae 1.78-1.97 wherein the Crystalline Form B         exhibits an XRPD pattern having representative 2-theta (°)         values of 6.0, 13.2, 17.4, 18.9, 19.2, 23.6, 23.8, 24.4, and         28.2, wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.99 Any of formulae 1.78-1.98 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, 2-theta (°) values selected from the group         consisting of 6.04, 13.21, 17.41, 18.94, 19.19, 23.59, 23.79,         24.39, and 28.15, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.100 Any of formulae 1.78-1.99 wherein the Crystalline Form B         exhibits an XRPD pattern comprising 2-theta (°) values of 6.04,         13.21, 17.41, 18.94, 19.19, 23.59, 23.79, 24.39, and 28.15,         wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.101 Any of formulae 1.78-1.100 wherein the Crystalline Form B         exhibits an XRPD pattern having representative 2-theta (°)         values of 6.04, 13.21, 17.41, 18.94, 19.19, 23.59, 23.79, 24.39,         and 28.15, wherein the XRPD is measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD         is measured using radiation of wavelength 1.54059 Å.     -   1.102 Any of formulae 1.78-1.101 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, 2-theta (°) values selected from those set forth in         Table E below:

TABLE E °2θ d space (Å) Intensity (%)  6.04 ± 0.20 14.620 ± 0.484  13 13.21 ± 0.20 6.699 ± 0.101 21 17.41 ± 0.20 5.089 ± 0.058 14 18.94 ± 0.20 4.681 ± 0.049 79 19.19 ± 0.20 4.622 ± 0.048 100 23.59 ± 0.20 3.769 ± 0.032 16 23.79 ± 0.20 3.737 ± 0.031 43 24.39 ± 0.20 3.646 ± 0.029 23 28.15 ± 0.20 3.168 ± 0.022 24

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.103 Any of formulae 1.78-1.102 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table E of formula 1.102, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.104 Any of formulae 1.78-1.103 wherein the Crystalline Form B         exhibits an XRPD pattern having representative 2-theta (°)         values as set forth in Table E of formula 1.102, wherein the         XRPD is measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.105 Any of formulae 1.78-1.104 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least fifteen, e.g., at least twenty, e.g., at least         twenty-five, 2-theta (°) values selected from the group         consisting of 6.0, 12.1, 13.2, 14.9, 15.1, 16.0, 16.9, 17.4,         18.2, 18.9, 19.2, 19.9, 21.1, 21.3, 21.7, 22.6, 23.6, 23.8,         24.4, 25.3, 26.1, 26.6, 27.2, 28.2, 28.7, and 29.5, wherein the         XRPD is measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.106 Any of formulae 1.78-1.105 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the following 2-theta (°)         values: 6.0, 12.1, 13.2, 14.9, 15.1, 16.0, 16.9, 17.4, 18.2,         18.9, 19.2, 19.9, 21.1, 21.3, 21.7, 22.6, 23.6, 23.8, 24.4,         25.3, 26.1, 26.6, 27.2, 28.2, 28.7, and 29.5, wherein the XRPD         is measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.107 Any of formulae 1.78-1.106 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least fifteen, e.g., at least twenty, e.g., at least         twenty-five, 2-theta (°) values selected from the group         consisting of 6.04, 12.12, 13.21, 14.86, 15.13, 16.02, 16.90,         17.41, 18.23, 18.94, 19.19, 19.91, 21.05, 21.27, 21.74, 22.55,         23.59, 23.79, 24.39, 25.34, 26.06, 26.61, 27.15, 28.15, 28.66,         and 29.47, wherein the XRPD is measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD         is measured using radiation of wavelength 1.54059 Å.     -   1.108 Any of formulae 1.78-1.107 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the following 2-theta (°)         values:     -    6.04, 12.12, 13.21, 14.86, 15.13, 16.02, 16.90, 17.41, 18.23,         18.94, 19.19, 19.91, 21.05, 21.27, 21.74, 22.55, 23.59, 23.79,         24.39, 25.34, 26.06, 26.61, 27.15, 28.15, 28.66, and 29.47,     -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.109 Any of formulae 1.78-1.108 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least fifteen, e.g., at least twenty, e.g., at least         twenty-five, e.g., at least five, 2-theta (°) values selected         from those set forth in Table F below:

TABLE F °2θ d space (Å) Intensity (%)  6.04 ± 0.20 14.620 ± 0.484  13 12.12 ± 0.20 7.296 ± 0.120 6 13.21 ± 0.20 6.699 ± 0.101 21 14.86 ± 0.20 5.958 ± 0.080 8 15.13 ± 0.20 5.853 ± 0.077 5 16.02 ± 0.20 5.529 ± 0.069 1 16.90 ± 0.20 5.242 ± 0.062 4 17.41 ± 0.20 5.089 ± 0.058 14 18.23 ± 0.20 4.861 ± 0.053 10 18.94 ± 0.20 4.681 ± 0.049 79 19.19 ± 0.20 4.622 ± 0.048 100 19.91 ± 0.20 4.457 ± 0.044 4 21.05 ± 0.20 4.217 ± 0.040 11 21.27 ± 0.20 4.173 ± 0.039 2 21.74 ± 0.20 4.085 ± 0.037 4 22.55 ± 0.20 3.939 ± 0.034 6 23.59 ± 0.20 3.769 ± 0.032 16 23.79 ± 0.20 3.737 ± 0.031 43 24.39 ± 0.20 3.646 ± 0.029 23 25.34 ± 0.20 3.512 ± 0.027 1 26.06 ± 0.20 3.416 ± 0.026 2 26.61 ± 0.20 3.347 ± 0.025 1 27.15 ± 0.20 3.282 ± 0.024 2 28.15 ± 0.20 3.168 ± 0.022 24 28.66 ± 0.20 3.112 ± 0.021 13 29.47 ± 0.20 3.028 ± 0.020 13

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.110 Any of formulae 1.78-1.109 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table F of formula 1.109, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.111 Any of formulae 1.78-1.110 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three d-spacing (Å)         values selected from the group consisting of 14.6, 5.1, 4.7,         4.6, and 3.6.     -   1.112 Any of formulae 1.78-1.111 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.6, 5.1, 4.7, 4.6, and 3.6.     -   1.113 Any of formulae 1.78-1.112 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three d-spacing (Å)         values selected from the group consisting of 14.62, 5.09, 4.68,         4.62, and 3.65.     -   1.114 Any of formulae 1.78-1.113 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.62, 5.09, 4.68, 4.62, and 3.65.     -   1.115 Any of formulae 1.78-1.114 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three d-spacing (Å)         values selected from the group consisting of 14.620, 5.089,         4.681, 4.622, and 3.646.     -   1.116 Any of formulae 1.78-1.115 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.620, 5.089, 4.681, 4.622, and 3.646.     -   1.117 Any of formulae 1.78-1.116 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three d-spacing (Å)         values selected from those set forth in Table D of formula 1.93.     -   1.118 Any of formulae 1.78-1.117 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the d-spacing (Å) values set         forth in Table D of formula 1.93.     -   1.119 Any of formulae 1.78-1.118 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from the group         consisting of 14.6, 6.7, 5.1, 4.7, 4.6, 3.8, 3.7, 3.6, and 3.2.     -   1.120 Any of formulae 1.78-1.119 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.6, 6.7, 5.1, 4.7, 4.6, 3.8, 3.7, 3.6, and 3.2.     -   1.121 Any of formulae 1.78-1.120 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from the group         consisting of 14.62, 6.70, 5.09, 4.68, 4.62, 3.77, 3.74, 3.65,         and 3.17.     -   1.122 Any of formulae 1.78-1.121 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.62, 6.70, 5.09, 4.68, 4.62, 3.77, 3.74, 3.65, and 3.17.     -   1.123 Any of formulae 1.78-1.122 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from the group         consisting of 14.620, 6.699, 5.089, 4.681, 4.622, 3.769, 3.737,         3.646, and 3.168.     -   1.124 Any of formulae 1.78-1.123 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.620, 6.699, 5.089, 4.681, 4.622, 3.769, 3.737, 3.646, and         3.168.     -   1.125 Any of formulae 1.78-1.124 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, d-spacing (Å) values selected from those set forth         in Table E of formula 1.102.     -   1.126 Any of formulae 1.78-1.125 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the d-spacing (Å) values set         forth in Table E of formula 1.102.     -   1.127 Any of formulae 1.78-1.126 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least fifteen, e.g., at least twenty, d-spacing (Å) values         selected from the group consisting of 14.6, 7.3, 6.7, 6.0, 5.9,         5.5, 5.2, 5.1, 4.9, 4.7, 4.6, 4.5, 4.2, 4.1, 3.9, 3.8, 3.7, 3.6,         3.5, 3.4, 3.3, 3.2, 3.1, and 3.0.     -   1.128 Any of formulae 1.78-1.127 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.6, 7.3, 6.7, 6.0, 5.9, 5.5, 5.2, 5.1, 4.9, 4.7, 4.6, 4.5,         4.2, 4.1, 3.9, 3.8, 3.7, 3.6, 3.5, 3.4, 3.3, 3.2, 3.1, and 3.0.     -   1.129 Any of formulae 1.78-1.128 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least fifteen, e.g., at least twenty, e.g., at least         twenty-five, d-spacing (Å) values selected from the group         consisting of 14.62, 7.30, 6.70, 5.96, 5.85, 5.53, 5.24, 5.09,         4.86, 4.68, 4.62, 4.46, 4.22, 4.17, 4.09, 3.94, 3.77, 3.74,         3.65, 3.51, 3.42, 3.35, 3.28, 3.17, 3.11, and 3.03.     -   1.130 Any of formulae 1.78-1.129 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.62, 7.30, 6.70, 5.96, 5.85, 5.53, 5.24, 5.09, 4.86, 4.68,         4.62, 4.46, 4.22, 4.17, 4.09, 3.94, 3.77, 3.74, 3.65, 3.51,         3.42, 3.35, 3.28, 3.17, 3.11, and 3.03.     -   1.131 Any of formulae 1.78-1.130 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least fifteen, e.g., at least twenty, e.g., at least         twenty-five, d-spacing (Å) values selected from the group         consisting of 14.620, 7.296, 6.699, 5.958, 5.853, 5.529, 5.242,         5.089, 4.861, 4.681, 4.622, 4.457, 4.217, 4.173, 4.085, 3.939,         3.769, 3.737, 3.646, 3.512, 3.416, 3.347, 3.282, 3.168, 3.112,         and 3.028.     -   1.132 Any of formulae 1.78-1.131 wherein the Crystalline Form B         exhibits an XRPD pattern comprising d-spacing (Å) values of         14.620, 7.296, 6.699, 5.958, 5.853, 5.529, 5.242, 5.089, 4.861,         4.681, 4.622, 4.457, 4.217, 4.173, 4.085, 3.939, 3.769, 3.737,         3.646, 3.512, 3.416, 3.347, 3.282, 3.168, 3.112, and 3.028.     -   1.133 Any of formulae 1.78-1.132 wherein the Crystalline Form B         exhibits an XRPD pattern comprising at least three, e.g., at         least five, e.g., at least nine, e.g., at least ten, e.g., at         least fifteen, e.g., at least twenty, e.g., at least         twenty-five, d-spacing (Å) values selected from those set forth         in Table F of formula 1.109.     -   1.134 Any of formulae 1.78-1.133 wherein the Crystalline Form B         exhibits an XRPD pattern comprising the d-spacing (Å) values set         forth in Table F of formula 1.109.     -   1.135 Any of formulae 1.78-1.134 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern comprising         characteristic peaks of the XRPD pattern shown in FIG. 5,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.541871 Å.     -   1.136 Any of formulae 1.78-1.135 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern comprising         representative peaks of the XRPD pattern shown in FIG. 5,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.541871 Å.     -   1.137 Any of formulae 1.78-1.136 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         three peaks, in some embodiments, five peaks, selected from         those shown in FIG. 5.     -   1.138 Any of formulae 1.78-1.137 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising at         least five peaks, e.g., at least nine peaks, e.g., at least ten         peaks, e.g., at least fifteen peaks, e.g., at least twenty         peaks, e.g., at least twenty-five peaks, selected from those         shown in FIG. 5.     -   1.139 Any of formulae 1.78-1.138 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, substantially         as shown in FIG. 5.     -   1.140 Any of formulae 1.78-1.139 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, as shown in         FIG. 5.     -   1.141 Any of formulae 1.78-1.140 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern comprising         characteristic peaks of the XRPD pattern shown in FIG. 7,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, e.g., wherein XRPD pattern also comprises         peaks of Crystalline Form A (e.g., a mixture of Crystalline         Forms A and B).     -   1.142 Any of formulae 1.78-1.141 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern comprising         representative peaks of the XRPD pattern shown in FIG. 7,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, e.g., wherein XRPD pattern also comprises         peaks of Crystalline Form A (e.g., a mixture of Crystalline         Forms A and B).     -   1.143 Any of formulae 1.78-1.142 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, comprising three peaks, in some         embodiments, five peaks, selected from those shown in FIG. 7,         e.g., wherein XRPD pattern also comprises peaks of Crystalline         Form A (e.g., a mixture of Crystalline Forms A and B).     -   1.144 Any of formulae 1.78-1.143 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, comprising at least five peaks, e.g.,         at least nine peaks, e.g., at least ten peaks, e.g., at least         fifteen peaks, e.g., at least twenty peaks, e.g., at least         twenty-five peaks, selected from those shown in FIG. 7, e.g.,         wherein XRPD pattern comprises peaks of Crystalline Form A         (e.g., a mixture of Crystalline Forms A and B).     -   1.145 Any of formulae 1.78-1.144 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, substantially as shown in FIG. 7, e.g.,         wherein XRPD pattern comprises peaks of Crystalline Form A         (e.g., a mixture of Crystalline Forms A and B).     -   1.146 Any of formulae 1.78-1.145 wherein the Crystalline Form B         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, as shown in FIG. 7, e.g., wherein XRPD         pattern comprises peaks of Crystalline Form A (e.g., a mixture         of Crystalline Forms A and B).     -   1.147 Any of formulae 1.78-1.146 wherein the Crystalline Form B         exhibits an XRPD pattern comprising characteristic peaks of the         XRPD pattern shown in any of FIGS. 7, 40, and 48, e.g., FIG. 7,         e.g., FIG. 40, e.g., FIG. 48, wherein the XRPD is measured using         Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.148 Any of formulae 1.78-1.147 wherein the Crystalline Form B         exhibits an XRPD pattern comprising representative peaks of the         XRPD pattern shown in any of FIGS. 7, 40, and 48, e.g., FIG. 7,         e.g., FIG. 40, e.g., FIG. 48, wherein the XRPD is measured using         Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.149 Any of formulae 1.78-1.148 wherein the Crystalline Form B         exhibits an XRPD pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., a high-resolution X-ray powder         diffraction pattern measured using an incident beam of Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, comprising three peaks, in some         embodiments, five peaks, selected from those shown in any of         FIGS. 7, 40, and 48, e.g., FIG. 7, e.g., FIG. 40, e.g., FIG. 48.     -   1.150 Any of formulae 1.78-1.149 wherein the Crystalline Form B         exhibits an XRPD pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., a high-resolution X-ray powder         diffraction pattern measured using an incident beam of Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, comprising at least five, e.g., at least         nine, e.g., at least ten, e.g., at least fifteen, e.g., at least         twenty, e.g., at least twenty-five, selected from those shown in         any of FIGS. 7, 40, and 48, e.g., FIG. 7, e.g., FIG. 40, e.g.,         FIG. 48.     -   1.151 Any of formulae 1.78-1.150 wherein the Crystalline Form B         exhibits an XRPD pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å, substantially as shown in any         of FIGS. 7, 40, and 48, e.g., FIG. 7, e.g., FIG. 40, e.g., FIG.         48.     -   1.152 Any of formulae 1.1-1.151 wherein the Crystalline Form B         exhibits an X-ray powder diffraction (XRPD) pattern, e.g., an         X-ray powder diffraction pattern measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD         is measured using radiation of wavelength 1.54059 Å, as shown in         any of FIGS. 7, 40, and 48, e.g., FIG. 7, e.g., FIG. 40, e.g.,         FIG. 48.     -   1.153 Any of formulae 1.78-1.152 wherein the Crystalline Form B         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak between 247° C. and 248° C.     -   1.154 Any of formulae 1.78-1.153 wherein the Crystalline Form B         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 247° C.     -   1.155 Any of formulae 1.78-1.154 wherein the Crystalline Form B         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 248° C., e.g., an endothermic         peak at 248° C. with an onset at 246° C.     -   1.156 Any of formulae 1.78-1.155 wherein the Crystalline Form B         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 251° C.     -   1.157 Any of formulae 1.78-1.156 wherein the Crystalline Form B         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 264° C.     -   1.158 Any of formulae 1.78-1.157 wherein the Crystalline Form B         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 141° C., e.g., an endothermic         peak at 141° C. with an onset between 137° C. and 138° C., e.g.,         an endothermic peak at 141° C. with an onset at 137° C., e.g.,         an endothermic peak at 141° C. with an onset at 138° C.     -   1.159 Any of formulae 1.78-1.158 wherein the Crystalline Form B         exhibits a differential scanning calorimetry (DSC) thermogram as         shown in FIG. 8.     -   1.160 Any of formulae 1.78-1.159 wherein the Crystalline Form B         exhibits a thermogravimetric analysis (TGA) thermogram         comprising 0.2% weight loss up to 200° C.     -   1.161 Any of formulae 1.78-1.160 wherein the Crystalline Form B         exhibits a thermogravimetric analysis (TGA) thermogram         comprising an onset decomposition temperature at 281° C.     -   1.162 Any of formulae 1.78-1.161 wherein the Crystalline Form B         exhibits a thermogravimetric analysis (TGA) thermogram as shown         in FIG. 8.     -   1.163 Crystalline Form C of the Compound in hydrochloric acid         addition salt form         ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride) (“Crystalline Form C”).     -   1.164 Formula 1.163 wherein the Crystalline Form C exhibits an         XRPD pattern comprising a 2-theta (°) value of 17.7, wherein the         XRPD is measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.165 Formula 1.163 or 1.164 wherein the Crystalline Form C         exhibits an XRPD pattern having a characteristic 2-theta (°)         value of 17.7, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.166 Any of formulae 1.163-1.165 wherein the Crystalline Form C         exhibits an XRPD pattern comprising a 2-theta (°) value of         17.74, wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.167 Any of formulae 1.163-1.166 wherein the Crystalline Form C         exhibits an XRPD pattern having a characteristic 2-theta (°)         value of 17.74, wherein the XRPD is measured using an incident         beam of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the         XRPD is measured using radiation of wavelength 1.54059 Å.     -   1.168 Any of formulae 1.163-1.167 wherein the Crystalline Form C         exhibits an XRPD pattern comprising a 2-theta (°) value in Table         G below:

TABLE G °2θ d space (Å) Intensity (%) 17.74 ± 0.20 4.994 ± 0.056 100

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.169 Any of formulae 1.163-1.168 wherein the Crystalline Form C         exhibits an XRPD pattern having characteristic 2-theta (°) value         as set forth in Table G of formula 1.168, wherein the XRPD is         measured using an incident beam of Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å.     -   1.170 Any of formulae 1.163-1.169 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, 2-theta (°) values selected from the         group consisting of 7.0, 13.2, 14.4, 17.7, 18.0, 19.9, 21.3,         22.6, 23.7, and 26.5, wherein the XRPD is measured using an         incident beam of Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.171 Any of formulae 1.163-1.170 wherein the Crystalline Form C         exhibits an XRPD pattern comprising 2-theta (°) values of 7.0,         13.2, 14.4, 17.7, 18.0, 19.9, 21.3, 22.6, 23.7, and 26.5,         wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.172 Any of formulae 1.163-1.171 wherein the Crystalline Form C         exhibits an XRPD pattern having representative 2-theta (°)         values of 7.0, 13.2, 14.4, 17.7, 18.0, 19.9, 21.3, 22.6, 23.7,         and 26.5, wherein the XRPD is measured using an incident beam of         Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.173 Any of formulae 1.163-1.172 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, 2-theta (°)         values selected from the group consisting of 6.97, 13.24, 14.39,         17.74, 17.98, 18.03, 19.85, 21.32, 22.60, 23.68, and 26.52,         wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.174 Any of formulae 1.163-1.173 wherein the Crystalline Form C         exhibits an XRPD pattern comprising 2-theta (°) values of 6.97,         13.24, 14.39, 17.74, 17.98, 18.03, 19.85, 21.32, 22.60, 23.68,         and 26.52, wherein the XRPD is measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD         is measured using radiation of wavelength 1.54059 Å.     -   1.175 Any of formulae 1.163-1.174 wherein the Crystalline Form C         exhibits an XRPD pattern having representative 2-theta (°)         values of 6.97, 13.24, 14.39, 17.74, 17.98, 18.03, 19.85, 21.32,         22.60, 23.68, and 26.52, wherein the XRPD is measured using an         incident beam of Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.176 Any of formulae 1.163-1.175 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, 2-theta (°)         values selected from those set forth in Table H below:

TABLE H °2θ d space (Å) Intensity (%)  6.97 ± 0.20 12.677 ± 0.363  15 13.24 ± 0.20 6.683 ± 0.101 13 14.39 ± 0.20 6.150 ± 0.085 21 17.74 ± 0.20 4.994 ± 0.056 100 17.98 ± 0.20 4.929 ± 0.054 27 18.03 ± 0.20 4.915 ± 0.054 24 19.85 ± 0.20 4.470 ± 0.045 47 21.32 ± 0.20 4.164 ± 0.039 23 22.60 ± 0.20 3.931 ± 0.034 95 23.68 ± 0.20 3.754 ± 0.031 25 26.52 ± 0.20 3.359 ± 0.025 34

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.177 Any of formulae 1.163-1.176 wherein the Crystalline Form C         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table H of formula 1.176, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.178 Any of formulae 1.163-1.177 wherein the Crystalline Form C         exhibits an XRPD pattern having representative 2-theta (°)         values as set forth in Table H of formula 1.176, wherein the         XRPD is measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.179 Any of formulae 1.163-1.178 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, e.g., at least         eleven, e.g., at least fifteen, e.g., at least twenty, 2-theta         (°) values selected from the group consisting of 7.0, 13.2,         13.7, 14.0, 14.4, 16.3, 17.7, 18.0, 18.3, 19.9, 21.1, 21.3,         22.6, 23.4, 23.7, 23.9, 26.0, 26.5, 26.7, 26.9, 27.4, 28.0,         28.2, 29.1, and 29.5, wherein the XRPD is measured using an         incident beam of Cu radiation, e.g., Cu Kα radiation, e.g.,         wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.180 Any of formulae 1.163-1.179 wherein the Crystalline Form C         exhibits an XRPD pattern comprising the following 2-theta (°)         values:     -    7.0, 13.2, 13.7, 14.0, 14.4, 16.3, 17.7, 18.0, 18.3, 19.9,         21.1, 21.3, 22.6, 23.4, 23.7, 23.9, 26.0, 26.5, 26.7, 26.9,         27.4, 28.0, 28.2, 29.1, and 29.5,     -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.181 Any of formulae 1.163-1.180 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, e.g., at least         eleven, e.g., at least fifteen, e.g., at least twenty, e.g., at         least twenty-five, 2-theta (°) values selected from the group         consisting of 6.97, 13.24, 13.68, 13.97, 14.39, 16.29, 17.74,         17.98, 18.03, 18.30, 19.85, 21.06, 21.32, 22.60, 23.35, 23.68,         23.94, 25.99, 26.52, 26.66, 26.90, 27.40, 27.99, 28.19, 29.06,         and 29.52, wherein the XRPD is measured using an incident beam         of Cu radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD         is measured using radiation of wavelength 1.54059 Å.     -   1.182 Any of formulae 1.163-1.181 wherein the Crystalline Form C         exhibits an XRPD pattern comprising the following 2-theta (°)         values:     -    6.97, 13.24, 13.68, 13.97, 14.39, 16.29, 17.74, 17.98, 18.03,         18.30, 19.85, 21.06, 21.32, 22.60, 23.35, 23.68, 23.94, 25.99,         26.52, 26.66, 26.90, 27.40, 27.99, 28.19, 29.06, and 29.52,     -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.183 Any of formulae 1.163-1.182 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, e.g., at least         eleven, e.g., at least fifteen, e.g., at least twenty, e.g., at         least twenty-five, 2-theta (°) values selected from those set         forth in Table I below:

TABLE I °2θ d space (Å) Intensity (%)  6.97 ± 0.20 12.677 ± 0.363  15 13.24 ± 0.20 6.683 ± 0.101 13 13.68 ± 0.20 6.469 ± 0.094 2 13.97 ± 0.20 6.333 ± 0.090 3 14.39 ± 0.20 6.150 ± 0.085 21 16.29 ± 0.20 5.435 ± 0.066 6 17.74 ± 0.20 4.994 ± 0.056 100 17.98 ± 0.20 4.929 ± 0.054 27 18.03 ± 0.20 4.915 ± 0.054 24 18.30 ± 0.20 4.843 ± 0.052 13 19.85 ± 0.20 4.470 ± 0.045 47 21.06 ± 0.20 4.214 ± 0.040 6 21.32 ± 0.20 4.164 ± 0.039 23 22.60 ± 0.20 3.931 ± 0.034 95 23.35 ± 0.20 3.806 ± 0.032 14 23.68 ± 0.20 3.754 ± 0.031 25 23.94 ± 0.20 3.714 ± 0.031 13 25.99 ± 0.20 3.426 ± 0.026 14 26.52 ± 0.20 3.359 ± 0.025 34 26.66 ± 0.20 3.340 ± 0.025 16 26.90 ± 0.20 3.311 ± 0.024 14 27.40 ± 0.20 3.252 ± 0.023 6 27.99 ± 0.20 3.185 ± 0.022 6 28.19 ± 0.20 3.163 ± 0.022 3 29.06 ± 0.20 3.070 ± 0.021 5 29.52 ± 0.20 3.024 ± 0.020 7

-   -    wherein the XRPD is measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.54059 Å.     -   1.184 Any of formulae 1.163-1.183 wherein the Crystalline Form C         exhibits an XRPD pattern comprising the 2-theta (°) values set         forth in Table I of formula 1.183, wherein the XRPD is measured         using an incident beam of Cu radiation, e.g., Cu Kα radiation,         e.g., wherein the XRPD is measured using radiation of wavelength         1.54059 Å.     -   1.185 Any of formulae 1.163-1.184 wherein the Crystalline Form C         exhibits an XRPD pattern comprising a d-spacing (Å) value of         5.0.     -   1.186 Any of formulae 1.163-1.185 wherein the Crystalline Form C         exhibits an XRPD pattern comprising a d-spacing (Å) value of         4.99.     -   1.187 Any of formulae 1.163-1.186 wherein the Crystalline Form C         exhibits an XRPD pattern comprising a d-spacing (Å) value of         4.994.     -   1.188 Any of formulae 1.163-1.187 wherein the Crystalline Form C         exhibits an XRPD pattern comprising a d-spacing (Å) value in         Table G of formula 1.168.     -   1.189 Any of formulae 1.163-1.188 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, d-spacing (Å) values selected from         the group consisting of 12.7, 6.7, 6.2, 5.0, 4.9, 4.5, 4.2, 3.9,         3.8, and 3.4.     -   1.190 Any of formulae 1.163-1.189 wherein the Crystalline Form C         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.7, 6.7, 6.2, 5.0, 4.9, 4.5, 4.2, 3.9, 3.8, and 3.4.     -   1.191 Any of formulae 1.163-1.190 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, d-spacing (Å)         values selected from the group consisting of 12.68, 6.68, 6.15,         4.99, 4.93, 4.92, 4.47, 4.16, 3.93, 3.75, and 3.36.     -   1.192 Any of formulae 1.163-1.191 wherein the Crystalline Form C         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.68, 6.68, 6.15, 4.99, 4.93, 4.92, 4.47, 4.16, 3.93, 3.75, and         3.36.     -   1.193 Any of formulae 1.163-1.192 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, d-spacing (Å)         values selected from the group consisting of 12.677, 6.683,         6.150, 4.994, 4.929, 4.915, 4.470, 4.164, 3.931, 3.754, and         3.359.     -   1.194 Any of formulae 1.163-1.193 wherein the Crystalline Form C         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.677, 6.683, 6.150, 4.994, 4.929, 4.915, 4.470, 4.164, 3.931,         3.754, and 3.359.     -   1.195 Any of formulae 1.163-1.194 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, d-spacing (Å)         values selected from those set forth in Table H of formula         1.176.     -   1.196 Any of formulae 1.163-1.195 wherein the Crystalline Form C         exhibits an XRPD pattern comprising the d-spacing (Å) values set         forth in Table H of formula 1.176.     -   1.197 Any of formulae 1.163-1.196 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, e.g., at least         eleven, e.g., at least fifteen, d-spacing (Å) values selected         from the group consisting of 12.7, 6.7, 6.5, 6.3, 6.2, 5.4, 5.0,         4.9, 4.8, 4.5, 4.2, 3.9, 3.8, 3.7, 3.4, 3.3, 3.2, 3.1, and 3.0.     -   1.198 Any of formulae 1.163-1.197 wherein the Crystalline Form C         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.7, 6.7, 6.5, 6.3, 6.2, 5.4, 5.0, 4.9, 4.8, 4.5, 4.2, 3.9,         3.8, 3.7, 3.4, 3.3, 3.2, 3.1, and 3.0.     -   1.199 Any of formulae 1.163-1.198 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, e.g., at least         eleven, e.g., at least fifteen, e.g., at least twenty, e.g., at         least twenty-five, d-spacing (Å) values selected from the group         consisting of 12.68, 6.68, 6.47, 6.33, 6.15, 5.44, 4.99, 4.93,         4.92, 4.84, 4.47, 4.21, 4.16, 3.93, 3.81, 3.75, 3.71, 3.43,         3.36, 3.34, 3.31, 3.25, 3.19, 3.16, 3.07, and 3.02.     -   1.200 Any of formulae 1.163-1.199 wherein the Crystalline Form C         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.68, 6.68, 6.47, 6.33, 6.15, 5.44, 4.99, 4.93, 4.92, 4.84,         4.47, 4.21, 4.16, 3.93, 3.81, 3.75, 3.71, 3.43, 3.36, 3.34,         3.31, 3.25, 3.19, 3.16, 3.07, and 3.02.     -   1.201 Any of formulae 1.163-1.200 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, e.g., at least         eleven, e.g., at least fifteen, e.g., at least twenty, e.g., at         least twenty-five, d-spacing (Å) values selected from the group         consisting of 12.677, 6.683, 6.469, 6.333, 6.150, 5.435, 4.994,         4.929, 4.915, 4.843, 4.470, 4.214, 4.164, 3.931, 3.806, 3.754,         3.714, 3.426, 3.359, 3.340, 3.311, 3.252, 3.185, 3.163, 3.070,         and 3.024.     -   1.202 Any of formulae 1.163-1.201 wherein the Crystalline Form C         exhibits an XRPD pattern comprising d-spacing (Å) values of         12.677, 6.683, 6.469, 6.333, 6.150, 5.435, 4.994, 4.929, 4.915,         4.843, 4.470, 4.214, 4.164, 3.931, 3.806, 3.754, 3.714, 3.426,         3.359, 3.340, 3.311, 3.252, 3.185, 3.163, 3.070, and 3.024.     -   1.203 Any of formulae 1.163-1.202 wherein the Crystalline Form C         exhibits an XRPD pattern comprising at least one, e.g., at least         three, e.g., at least five, e.g., at least ten, e.g., at least         eleven, e.g., at least fifteen, e.g., at least twenty, e.g., at         least twenty-five, d-spacing (Å) values selected from those set         forth in Table I of formula 1.183.     -   1.204 Any of formulae 1.163-1.203 having an XRPD pattern         comprising the d-spacing (Å) values set forth in Table I of         formula 1.183.     -   1.205 Any of formulae 1.163-1.204 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern comprising         characteristic peaks of the XRPD pattern shown in FIG. 9,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.541871 Å.     -   1.206 Any of formulae 1.163-1.205 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern comprising         representative peaks of the XRPD pattern shown in FIG. 9,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.541871 Å.     -   1.207 Any of formulae 1.163-1.206 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         three peaks, in some embodiments, five peaks, selected from         those shown in FIG. 9.     -   1.208 Any of formulae 1.163-1.207 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising at         least one peak, e.g., at least five peaks, e.g., at least eleven         peaks, e.g., at least fifteen peaks, e.g., at least twenty         peaks, e.g., at least twenty-five peaks, selected from those         shown in FIG. 9.     -   1.209 Any of formulae 1.163-1.208 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, substantially         as shown in FIG. 9.     -   1.210 Any of formulae 1.163-1.209 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, as shown in         FIG. 9.     -   1.211 Any of formulae 1.163-1.210 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern comprising         characteristic peaks of the XRPD pattern shown in FIG. 11,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, e.g., wherein XRPD pattern also comprises         peaks of Crystalline Form A (e.g., a mixture of Crystalline         Forms A and C).     -   1.212 Any of formulae 1.163-1.211 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern comprising         representative peaks of the XRPD pattern shown in FIG. 11,         wherein the XRPD is measured using Cu radiation, e.g., Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, e.g., wherein XRPD pattern also comprises         peaks of Crystalline Form A (e.g., a mixture of Crystalline         Forms A and C).     -   1.213 Any of formulae 1.163-1.212 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, comprising three peaks, in some         embodiments, five peaks, selected from those shown in FIG. 11,         e.g., wherein XRPD pattern also comprises peaks of Crystalline         Form A (e.g., a mixture of Crystalline Forms A and C).     -   1.214 Any of formulae 1.163-1.213 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, comprising at least one peak, e.g., at         least five peaks, e.g., at least eleven peaks, e.g., at least         fifteen peaks, e.g., at least twenty peaks, e.g., at least         twenty-five peaks, selected from those shown in FIG. 11, e.g.,         wherein XRPD pattern also comprises peaks of Crystalline Form A         (e.g., a mixture of Crystalline Forms A and C).     -   1.215 Any of formulae 1.163-1.214 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, substantially as shown in FIG. 11,         e.g., wherein XRPD pattern also comprises peaks of Crystalline         Form A (e.g., a mixture of Crystalline Forms A and C).     -   1.216 Any of formulae 1.163-1.215 wherein the Crystalline Form C         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., a high-resolution X-ray         powder diffraction pattern measured using an incident beam of Cu         Kα radiation, e.g., wherein the XRPD is measured using radiation         of wavelength 1.54059 Å, as shown in FIG. 11, e.g., wherein XRPD         pattern also comprises peaks of Crystalline Form A (e.g., a         mixture of Crystalline Forms A and C).     -   1.217 Any of formulae 1.163-1.216 wherein the Crystalline Form C         exhibits an XRPD pattern comprising characteristic peaks of the         XRPD pattern as shown in any of FIGS. 11 and 43, e.g., FIG. 11,         e.g., FIG. 43, wherein the XRPD is measured using Cu radiation,         e.g., Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.218 Any of formulae 1.163-1.217 wherein the Crystalline Form C         exhibits an XRPD pattern comprising representative peaks of the         XRPD pattern as shown in any of FIGS. 11 and 43, e.g., FIG. 11,         e.g., FIG. 43, wherein the XRPD is measured using Cu radiation,         e.g., Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å.     -   1.219 Any of formulae 1.163-1.218 wherein the Crystalline Form C         exhibits an XRPD pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., a high-resolution X-ray powder         diffraction pattern measured using an incident beam of Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, comprising three peaks, in some         embodiments, five peaks, selected from those shown in any of         FIGS. 11 and 43, e.g., FIG. 11, e.g., FIG. 43.     -   1.220 Any of formulae 1.163-1.219 wherein the Crystalline Form C         exhibits an XRPD pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., a high-resolution X-ray powder         diffraction pattern measured using an incident beam of Cu Kα         radiation, e.g., wherein the XRPD is measured using radiation of         wavelength 1.54059 Å, comprising at least one peak, e.g., at         least five peaks, e.g., at least ten peaks, e.g., at least         eleven peaks, e.g., at least fifteen peaks, e.g., at least         twenty peaks, e.g., at least twenty-five peaks, selected from         those shown in any of FIGS. 11 and 43, e.g., FIG. 11, e.g., FIG.         43.     -   1.221 Any of formulae 1.163-1.220 wherein the Crystalline Form C         exhibits an XRPD pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å, substantially as shown in any         of FIGS. 11 and 43, e.g., FIG. 11, e.g., FIG. 43.     -   1.222 Any of formulae 1.163-1.221 wherein the Crystalline Form C         exhibits an XRPD pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.54059 Å, as shown in any of FIGS. 11         and 43, e.g., FIG. 11, e.g., FIG. 43.     -   1.223 Any of formulae 1.163-1.222 wherein the Crystalline Form C         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak between 247° C. and 248° C.,         e.g., between 247° C. and 248° C. with an onset at 246° C.     -   1.224 Any of formulae 1.163-1.223 wherein the Crystalline Form C         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 247° C., e.g., an endothermic         peak at 247° C. with an onset at 246° C.     -   1.225 Any of formulae 1.163-1.224 wherein the Crystalline Form C         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 248° C., e.g., an endothermic         peak at 248° C. with an onset at 246° C.     -   1.226 Any of formulae 1.163-1.225 wherein the Crystalline Form C         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 122° C., e.g, an endothermic         peak at 122° C. with an onset at 112° C.     -   1.227 Any of formulae 1.163-1.226 wherein the Crystalline Form C         exhibits a differential scanning calorimetry (DSC) thermogram         comprising an endothermic peak at 271° C.     -   1.228 Any of formulae 1.163-1.227 wherein the Crystalline Form C         exhibits a differential scanning calorimetry (DSC) thermogram as         shown in FIG. 12.     -   1.229 Any of formulae 1.163-1.228 wherein the Crystalline Form C         exhibits a thermogravimetric analysis (TGA) comprising 1.3%         weight loss up to 200° C.     -   1.230 Any of formulae 1.163-1.229 wherein the Crystalline Form C         exhibits a thermogravimetric analysis (TGA) thermogram         comprising an onset decomposition temperature at 266° C.     -   1.231 Any of formulae 1.163-1.230 wherein the Crystalline Form C         exhibits a thermogravimetric analysis (TGA) thermogram as shown         in FIG. 12.     -   1.232 A Crystalline Form of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride as described and/or made as in any of the         examples.     -   1.233 A Crystalline Form of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride having an X-ray powder diffraction and/or X-ray         crystal structure as depicted in any of the Figures.     -   1.234 The Crystalline Form of any of formulae 1.1-1.233 wherein         the XRPD pattern is measured using a copper source, e.g., a         copper anode.     -   1.235 A combination of any of the Crystalline Forms A through F,         e.g., any of formulae 1.1-1.234 and any of formulae 2.1-2.25,         e.g., a combination of Crystalline Form A and Crystalline Form         B; a combination of Crystalline Form A and Crystalline Form C; a         combination of Crystalline Form A, Crystalline Form B, and         Crystalline Form C; a combination of Crystalline Form B and         Crystalline Form C; a combination of Crystalline Form B and         Crystalline Form D; a combination of Crystalline Form E and         Crystalline Form F.     -   1.236 The Crystalline Form according to any of formulae         1.1-1.234, e.g., Crystalline Form A, e.g., any of formulae         1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae         1.78-1.162, wherein said Crystalline Form is free or         substantially free of any other form, e.g., less than 20 wt. %,         e.g., less than 15 wt. %, e.g., less than 10 wt. %, preferably         less than 5 wt. %, preferably less than 3 wt. %, more preferably         less than 2 wt. %, still preferably less than 1 wt. %, still         preferably less than 0.1 wt. %, most preferably less than 0.01         wt. %, of the amorphous form.     -   1.237 The Crystalline Form according to any of formulae         1.1-1.234, e.g., Crystalline Form A, e.g., any of formulae         1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae         1.78-1.162, wherein said Crystalline Form is free or         substantially free of any other form, e.g., less than 20 wt. %,         e.g., less than 10 wt. %, preferably less than 5 wt. %,         preferably less than 3 wt. %, more preferably less than 2 wt. %,         still preferably less than 1 wt. %, still preferably less than         0.1 wt. %, most preferably less than 0.01 wt. %, of any other         crystalline form.     -   1.238 The Crystalline Form according to any of formulae         1.1-1.234, e.g., Crystalline Form A, e.g., any of formulae         1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae         1.78-1.162, wherein said Crystalline Form is free or         substantially free of any other form, e.g., less than 20 wt. %,         e.g., less than 10 wt. %, preferably less than 5 wt. %,         preferably less than 3 wt. %, more preferably less than 2 wt. %,         still preferably less than 1 wt. %, still preferably less than         0.1 wt. %, most preferably less than 0.01 wt. %, of the         amorphous form and any other crystalline form.     -   1.239 The Crystalline Form according to any of formulae         1.1-1.238 when made by any of processes described in formula         4.1-4.20 or similarly described in any of the examples or having         an X-ray powder diffraction or X-ray crystal structure as         depicted in any of the Figures.

In the second aspect, the invention provides a citrate salt of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane.

In the third aspect, the invention provides a phosphate salt of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane.

In the fourth aspect, the invention provides a crystalline form as made or described in any of the examples or having an X-ray powder diffraction as depicted in any of the Figures, e.g.:

-   -   2.1 Crystalline Form D.     -   2.2 Formula 2.1 wherein the Crystalline Form D exhibits an X-ray         powder diffraction pattern, e.g., an X-ray powder diffraction         pattern measured using an incident beam of Cu radiation, e.g.,         Cu Kα radiation, e.g., wherein the XRPD is measured using         radiation of wavelength 1.541871 Å, comprising characteristic         peaks of the XRPD pattern shown in FIG. 15.     -   2.3 Formula 2.1 or 2.2 wherein the Crystalline Form D exhibits         an X-ray powder diffraction pattern, e.g., an X-ray powder         diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         representative peaks of the XRPD pattern shown in FIG. 15.     -   2.4 Any of formula 2.1-2.3 wherein the Crystalline Form D         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         three peaks, in some embodiments, five peaks, selected from         those shown in FIG. 15.     -   2.5 Any of formula 2.1-2.4 wherein the Crystalline Form D         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         ten peaks, in some embodiments twenty peaks, in some embodiments         twenty-five peaks, selected from those shown in FIG. 15.     -   2.6 Any of formula 2.1-2.5 wherein the Crystalline Form D         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, substantially         as shown in FIG. 15.     -   2.7 Any of formulae 2.1-2.6 wherein the Crystalline Form D         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, as shown in         FIG. 15.     -   2.8 Any of formulae 2.1-2.7 wherein the Crystalline Form D is a         citrate salt of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane.     -   2.9 Crystalline Form E.     -   2.10 Formula 2.9 wherein the Crystalline Form E exhibits an         X-ray powder diffraction pattern, e.g., an X-ray powder         diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         characteristic peaks of the XRPD pattern shown in FIG. 16.     -   2.11 Formula 2.9 or 2.10 wherein the Crystalline Form E exhibits         an X-ray powder diffraction pattern, e.g., an X-ray powder         diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         representative peaks of the XRPD pattern shown in FIG. 16.     -   2.12 Any of formula 2.9-2.11 wherein the Crystalline Form E         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         three peaks, in some embodiments, five peaks, selected from         those shown in FIG. 16.     -   2.13 Any of formula 2.9-2.12 wherein the Crystalline Form E         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         ten peaks, in some embodiments twenty peaks, in some embodiments         twenty-five peaks, selected from those shown in FIG. 16.     -   2.14 Any of formula 2.9-2.13 wherein the Crystalline Form E         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, substantially         as shown in FIG. 16.     -   2.15 Any of formulae 2.9-2.14 wherein the Crystalline Form E         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, as shown in         FIG. 16.     -   2.16 Any of formulae 2.9-2.15 wherein the Crystalline Form E is         a phosphate salt of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane.     -   2.17 Crystalline Form F.     -   2.18 Formula 2.17 wherein the Crystalline Form F exhibits an         X-ray powder diffraction pattern, e.g., an X-ray powder         diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         characteristic peaks of the XRPD pattern shown in FIG. 17.     -   2.19 Formula 2.17 or 2.18 wherein the Crystalline Form F         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         representative peaks of the XRPD pattern shown in FIG. 17.     -   2.20 Any of formula 2.17-2.19 wherein the Crystalline Form F         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         three peaks, in some embodiments, five peaks, selected from         those shown in FIG. 17.     -   2.21 Any of formula 2.17-2.20 wherein the Crystalline Form F         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, comprising         ten peaks, in some embodiments twenty peaks, in some embodiments         twenty-five peaks, selected from those shown in FIG. 17.     -   2.22 Any of formula 2.17-2.21 wherein the Crystalline Form F         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, substantially         as shown in FIG. 17.     -   2.23 Any of formulae 2.17-2.22 wherein the Crystalline Form F         exhibits an X-ray powder diffraction pattern, e.g., an X-ray         powder diffraction pattern measured using an incident beam of Cu         radiation, e.g., Cu Kα radiation, e.g., wherein the XRPD is         measured using radiation of wavelength 1.541871 Å, as shown in         FIG. 17.     -   2.24 Any of formulae 2.17-2.23 wherein the Crystalline Form F is         a phosphate salt of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane.     -   2.25 The Crystalline Form of any of formulae 2.1-2.24 wherein         the XRPD pattern is measured using a copper source, e.g., a         copper anode.     -   2.26 A combination of any of the Crystalline Forms A through F,         e.g., any of formulae 1.1-1.234 and any of formulae 2.1-2.25,         e.g., a combination of Crystalline Form A and Crystalline Form         B; a combination of Crystalline Form A and Crystalline Form C; a         combination of Crystalline Form A, Crystalline Form B, and         Crystalline Form C; a combination of Crystalline Form B and         Crystalline Form C; a combination of Crystalline Form B and         Crystalline Form D; a combination of Crystalline Form E and         Crystalline Form F.     -   2.27 The Crystalline Form according to any of formulae 2.1-2.25,         wherein said Crystalline Form is free or substantially free of         any other form, e.g., less than 20 wt. %, e.g., less than 15 wt.         %, e.g., less than 10 wt. %, preferably less than 5 wt. %,         preferably less than 3 wt. %, more preferably less than 2 wt. %,         still preferably less than 1 wt. %, still preferably less than         0.1 wt. %, most preferably less than 0.01 wt. %, of the         amorphous form.     -   2.28 The Crystalline Form according to any of formulae 2.1-2.25,         wherein said Crystalline Form is free or substantially free of         any other form, e.g., less than 20 wt. %, e.g., less than 10 wt.         %, preferably less than 5 wt. %, preferably less than 3 wt. %,         more preferably less than 2 wt. %, still preferably less than 1         wt. %, still preferably less than 0.1 wt. %, most preferably         less than 0.01 wt. %, of any other crystalline form.     -   2.29 The Crystalline Form according to any of formulae 2.1-2.25,         wherein said Crystalline Form is free or substantially free of         any other form, e.g., less than 20 wt. %, e.g., less than 10 wt.         %, preferably less than 5 wt. %, preferably less than 3 wt. %,         more preferably less than 2 wt. %, still preferably less than 1         wt. %, still preferably less than 0.1 wt. %, most preferably         less than 0.01 wt. %, of the amorphous form and any other         crystalline form.     -   2.30 The Crystalline Form according to any of formulae 2.1-2.29         when made by any of processes described in formula 4.1-4.20 or         similarly described in any of the examples or having an X-ray         powder diffraction or X-ray crystal structure as depicted in any         of the Figures.

Phase transitions of solids can be thermodynamically reversible or irreversible. Crystalline forms that transform reversibly at a specific transition temperature (T_(t)) are enantiotropic polymorphs. If the crystalline forms are not interconvertible under these conditions, the system is monotropic (one thermodynamically stable form).

Crystalline Forms A, B, and C are anhydrous enantiotropes of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride. Crystalline Form C is the stable solid phase below the transition temperature T_(t,C→B), Crystalline Form B is the stable solid phase between T_(t,C→B) and T_(t,B→A), and Crystalline Form A is the stable solid phase above T_(t,B→A). T_(t,C→B) is expected below 2° C. T_(t,C→A) will be between 2° C. and ambient temperature, and T_(t,B→A) is between 37 and 54° C.

Owing to kinetic constraints, the thermodynamic transformation of Crystalline Form A to Crystalline Form B is hindered. Therefore, surprisingly, Crystalline Form A appears to be sufficiently kinetically stable so as to persist in the solid state under temperature conditions where it is thermodynamically metastable.

Agitating Crystalline Form A as a slurry for 16 days in dichloromethane at ambient temperature (see Example 6a) does not cause a solvent mediated form conversion to Crystalline Form B, the more stable form at that temperature. This indicates that the critical free energy barrier for nucleation is not overcome in the absence of seeds of the more stable polymorph within the time frame evaluated.

Under exposure to accelerated stress conditions for two weeks, Crystalline Forms A and B remain unchanged at 30° C./56% RH or 40° C./75% RH (Example 11). In contrast, Crystalline Form C converts to a mixture of Crystalline Forms A and B within two weeks at 40° C./75% RH (Example 11). Thus, unlike Crystalline Form A, Crystalline Form C converts under conditions in which it is metastable.

For Crystalline Form A, in the absence of seeds of the more stable polymorph, the critical free energy barrier for the nucleation of Crystalline Form B is not overcome in the solid state or in solvent mediated conversion experiments within the time evaluated.

Thus, Crystalline Form A may be synthesized on large scale easily, yet, also, surprisingly, persists in the solid state even under conditions in which it is thermodynamically metastable.

In the fifth aspect, the invention provides the following:

-   -   3.1. A pharmaceutical composition comprising any of the         Crystalline Form A through F according to any of formulae         1.1-1.239 or 2.1-2.30, e.g., Crystalline Form A, e.g., any of         formulae 1.1-1.77, e.g., Crystalline Form B, e.g., any of         formulae 1.78-1.162, and a pharmaceutically acceptable diluent         or carrier.     -   3.2. The pharmaceutical composition according to formula 3.1,         wherein the composition is sustained release.     -   3.3. The pharmaceutical composition according to formula 3.1 or         3.2, comprising 1 mg to 1800 mg, e.g., 10 mg to 1800 mg, e.g.,         25 mg to 1800 mg, e.g., 10 mg to 1600 mg, e.g., 10 mg to 1200         mg, e.g., 50 mg to 1200 mg, e.g., 50 mg to 1000 mg, e.g., 75 mg         to 1000 mg, e.g., 75 mg to 800 mg, e.g., 75 mg to 500 mg, e.g.,         100 mg to 750 mg, e.g., 100 mg to 500 mg, e.g., 100 mg to 400         mg, e.g., 100 mg to 300 mg, e.g., 100 mg to 200 mg, of any of         the Crystalline Form A through F of the invention, e.g., any of         formulae 1.1-1.239, e.g., Crystalline Form A, e.g., any of         formulae 1.1-1.77, e.g., Crystalline Form B, e.g., any of         formulae 1.78-1.162, e.g., any of formulae 2.1-2.30.     -   3.4. The composition of any one of formulae 3.1-3.3 comprising         75 mg to 1000 mg, e.g., 100 mg to 600 mg, e.g., 100 mg to 400         mg, e.g., 100 mg to 200 mg, of any of the Crystalline Form A         through F of the invention, e.g., any of formulae 1.1-1.239,         e.g., Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g.,         Crystalline Form B, e.g., any of formulae 1.78-1.162, e.g., any         of formulae 2.1-2.30.     -   3.5. The composition of any one of formulae 3.1-3.3 comprising         50 mg to 600 mg, e.g., 100 mg to 600 mg, e.g., 100 mg to 400 mg,         e.g., 100 mg to 200 mg, of any of the Crystalline Form A through         F of the invention, e.g., any of formulae 1.1-1.239, e.g.,         Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g.,         Crystalline Form B, e.g., any of formulae 1.78-1.162, e.g., any         of formulae 2.1-2.30.     -   3.6. The composition of any one of formulae 3.1-3.3 comprising 5         mg to 500 mg, e.g., 5 mg to 10 mg, e.g., 10 mg to 25 mg, e.g.,         30 mg to 50 mg, e.g., 10 mg to 300 mg, e.g., 25 mg to 300 mg,         e.g., 50 mg to 100 mg, e.g., 100 mg to 250 mg, e.g., 250 mg to         500 mg, of any one of Crystalline Forms A through F of the         invention, e.g., e.g., any of formulae 1.1-1.239, e.g.,         Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g.,         Crystalline Form B, e.g., any of formulae 1.78-1.162, e.g., any         of formulae 2.1-2.30.     -   3.7. The composition of any one of formulae 3.1-3.3 for         administration of 0.5 mg/kg to 20 mg/kg per day, e.g., 1 mg/kg         to 15 mg/kg per day, e.g., 1 mg/kg to 10 mg/kg per day, e.g., 2         mg/kg to 20 mg/kg per day, e.g., 2 mg/kg to 10 mg/kg per day,         e.g., 3 mg/kg to 15 mg/kg per day, of any of the Crystalline         Form A through F of the invention, e.g., any of formulae         1.1-1.239, e.g., Crystalline Form A, e.g., any of formulae         1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae         1.78-1.162, e.g., any of formulae 2.1-2.30.     -   3.8. The composition of any one of formulae 3.1-3.7 comprising         less than 50% w/w of any one of Crystalline Forms A through F of         the invention, e.g., less than 40% w/w, e.g., less than 30% w/w,         less than 20% w/w, e.g., 1-40% w/w, e.g., 5-40% w/w, e.g.,         10-30% w/w, e.g., 15-25% w/w, e.g., 15-20% w/w, e.g., 17% w/w,         e.g., 25% w/w, e.g., any of formulae 1.1-1.239, e.g.,         Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g.,         Crystalline Form B, e.g., any of formulae 1.78-1.162, e.g., any         of formulae 2.1-2.30.     -   3.9. The composition of any one of formulae 3.1-3.8 wherein the         pharmaceutically acceptable diluent or carrier comprises         hydroxypropyl methylcellulose.     -   3.10. The composition of formula 3.9, wherein the composition         comprises at least 10% w/w of the hydroxypropyl methylcellulose,         e.g., 10-50% w/w, e.g., 10-40% w/w, e.g., 20-50% w/w, e.g.,         20-40% w/w, e.g., 30-40% w/w, e.g., 37% w/w.     -   3.11. The composition of formula 3.9 or 3.10, wherein the degree         of methoxy substitution of the hydroxypropyl methylcellulose is         19-24%.     -   3.12. The composition of any one of formulae 3.9-3.11, wherein         the degree of hydroxypropoxy substitution of the hydroxypropyl         methylcellulose is 4-12%.     -   3.13. The composition of any one of formulae 3.9-3.12, wherein         the hydroxypropyl methylcellulose is hypromellose 2208.     -   3.14. The composition of any one of formulae 3.9-3.13, wherein         the hydroxypropyl methylcellulose has a nominal viscosity of         4,000 mPA·σ.     -   3.15. The composition of any one of formulae 3.9-3.13, wherein         the hydroxypropyl methylcellulose has a viscosity of 2,000-6,000         mPA·σ, e.g., 2,600 to 5,000 mPA·σ, e.g., 2,663 to 4,970 mPA·σ.     -   3.16. The composition of any one of formulae 3.9-3.15, wherein         the pharmaceutically acceptable diluent or carrier comprises         alpha-lactose monohydrate.     -   3.17. The composition of formula 3.16, wherein the composition         comprises at least 10% w/w of the alpha-lactose monohydrate,         e.g., 10-80% w/w, e.g., 20-70% w/w, e.g., 20-60% w/w, e.g.,         20-50% w/w, e.g., 20-40% w/w, e.g., 20-30% w/w, e.g., 30-70%         w/w, e.g., 30-60% w/w, e.g., 30-50% w/w, e.g., 30%-40% w/w,         e.g., 37% w/w.     -   3.18. The composition of formula 3.16 or 3.17, wherein the         composition comprises milled alpha-lactose monohydrate.     -   3.19. The composition of any one of formulae 3.1-3.18, wherein         the composition comprises a co-processed mixture of         hydroxypropyl methylcellulose and alpha-lactose monohydrate         (e.g., Retalac®     -   3.20. The composition of formula 3.19, wherein the mixture         comprises equal parts of the hydroxypropyl methylcellulose and         alpha-lactose monohydrate.     -   3.21. The composition of formula 3.19 or 3.20, wherein the         mixture comprises particles of hydroxypropyl methylcellulose and         alpha-lactose monohydrate with d₅₀ (median diameter) in the         range of 100 μm to 200 μm, e.g., 125 μm.     -   3.22. The composition of any one of formulae 3.19-3.21, wherein         the mixture comprises particles of hydroxypropyl methylcellulose         and alpha-lactose monohydrate wherein the particle size         distribution is as follows:         -   <63 μm≤25%         -   <100 μm: 35%         -   <250 μm≥80%.     -   3.23. The composition of any one of formulae 3.19-3.22, wherein         the composition comprises at least 20% w/w of the mixture, e.g.,         at least 30% w/w, e.g., at least 40% w/w, e.g., at least 50%         w/w, e.g., at least 60% w/w, e.g., at least 70% w/w, e.g, at         least 80% w/w, e.g., 20-90% w/w, e.g., 30-80% w/w, e.g., 40-80%         w/w, e.g., 50-80% w/w, e.g., 60-80% w/w, e.g., 70-80% w/w, e.g.,         75% w/w.     -   3.24. The composition of any one of formulae 3.1-3.23, wherein         the pharmaceutically acceptable diluent or carrier comprises a         lubricant, e.g., magnesium stearate.     -   3.25. The composition of formula 3.24, wherein the lubricant is         one or more of glyceryl behenate, magnesium stearate, talc, and         sodium stearyl fumarate, e.g, magnesium stearate.     -   3.26. The composition of formula 3.24 or 3.25, wherein the         composition comprises less than 10% w/w of the lubricant, e.g.,         less than 5% w/w, less than 3% w/w, less than 1% w/w, e.g., 0.1         to 1% w/w, e.g., 0.1 to 0.8% w/w, e.g., 0.5% w/w.     -   3.27. The composition of any one of formulae 3.24-3.26, wherein         the composition comprises less than 10% w/w of magnesium         stearate, e.g., less than 5% w/w, less than 3% w/w, less than 1%         w/w, e.g., 0.1 to 1% w/w, e.g., 0.1 to 0.8% w/w, e.g., 0.5% w/w.     -   3.28. The composition of any one of formulae 3.1-3.27, wherein         the pharmaceutically acceptable diluent or carrier comprises one         or more of a diluent, disintegrant, binder, and modified release         agent.     -   3.29. The composition of formula 3.28, wherein the diluent is         one or more of mannitol (e.g., Pearlitol 300 DC),         micro-crystalline cellulose (e.g., Avicel pH 102), and         pre-gelatinized starch (e.g., Starch 1500).     -   3.30. The composition of formula 3.29, wherein the disintegrant         is one or both of crospovidone (e.g., Polyplasdone XL-10) and         sodium starch glycolate (e.g., Explotab).     -   3.31. The composition of formula 3.28, wherein the binder is         polyvinylpyrrolidone (e.g., Povidone K29/32).     -   3.32. The composition of formula 3.28, wherein the modified         release agent is one or more of hydroxypropyl cellulose (e.g.,         Klucel EXF, Klucel MXF, and/or Klucel HXF) and hydroxypropyl         methylcellulose (e.g., Methocel K100M, Methocel K4M PREM,         Methocel K15M PREM CR).     -   3.33. The composition of formula 3.28 or 3.32, wherein the         composition comprises at least 5% w/w of the modified release         agent, e.g., 5-60% w/w, e.g., 10-50% w/w, e.g., 10-40% w/w.     -   3.34. The composition of formula 3.32 or 3.33, wherein the         modified release agent is hydroxypropyl methylcellulose.     -   3.35. A method for the prophylaxis or treatment of a disorder         and/or alleviation of associated symptoms of any disorder         treatable by inhibiting reuptake of multiple biogenic amines         causally linked to the targeted CNS disorder, wherein the         biogenic amines targeted for reuptake inhibition are selected         from norepinephrine, and/or serotonin, and/or dopamine, in a         particular embodiment, a method for the prophylaxis or treatment         of any of the following disorders:         -   (i) attention deficit hyperactivity disorder (ADHD, both             pediatric and adult) and related behavioral disorders, as             well as forms and symptoms of alcohol abuse, drug abuse,             obsessive compulsive disorder, learning disorders, reading             problems, gambling addiction, manic symptoms, phobias, panic             attacks, oppositional defiant disorder, conduct disorder,             disruptive behavior disorder, academic problems in school,             smoking, abnormal sexual behaviors, schizoid behaviors,             somatization, depression (including but not limited to major             depressive disorder, recurrent; dysthymic disorder;             depressive disorder not otherwise specified (NOS); major             depressive disorder, single episode; depression associated             with bipolar disorder, Alzheimers, psychosis or Parkinson's             disease; postnatal depression; and seasonal affected             disorder), sleep disorders, generalized anxiety, stuttering,             and tic disorders (such as Tourette's syndrome);         -   (ii) ADHD, substance abuse, depression, anxiety disorders             (including but not limited to panic disorder, generalized             anxiety, obsessive compulsive disorder, post-traumatic             stress disorder, and social anxiety disorder), autism,             traumatic brain injury, cognitive impairment, schizophrenia             (particularly for cognition), obesity, chronic pain             disorders, personality disorder, and mild cognitive             impairment;         -   (iii) anxiety, panic disorder, posttraumatic stress             disorder, obsessive compulsive disorder, schizophrenia and             allied disorders, obesity, tic disorders, addiction,             Parkinson's disease, and chronic pain;         -   (iv) substance abuse disorders (including but not limited to             alcohol-related disorders, nicotine-related disorders,             amphetamine-related disorders, cannabis-related disorders,             cocaine-related disorders, hallucinogen-use disorders,             inhalant-related disorders, and opioid-related disorders);         -   (v) cognitive disorders, bipolar disorder, anorexia nervosa,             bulimia nervosa, cyclothymic disorder, chronic fatigue             syndrome, chronic or acute stress, fibromyalgia and other             somatoform disorders (including somatization disorder,             conversion disorder, pain disorder, hypochondriasis, body             dysmorphic disorder, undifferentiated somatoform disorder,             somatoform NOS), incontinence (i.e., stress incontinence,             genuine stress incontinence, and mixed incontinence),             inhalation disorders, mania, migraine headaches, peripheral             neuropathy;         -   (vi) addictive disorders (including but not limited to             eating disorders, impulse control disorders, alcohol-related             disorders, nicotine-related disorders, amphetamine-related             disorders, cannabis-related disorders, cocaine-related             disorders, hallucinogen use disorders, inhalant-related             disorders, opioid-related disorders);         -   (vii) fragile X-associated disorder;         -   (viii) autism spectrum disorder (ASD), e.g., in a patient             with a fragile X-associated disorder;         -   (ix) ADHD in a patient with a fragile X-associated disorder;         -   (x) co-morbid ADHD and depression;         -   (xi) co-morbid ADHD and substance abuse;         -   (xii) co-morbid ADHD and anxiety;     -    comprising administering to a patient in need thereof a         therapeutically effective amount of any of Crystalline Form A         through F according to any of formulae 1.1-1.239, e.g.,         Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g.,         Crystalline Form B, e.g., any of formulae 1.78-1.162, e.g., any         of formulae 2.1-2.30, or a pharmaceutical composition according         to any of formulae 3.1-3.34.     -   3.36. A pharmaceutical composition according to any of formulae         3.1-3.34 for use as a medicament, e.g., for use in the         manufacture of a medicament for the treatment or prophylaxis of         any of the disorders described in formula 3.35.     -   3.37. Crystalline Form A through F according to any of formulae         1.1-1.239, e.g., Crystalline Form A, e.g., any of formulae         1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae         1.78-1.162, e.g., any of formulae 2.1-2.30, for use in the         prophylaxis or treatment of any of the disorders described in         formula 3.35, or for use in the manufacture of a medicament for         the treatment or prophylaxis of any of the disorders described         in formula 3.35.

In the sixth aspect, the invention provides the Crystalline Form according to any of formulae 1.1-1.239 or any of formulae 2.1-2.30 when made by any of the processes described or similarly described as follows:

-   -   4.1 Adding water to the Compound in hydrochloric acid addition         salt form ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride);     -    heating to dissolve all solids, e.g., heating to an internal         temperature between 30-40° C., e.g., 34° C.;     -    adding an organic solvent, e.g., tetrahydrofuran and/or         isopropylacetate;     -    separating aqueous layer;     -    adding base, e.g., aqueous ammonia, to the aqueous layer;     -    adding an organic solvent, e.g., isopropylacetate;     -    agitating, e.g., for a minimum of 15 minutes;     -    allowing layers to settle, e.g., for a minimum of 30 minutes;     -    separating organic layer;     -    drying organic layer, e.g., with magnesium sulphate;     -    filtering;     -    washing filtercake with an organic solvent, e.g.,         isopropylacetate;     -    concentrating filtrate and washes;     -    adding isopropyl alcohol;     -    stirring at room temperature to dissolve all solids;     -    adding hydrochloric acid, e.g., HCl in isopropanol, to form         solids, e.g., adding HCl over 10 minutes, e.g., adding HCl in         isopropanol over 10 minutes;     -    adding additional hydrochloric acid, e.g., HCl in isopropanol,         e.g., adding additional HCl over 55 minutes, e.g., adding HCl in         isopropanol over 55 minutes;     -    stirring slurry, e.g., stirring slurry for 35 minutes;     -    adding additional hydrochloric acid, e.g., HCl in isopropanol,         e.g., adding additional HCl over 10 minutes, e.g., adding HCl in         isopropanol over 10 minutes;     -    stirring slurry, e.g., stirring slurry for 30 minutes;     -    filtering;     -    washing filtercake with an organic solvent, e.g., isopropyl         alcohol; and     -    drying filtercake.     -   4.2 Storing Crystalline Form A at 40° C./75% RH, e.g., storing         Crystalline Form A at 40° C./75% RH for 7 days; and     -    isolating crystals.     -   4.3 Preparing a solution of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A, e.g., in chloroform,         dichloromethane, hexafluoroisopropylalcohol, methanol, and/or         2,2,2,-trifluoroethanol (TFE);     -    sonicating;     -    achieving complete dissolution as judged by visual observation;     -    filtering;     -    evaporating at ambient conditions, e.g., in a vial covered with         aluminium foil perforated with pinholes; and     -    isolating crystals.     -   4.4 Preparing a solution of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A, e.g., in chloroform,         dichloromethane, ethanol, and/or methanol;     -    filtering;     -    admixing with antisolvent, e.g., toluene, heptane,         acetonitrile, methyl ethyl ketone, acetone, hexanes,         tetrahydrofuran, dioxane, ethyl acetate, and/or isopropyl ether;         and     -    isolating crystals.     -   4.5 Exposing         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A, to vapor, e.g., organic         solvent vapor, e.g., dichloromethane and/or ethanol vapor; and     -    isolating crystals.     -   4.6 Preparing a suspension of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A, e.g., in         dichloromethane, ethanol, isopropyl alcohol, 1-propanol, and/or         water;     -    agitating at ambient temperature or elevated temperature; and     -    isolating crystals, e.g., by vacuum filtration.     -   4.7 Preparing a solution of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A, at elevated temperature         in an organic solvent, e.g., dichloromethane, ethanol, isopropyl         alcohol, and/or 1-propanol;     -    filtering, e.g., through 0.2 μm nylon filter, into a warm vial;     -    cooling;     -    optionally further cooling by placing in a refrigerator and/or         freezer; and     -    isolating crystals.     -   4.8 Preparing a solution of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A, at elevated temperature         in an organic solvent, e.g., dichloromethane, ethanol, isopropyl         alcohol, and/or 1-propanol; filtering, e.g., through 0.2 μm         nylon filter, into a cooled vial;     -    cooling below 0° C., e.g., placing in −78° C. bath, e.g., an         isopropyl alcohol/dry ice bath;     -    optionally further cooling by placing in a freezer; and     -    isolating crystals.     -   4.9 Preparing a solution of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A in an organic solvent,         e.g., ethanol, isopropyl alcohol, methanol, acetone, toluene,         1-propanol, water, and/or dioxane;     -    sonicating;     -    achieving complete dissolution as judged by visual observation;     -    filtering, e.g., through 0.2 μm nylon filter;     -    evaporating at ambient temperature; and     -    isolating crystals.     -   4.10 Preparing a solution or suspension of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A in an organic solvent,         e.g., dichloromethane, ethanol, isopropyl alcohol, and/or         1-propanol;     -    cooling, e.g, in a freezer; and     -    isolating crystals.     -   4.11 Preparing a solution or suspension of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride, e.g., Crystalline Form A in an organic solvent,         e.g., hexafluoroisopropyl alcohol and/or 2,2,2-trifluoroethanol;     -    filtering, e.g., through 0.2 μm nylon filter;     -    adding anti-solvent, e.g., an organic anti-solvent, e.g.,         isopropyl ether, tetrahydrofuran, acetonitrile, ethyl acetate,         and/or methyl ethyl ketone, until precipitation; and     -    isolating crystals, e.g., by vacuum filtration.     -   4.12 Dissolving         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in an         organic solvent, e.g., isopropanol;     -    adding HCl, eg., HCl in isopropanol; and     -    optionally filtering.     -   4.13 Seeding a solution or slurry with crystals of the desired         form, e.g., seeding a solution or slurry with Crystalline Form         A, e.g., seeding while the temperature of the solution or slurry         is above room temperature, e.g., 65° C.     -   4.14 Dissolving a solution of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride in an organic solvent, e.g., ethanol, while         heating, e.g., to 70° C.;     -    optionally filtering, e.g., via an encapsulated carbon filter;     -    optionally concentrating, e.g., to 5 total volumes (relative to         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride input);     -    optionally reheating to redissolve any solids;     -    optionally cooling, e.g., cooling to 65° C.;     -    seeding the solution;     -    optionally stirring to develop the seed bed;     -    optionally cooling; and     -    optionally filtering.     -   4.15 Dissolving         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride in water, e.g., with heat, e.g., heating to an         internal temperature between 30-40° C., e.g., 34° C.;     -    washing the aqueous solution;     -    adding a base, e.g., ammonia;     -    extracting         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane with an         organic solvent, e.g., isopropyl acetate;     -    optionally drying, e.g., over magnesium sulphate;     -    optionally concentrating to yield a solid;     -    optionally adding an organic solvent to dissolve the solid,         e.g., isopropanol; and     -    adding HCl, e.g., HCl in isopropanol;     -    optionally filtering; and     -    optionally washing with an organic solvent, e.g., isopropanol.     -   4.16 Dissolving a solution of         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride in an organic solvent, e.g., ethanol, while         heating, e.g., to 70° C.;     -    optionally filtering, e.g., via an encapsulated carbon filter;     -    concentrating, e.g., to 5 total volumes (relative to         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane         hydrochloride input);     -    optionally seeding before or after concentrating; and     -    optionally filtering.     -   4.17 Dissolving         (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in an         organic solvent;     -    adding HCl, e.g., HCl in isopropanol; and     -    optionally filtering.     -   4.18 Any of processes 4.1-4.17 further comprising isolating the         Crystalline Form, e.g., any of formulae 1.1-1.239 or 2.1-2.30,         e.g., Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g.         Crystalline Form B, e.g., any of formulae 1.78-1.162.     -   4.19 A Crystalline Form according to any of formulae 1.1-1.239         or 2.1-2.30 when made by any of Examples 1-3, e.g., Example 1.     -   4.20 A Crystalline Form according to any of formulae 1.1-1.239         or 2.1-2.30 when made by any of the syntheses described in the         Examples, e.g., Example 1, e.g., e.g., Example 3, e.g., any of         Examples 6-13, e.g., Example 17, e.g., Example 18.

In the seventh aspect, the invention provides a process for making Crystalline Form A through F according to any of formulae 1.1-1.239 or 2.1-2.30, e.g., Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae 1.78-1.162, by any process described in any of formula 4.1-4.20 or described in any of the Examples.

In the eight aspect, the invention provides a process for making a pharmaceutical composition comprising any of the Crystalline Form A through F according to any of formulae 1.1-1.239 or 2.1-2.30, e.g., Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae 1.78-1.162, e.g., a pharmaceutical composition according to any of formula 3.1-3.34, wherein the process comprises:

isolating any of the Crystalline Form A through F according to any of formulae 1.1-1.239 or 2.1-2.30, e.g., Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g., Crystalline Form B, e.g., any of formulae 1.78-1.162, and

admixing the isolated Crystalline Form with a pharmaceutically acceptable diluent or carrier.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts a high-resolution X-ray powder diffraction (XRPD) pattern of Crystalline Form A.

FIG. 2 depicts DSC and TGA thermograms of Crystalline Form A.

FIG. 3 depicts dynamic vapor sorption/desorption isotherm of Crystalline Form A.

FIG. 4 depicts an overlay of X-ray powder diffraction (XRPD) patterns of Crystalline Form A, Form B, and Form C (from top to bottom):

FIG. 4A depicts a high resolution X-ray powder diffraction pattern of Crystalline Form A;

FIG. 4B depicts an X-ray powder diffraction pattern of Crystalline Form B; and

FIG. 4C depicts an X-ray powder diffraction pattern of Crystalline Form C.

FIG. 5 depicts an X-ray powder diffraction (XRPD) pattern of Crystalline Form B.

FIG. 6 depicts an indexing solution for Crystalline Form B.

FIG. 7 depicts a high-resolution X-ray powder diffraction (XRPD) pattern of Crystalline Form B.

FIG. 8 depicts DSC and TGA thermograms of Crystalline Form B.

FIG. 9 depicts an X-ray powder diffraction (XRPD) pattern of Crystalline Form C.

FIG. 10 depicts an indexing solution for Crystalline Form C.

FIG. 11 depicts a high-resolution X-ray powder diffraction (XRPD) pattern of Crystalline Form C.

FIG. 12 depicts DSC and TGA thermograms of Crystalline Form C.

FIG. 13 depicts an overlay of X-ray powder diffraction (XRPD) patterns of Crystalline Form A, Form B, and Form C (from top to bottom):

FIG. 13A depicts an X-ray powder diffraction pattern of Crystalline Form B (slow cooling in IPA, solids precipitate in refrigerator);

FIG. 13B depicts an X-ray powder diffraction pattern of Crystalline Form C+Crystalline Form B (slow crystalline cooling in IPA, with seeds, solids precipitate in freezer);

FIG. 13C depicts an X-ray powder diffraction pattern of Crystalline Form C+Crystalline Form A (slow cooling in IPA, solids precipitate in freezer);

FIG. 13D depicts an X-ray powder diffraction pattern of Crystalline Form B (slow cooling in IPA, solids precipitate in freezer);

FIG. 13E depicts an X-ray powder diffraction pattern of Crystalline Form B+Crystalline Form A (crash cooling in IPA, solids precipitate in dry ice/IPA);

FIG. 13F depicts an X-ray powder diffraction pattern of Crystalline Form A+Crystalline Form C (slow cooling in IPA, solids precipitate in freezer); and

FIG. 13G depicts an X-ray powder diffraction pattern of Crystalline Form C, slow cooling in IPA.

FIG. 14 depicts an overlay of X-ray powder diffraction (XRPD) patterns of Crystalline Form D, Form E, and Form F (from top to bottom):

FIG. 14D depicts an X-ray powder diffraction pattern of Crystalline Form D (30-min stir at 70° C. in pH 4.4 buffer);

FIG. 14E depicts an X-ray powder diffraction pattern of Crystalline Form E (contains peaks of Crystalline Form F, slurry at 50° C. in pH 6.0 buffer); and

FIG. 14F depicts an X-ray powder diffraction pattern of Crystalline Form F (30-min stir at 70° C. in pH 8.1 buffer).

FIG. 15 depicts an X-ray powder diffraction (XRPD) pattern of Crystalline Form D.

FIG. 16 depicts an X-ray powder diffraction (XRPD) pattern of Crystalline Form E (contains peaks of Crystalline Form F).

FIG. 17 depicts an X-ray powder diffraction (XRPD) pattern of Crystalline Form F.

FIG. 18 depicts an ORTEP drawing of Crystalline Form A. Atoms are represented by 50% probability anisotropic thermal ellipsoids.

FIG. 19 depicts a packing diagram of Crystalline Form A viewed down the crystallographic a axis.

FIG. 20 depicts a packing diagram of Crystalline Form A viewed down the crystallographic b axis.

FIG. 21 depicts a packing diagram of Crystalline Form A viewed down the crystallographic c axis.

FIG. 22 depicts hydrogen bonding in Crystalline Form A.

FIG. 23 depicts a calculated X-ray powder diffraction (XRPD) pattern of Crystalline Form A.

FIG. 24 depicts an atomic displacement ellipsoid drawing for Crystalline Form B (atoms are represented by 50% probability anisotropic thermal ellipsoids).

FIG. 25 depicts a packing diagram of Crystalline Form B viewed along the crystallographic a axis.

FIG. 26 depicts a packing diagram of Crystalline Form B viewed along the crystallographic b axis.

FIG. 27 depicts a packing diagram of Crystalline Form B viewed along the crystallographic c axis.

FIG. 28 depicts hydrogen bonding in the structure of Crystalline Form B.

FIG. 29 depicts the molecular conformations of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in the structures of Crystalline Forms A and B (left: (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in the structure of Crystalline Form A; right: (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in the structure of Crystalline Form B).

FIG. 30 depicts a packing diagram of Crystalline Forms A and B viewed along the crystallographic a axis (left: packing of Crystalline Form A; right: packing of Crystalline Form B).

FIG. 31 depicts hydrogen bonding in the structures of Crystalline Forms A and B (left: hydrogen bonding in the structure of Crystalline Form A; right: hydrogen bonding in the structure of Form B).

FIG. 32 depicts a calculated X-ray powder pattern of Crystalline Form B.

FIG. 33 depicts experimental and calculated XRPD patterns of Crystalline Form B (top: experimental XRPD pattern at room temperature; middle: calculated XRPD pattern adjusted to room temperature; bottom: calculated XRPD pattern at 100 K).

FIG. 34 depicts experimental and calculated XRPD patterns of Crystalline Form A (top: calculated XRPD pattern; bottom: experimental XRPD pattern at room temperature).

FIG. 35 depicts an XRPD pattern of Crystalline Form A.

FIG. 36 depicts an XRPD pattern comparison of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride from Examples 1 and 5 (top: Example 5; bottom: Example 1) (patterns are offset along the y-axis for comparison).

FIG. 37 depicts an XRPD pattern of Crystalline Form A collected with Cu Kα radiation.

FIG. 38 depicts an indexing result for the XRPD pattern depicted in FIG. 37 collected with Cu Kα radiation.

FIG. 39 depicts observed peaks for the XRPD pattern depicted in FIG. 37 collected with Cu Kα radiation.

FIG. 40 depicts an XRPD pattern of Crystalline Form B.

FIG. 41 depicts an indexing result for the XRPD pattern depicted in FIG. 40 collected with Cu Kα radiation.

FIG. 42 depicts observed peaks for the XRPD pattern depicted in FIG. 40 collected with Cu Kα radiation.

FIG. 43 depicts an XRPD pattern of Crystalline Form C.

FIG. 44 depicts an indexing result for the XRPD pattern depicted in FIG. 43 collected with Cu Kα radiation.

FIG. 45 depicts observed peaks for the XRPD pattern depicted in FIG. 43 collected with Cu Kα radiation.

FIG. 46 depicts proposed energy-temperature plots for Crystalline Forms A, B, and C.

FIG. 47 depicts an XRPD pattern of Crystalline Form A.

FIG. 48 depicts an XRPD pattern of Crystalline Form B.

FIG. 49 depicts an XRPD pattern of a mixture of Crystalline Form A and a minor quantity of Crystalline Form B.

FIG. 50 depicts XRPD patterns of Crystalline Form A before and after DVS analysis (top: before, bottom: after).

FIGS. 51-54 depict XRPD patterns of disordered Crystalline Form A.

FIG. 55 depicts a DSC Thermogram of Crystalline Form B.

FIG. 56 depicts an XRPD pattern of a mixture of Crystalline Forms A and B.

DETAILED DESCRIPTION OF THE INVENTION

As used herein, the term “the Compound” refers to (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane, also known as (+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane. The term “the Compound in hydrochloric acid addition salt form” refers to (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride or (+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride having the following structure:

This compound is free or substantially free of the corresponding (−)-enantiomer, e.g., containing no more than 20% w/w (weight/weight) of the corresponding (−) enantiomer, in free or pharmaceutically acceptable salt form, e.g., no more than 10% w/w of the corresponding (−) enantiomer, in free or pharmaceutically acceptable salt form, e.g., no more than 5% w/w of the corresponding (−) enantiomer, in free or pharmaceutically acceptable salt form, e.g., no more than 2% w/w of the corresponding (−) enantiomer, in free or pharmaceutically acceptable salt form, e.g., no more than 1% w/w of the corresponding (−) enantiomer, in free or pharmaceutically acceptable salt form.

“Crystalline Form A” refers to a crystalline form of the Compound in hydrochloric acid addition salt form as described in any of formulae 1.1-1.77 or as characterized in relevant sections of the Examples below.

“Crystalline Form B” refers to a crystalline form of the Compound in hydrochloric acid addition salt form as described in any of formulae 1.78-1.162 or as characterized in relevant sections of the Examples below.

“Crystalline Form C” refers to a crystalline form of the Compound in hydrochloric acid addition salt form as described in any of formulae 1.163-1.231 or as characterized in relevant sections of the Examples below.

“Crystalline Form D” refers to a crystalline form as described in any of formulae 2.1-2.8 or as characterized in relevant sections of the Examples below.

“Crystalline Form E” refers to a crystalline form as described in any of formulae 2.9-2.16 or as characterized in relevant sections of the Examples below.

“Crystalline Form F” refers to a crystalline form as described in any of formulae 2.17-2.24 or as characterized in relevant sections of the Examples below.

The invention claims Crystalline Form A through F and combinations thereof as described herein, for example in any of formulae 1.1-1.239 or in any of formulae 2.1-2.30. These Crystalline Forms can be made and characterized as set forth in the Example section below. Therefore, the invention provides any of Crystalline Form A through F as set forth in any of formulae 1.1-1.239 or in any of formulae 2.1-2.30 or as characterized in the Example section below.

The term “substantially free” of other crystalline forms refer to less than 10 wt. %, in some embodiments less than 5 wt. %, in some embodiments less than 2 wt. %, still in some embodiments less than 1 wt. %, still in some embodiments less than 0.1 wt. %, yet in some embodiments less than 0.01 wt. % of other forms or other crystal forms, e.g., amorphous or other crystal forms.

The term “solvate” refers to crystalline solid adducts containing either stoichiometric or nonstoichiometric amounts of a solvent incorporated within the crystal structure. Therefore, the term “non-solvate” form herein refers to crystalline forms that are free or substantially free of solvent molecules within the crystal structures of the invention. Similarly, the term “non-hydrate” form herein refers to salt crystals that are free or substantially free of water molecules within the crystal structures of the invention.

The term “amorphous” form refers to solids of disordered arrangements of molecules and do not possess a distinguishable crystal lattice.

The term “patient” includes human and non-human. In one embodiment, the patient is a human. In another embodiment, the patient is a non-human.

The term “anti-solvent” means a solvent in which the Compound and/or the Compound in hydrochloric acid addition salt form ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride) has low solubility or is insoluble. For instance, an anti-solvent includes a solvent in which the Compound and/or the Compound in hydrochloric acid addition salt form has a solubility of less than 35 mg/ml, e.g., a solubility of 10-30 mg/ml, e.g., a solubility of 1-10 mg/ml, e.g., a solubility of less than 1 mg/ml.

The term “XRPD” means X-ray powder diffraction.

It is to be understood that an X-ray powder diffraction pattern of a given sample may vary (standard deviation) depending on the instrument used, the time and temperature of the sample when measured, and standard experimental errors. Therefore, the 2-theta values, d-spacing values, heights and relative intensity of the peaks will have an acceptable level of deviation. For example, the values may have an acceptable deviation of e.g., about 20%, 15%, 10%, 5%, 3%, 2% or 1%. In a particular embodiment, the 2-theta values (°) or the d-spacing values (A) of the XRPD pattern of the crystalline forms of the current invention may have an acceptable deviation of ±0.2 degrees and/or ±0.2 Å. Further, the XRPD pattern of the Crystalline Forms of the invention may be identified by the characteristic peaks as recognized by one skilled in the art. For example, the Crystalline Forms of the invention may be identified by, e.g., two characteristic peaks, in some instances, three characteristic peaks, in another instance, five characteristic peaks. Therefore, the term “substantially as” set forth in a particular table or depicted or shown in a particular figure refers to any crystal which has an XRPD having the major or characteristic peaks as set forth in the tables/figures as recognized by one skilled in the art.

It is also to be understood that the differential scanning calorimetry or thermogravimetric analysis thermograms of a given sample may vary (standard deviation) depending on the instrument used, the time and temperature of the sample when measured, and standard experimental errors. The temperature value itself may deviate by ±10° C., preferably ±5° C., preferably ±3° C. of the reference temperature.

Under most circumstances for XRPDs, peaks within the range of up to about 30° 20 are selected. Rounding algorithms are used to round each peak to the nearest 0.1° or 0.01° 20, depending upon the instrument used to collect the data and/or the inherent peak resolution. Peak position variabilities are given to within ±0.2° 2θ.

The wavelength used to calculate d-spacings (Å) values herein is 1.5405929 Å, the Cu—K_(α1) wavelength (Phys. Rev., A56 (6), 4554-4568 (1997)).

Per USP guidelines, variable hydrates and solvates may display peak variances greater than ±0.2° 2θ.

“Prominent peaks” are a subset of the entire observed peak list and are selected from observed peaks by identifying preferably non-overlapping, low-angle peaks, with strong intensity.

If multiple diffraction patterns are available, then assessments of particle statistics (PS) and/or preferred orientation (PO) are possible. Reproducibility among XRPD patterns from multiple samples analyzed on a single diffractometer indicates that the particle statistics are adequate. Consistency of relative intensity among XRPD patterns from multiple diffractometers indicates good orientation statistics. Alternatively, the observed XRPD pattern may be compared with a calculated XRPD pattern based upon a single crystal structure, if available. Two-dimensional scattering patterns using area detectors can also be used to evaluate PS/PO. If the effects of both PS and PO are determined to be negligible, then the XRPD pattern is representative of the powder average intensity for the sample and prominent peaks may be identified as “representative peaks.” In general, the more data collected to determine representative peaks, the more confident one can be of the classification of those peaks.

“Characteristic peaks,” to the extent they exist, are a subset of representative peaks and are used to differentiate one crystalline polymorph from another crystalline polymorph (polymorphs being crystalline forms having the same chemical composition). Characteristic peaks are determined by evaluating which representative peaks, if any, are present in one crystalline polymorph of a compound against all other known crystalline polymorphs of that compound to within ±0.2° 2θ. Not all crystalline polymorphs of a compound necessarily have at least one characteristic peak.

It has been observed that in reactions to make Crystalline Form A, Crystalline Form B may also form. However, synthesis of products may be controlled by, for example, seeding with Crystalline Form A.

The Crystalline Form A through F, e.g., formulae 1.1-1.239, e.g., formulae 2.1-2.30, and combinations thereof as described herein are useful as an unbalanced triple reuptake inhibitor (TRI), most potent towards norepinephrine reuptake (NE), one-sixth as potent towards dopamine reuptake (DA) and one-fourteenth as much towards serotonin reuptake (5-HT). Therefore, the Crystalline Form A through F, e.g., formulae 1.1-1.239, e.g., formulae 2.1-2.30, and combinations thereof as described herein are useful for the prophylaxis or treatment of a disorder and/or alleviation of associated symptoms of any disorder treatable by inhibiting reuptake of multiple biogenic amines causally linked to the targeted CNS disorder, wherein the biogenic amines targeted for reuptake inhibition are selected from norepinephrine, and/or serotonin, and/or dopamine. Therefore, the invention provides a method for the prophylaxis or treatment of any of the following disorders:

-   -   attention deficit hyperactivity disorder (ADHD) and related         behavioral disorders, as well as forms and symptoms of substance         abuse (alcohol abuse, drug abuse), obsessive compulsive         behaviors, learning disorders, reading problems, gambling         addiction, manic symptoms, phobias, panic attacks, oppositional         defiant behavior, conduct disorder, academic problems in school,         smoking, abnormal sexual behaviors, schizoid behaviors,         somatization, depression, sleep disorders, generalized anxiety,         stuttering, and tic disorders. Further disorders are disclosed         in U.S. Publication No. 2007/0082940, the contents of which are         hereby incorporated by reference in their entirety;     -   depression, anxiety disorders, autism, traumatic brain injury,         cognitive impairment, and schizophrenia (particularly for         cognition), obesity, chronic pain disorders, personality         disorder, and mild cognitive impairment;     -   panic disorder, posttraumatic stress disorder, obsessive         compulsive disorder, schizophrenia and allied disorders,         obesity, tic disorders, Parkinson's disease;     -   disorders disclosed in WO 2013/019271, the contents of which are         hereby incorporated by reference in their entirety;     -   fragile X-associated disorder;     -   fragile X-associated disorder wherein the patient was refractory         to a prior course of treatment for the fragile X-associated         disorder;     -   attention-deficit/hyperactivity disorder (ADHD) wherein the ADHD         is co-morbid with one or both of anxiety and depression (e.g.,         depression), e.g., in a patient with a fragile X-associated         disorder;     -   autism spectrum disorder (ASD);     -   disorders disclosed in International Application No.         PCT/US2014/069401, the contents of which are hereby incorporated         by reference in their entirety,         comprising administering to a patient in need thereof a         therapeutically effective amount of any of Crystalline Form A         through F according to any of formulae 1.1-1.239, e.g.,         Crystalline Form A, e.g., any of formulae 1.1-1.77, e.g.,         Crystalline Form B, e.g., any of formulae 1.78-1.162, e.g., any         of formulae 2.1-2.30.

Disorders contemplated for treatment employing the Crystalline Forms of the invention as described herein include disorders in the Quick Reference to the Diagnostic Criteria From DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), The American Psychiatric Association, Washington, D.C., 1994. These target disorders, include, but are not limited to, Attention-Deficit/Hyperactivity Disorder, Predominately Inattentive Type; Attention-Deficit/Hyperactivity Disorder, Predominately Hyperactivity-Impulsive Type; Attention-Deficit/Hyperactivity Disorder, Combined Type; Attention-Deficit/Hyperactivity Disorder not otherwise specified (NOS); Conduct Disorder; Oppositional Defiant Disorder; and Disruptive Behavior Disorder not otherwise specified (NOS).

Depressive disorders amenable for treatment and/or prevention according to the invention include, but are not limited to, Major Depressive Disorder, Recurrent; Dysthymic Disorder; Depressive Disorder not otherwise specified (NOS); and Major Depressive Disorder, Single Episode.

Addictive disorders amenable for treatment and/or prevention employing the methods and compositions of the invention include, but are not limited to, eating disorders, impulse control disorders, alcohol-related disorders, nicotine-related disorders, amphetamine-related disorders, cannabis-related disorders, cocaine-related disorders, hallucinogen use disorders, inhalant-related disorders, and opioid-related disorders.

Preferably, the Crystalline Form of the invention is Crystalline Form A.

As used herein, “therapeutically effective amount” refers to an amount effective, when administered to a human or non-human patient, to provide a therapeutic benefit such as amelioration of symptoms. The specific dose of substance administered to obtain a therapeutic benefit will, of course, be determined by the particular circumstances surrounding the case, including, for example, the specific substance administered, the route of administration, the condition being treated, and the individual being treated.

A dose or method of administration of the dose of the present disclosure is not particularly limited. Dosages employed in practicing the present disclosure will of course vary depending, e.g. on the mode of administration and the therapy desired. In general, satisfactory results, are indicated to be obtained on oral administration at dosages of the order from about 0.01 to 2.0 mg/kg. An indicated daily dosage for oral administration may be in the range of from about 0.75 mg to 200 mg, conveniently administered once, or in divided doses 2 to 4 times, daily or in sustained release form. Unit dosage forms for oral administration thus for example may comprise from about 0.2 mg to 75 mg or 150 mg, e.g. from about 0.2 mg or 2.0 mg or 50 mg or 75 mg or 100 mg to 200 mg or 500 mg of any of Crystalline Forms A through F or combinations thereof, preferably Crystalline Form A, e.g., any of formulae 1.1-1.77, together with a pharmaceutically acceptable diluent or carrier therefor.

The Crystalline Forms of the invention may be administered by any suitable route, including orally, parenterally, transdermally, or by inhalation, including by sustained release, although various other known delivery routes, devices and methods can likewise be employed. In some embodiments, provided is a sustained release pharmaceutical composition, e.g., an oral sustained release pharmaceutical composition, comprising any of the Crystalline Forms of the invention, e.g., Crystalline Form A, e.g., any of formulae 1.1-1.77, over a sustained delivery period of approximately 6 hours or longer, e.g., 8 hours or longer, e.g., 12 hours or longer, e.g., 18 hours or longer, e.g., 24 hours or longer. In some embodiments, provided is an immediate release pharmaceutical composition, e.g., an oral immediate release pharmaceutical composition, comprising any of the Crystalline Forms of the invention, e.g., Crystalline Form A, e.g., any of formulae 1.1-1.77.

Further dosage and formulation are provided in International Application No. PCT/US2014/069401 and International Application No. PCT/US2014/069416, the contents of each of which are hereby incorporated by reference in their entirety.

(1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in hydrochloric acid addition salt form may be prepared as described in U.S. Patent Publication No. 2007/0082940 or International Publication No. WO 2013/019271, both of which are incorporated herein by reference in their entirety.

While both U.S. Patent Publication No. 2007/0082940 and International Publication No. WO 2013/019271 describe synthesis of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride, neither discuss any particular crystal form of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride.

The following section illustrates methods of making and characterizing Crystalline Forms A through F of the invention. Both thermodynamic and kinetic crystallization techniques are employed. These techniques are described in more detail below.

Antisolvent Precipitation: Solutions are prepared in various solvents and filtered through a 0.2-μm nylon filter into a vial. Antisolvent is then added until precipitation is observed. The resulting solids are isolated by vacuum filtration and analyzed.

Crash Cool (CC): Solutions are prepared in various solvents at an elevated temperature and filtered warm through a 0.2-μm nylon filter into a pre-cooled vial. The vial is placed in a (dry ice+isopropanol) cooling bath. Samples are placed into a freezer if no solids are observed to immediately precipitate. The resulting solids are isolated by vacuum filtration and analyzed.

Fast Evaporation (FE): Solutions are prepared in various solvents and sonicated between aliquot additions to assist in dissolution. Once a mixture reaches complete dissolution, as judged by visual observation, the solution is filtered through a 0.2-μm nylon filter. The filtered solution is allowed to evaporate at ambient conditions in an uncapped vial. Solutions are evaporated to dryness unless designated as partial evaporations. The solids that formed are isolated and analyzed.

Freeze-Drying (Lyophilization): Solutions are prepared in 1:1 dioxane: water or water, filtered through a 0.2-μm nylon filter, and frozen in a vial or flask immersed in a bath of dry ice and isopropanol. The vial or flask containing the frozen sample is attached to a Flexi-Dry lyophilizer and dried for a measured time period. After drying, the solids are isolated and stored in the freezer over desiccant until use.

Milling: A solid sample is placed into a stainless steel grinding jar with a grinding ball. The sample is then ground at 30 Hz on a ball mill (Retsch Mixer Mill model MM200) for a set amount of time. The solids are collected and analyzed.

Relative Humidity Stress: Solids are stored at approximately 40° C./75% RH condition for a measured time period by placing the solids into a vial inside a sealed temperature/humidity chamber at the controlled condition. Samples are analyzed after removal from the stress environment.

Rotary Evaporation: Solutions of the Compound in hydrochloric acid addition salt form ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride) in HFIPA are prepared. Solids are obtained by rotary evaporation of the solvent under vacuum, with the sample vial immersed in a heated water bath at approximately 40° C. Solids are then dried for an additional approximate 10 minutes under vacuum at ambient temperature. After evaporation, the solids are stored in the freezer over desiccant until use.

Slow Cooling (SC): Solutions are prepared in various solvents at an elevated temperature. The solutions are filtered warm through a 0.2-μm nylon filter into a warm vial. The vial is capped and left on the hot plate, and the hot plate is turned off to allow the sample to cool slowly to ambient temperature. If no solids are present after cooling to ambient temperature, the sample is placed in a refrigerator and/or freezer for further cooling. Solids are collected by vacuum filtration and analyzed.

Slow Evaporation (SE): Solutions are prepared in various solvents and sonicated to assist in dissolution. Once a mixture reaches complete dissolution, as judged by visual observation, the solution is filtered through a 0.2-μm nylon filter. The filtered solution is allowed to evaporate at ambient conditions in a vial covered with aluminum foil perforated with pinholes. Solutions are evaporated to dryness unless designated as partial evaporations. The solids that form are isolated and analyzed.

Slurry Experiments: Suspensions are prepared by adding enough solids to a given solvent so that excess solids are present. The mixture is then agitated in a sealed vial at ambient temperature or an elevated temperature. After a given period of time, the solids are isolated by vacuum filtration and analyzed.

Vapor Diffusion (VD): Solutions are prepared in various solvents and filtered through a 0.2-μm nylon filter. The filtered solution is dispensed into a 1-dram vial, which is then placed inside a 20-mL vial containing antisolvent. The 1-dram vial is left uncapped and the 20-mL vial is capped to allow vapor diffusion to occur. The resulting solids are isolated and analyzed.

Vapor Stress (VS): A solid sample is placed into a 1-dram vial. The 1-dram vial is then placed into a 20-mL vial containing solvent. The 20-mL vial is capped and left at ambient conditions for a measured time period. Samples are analyzed after removal from the stress environment.

XRPD Overlays: The overlays of XRPD patterns are generated using Pattern Match 2.3.6.

XRPD Indexing: The high-resolution XRPD patterns of Crystalline Forms of the invention are indexed using X'Pert High Score Plus (X'Pert High Score Plus 2.2a (2.2.1)) or proprietary software. Indexing and structure refinement are computational studies.

Instrumental Techniques: The test materials in this study are analyzed using the instrumental techniques described below.

Differential Scanning Calorimetry (DSC): DSC is performed using a TA Instruments differential scanning calorimeter. Temperature calibration is performed using NIST traceable indium metal. The sample is placed into an aluminum DSC pan, covered with a lid, and the weight is accurately recorded. A weighed aluminum pan configured as the sample pan is placed on the reference side of the cell. The data acquisition parameters and pan configuration are displayed in the image of each thermogram. The method code on the thermogram is an abbreviation for the start and end temperature as well as the heating rate; e.g., −30-250-10 means “from −30° C. to 250° C., at 10° C./min”. The following table summarizes the abbreviations used in each image for pan configurations:

Abbreviation Meaning T0C Tzero crimped pan HS Lid hermetically sealed HSLP Lid hermetically sealed and perforated with a laser pinhole C Lid crimped NC Lid not crimped

Thermogravimetric Analysis (TGA): TG analyses are performed using a TA Instruments thermogravimetric analyzer. Temperature calibration is performed using nickel and Alumel™. Each sample is placed in an aluminum pan. The sample is hermetically sealed, the lid pierced, then inserted into the TG furnace. The furnace is heated under nitrogen. The data acquisition parameters are displayed in the image of each thermogram. The method code on the thermogram is an abbreviation for the start and end temperature as well as the heating rate; e.g., 25-350-10 means “from 25° C. to 350° C., at 10° C./min”.

X-ray Powder Diffraction (XRPD): Inel XRG-300. X-ray powder diffraction analyses are performed on an Inel XRG-3000 diffractometer, equipped with a curved position-sensitive detector with a 2θ range of 120°. Real time data is collected using Cu Kα radiation at a resolution of 0.03° 2θ. The tube voltage and amperage are set to 40 kV and 30 mA, respectively. Patterns are displayed from 2.5 to 40° 2θ to facilitate direct pattern comparisons. Samples are prepared for analysis by packing them into thin-walled glass capillaries. Each capillary is mounted onto a goniometer head that is motorized to permit spinning of the capillary during data acquisition. Instrument calibration is performed daily using a silicon reference standard. The data acquisition and processing parameters are displayed on each pattern found in the data section.

X-ray Powder Diffraction (XRPD): Bruker D-8 Discover Diffractometer. XRPD patterns are collected with a Bruker D-8 Discover diffractometer and Bruker's General Area Diffraction Detection System (GADDS, v. 4.1.20). An incident beam of Cu Kα radiation is produced using a fine-focus tube (40 kV, 40 mA), a Göbel mirror, and a 0.5 mm double-pinhole collimator. The sample is packed between 3-micron thick films to form a portable disc-shaped specimen. The prepared specimen is loaded in a holder secured to a translation stage and analyzed in transmission geometry. The incident beam is scanned and rastered to optimize orientation statistics. A beam-stop is used to minimize air scatter from the incident beam at low angles. Diffraction patterns are collected using a Hi-Star area detector located 15 cm from the sample and processed using GADDS. Prior to the analysis a silicon standard is analyzed to verify the Si 111 peak position. The data acquisition and processing parameters are displayed on each pattern found in the data section.

X-ray Powder Diffraction (XRPD): PANalytical X'Pert Pro Diffractometer. XRPD patterns are collected using a PANalytical X'Pert Pro diffractometer. The specimen is analyzed using Cu radiation produced using an Optix long fine-focus source. An elliptically graded multilayer mirror is used to focus the Cu Kα X-rays of the source through the specimen and onto the detector. The specimen is sandwiched between 3-micron thick films, analyzed in transmission geometry, and rotated parallel to the diffraction vector to optimize orientation statistics. A beam-stop, short antiscatter extension, antiscatter knife edge, and helium purge are used to minimize the background generated by air scattering. Soller slits are used for the incident and diffracted beams to minimize axial divergence. Diffraction patterns are collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen. The data-acquisition parameters of each diffraction pattern are displayed above the image of each pattern in the data section. Prior to the analysis, a silicon specimen (NIST standard reference material 640d) is analyzed to verify the position of the silicon 111 peak.

For indexing, agreement between the allowed peak positions, marked with bars, and the observed peaks indicates a consistent unit cell determination. Successful indexing of the pattern indicates that the sample is composed primarily of a single crystalline phase. Space groups consistent with the assigned extinction symbol, unit cell parameters, and derived quantities are tabulated below the figure. To confirm the tentative indexing solution, the molecular packing motifs within the crystallographic unit cells must be determined. No attempts at molecular packing are performed.

Abbreviations

-   acetonitrile (ACN) -   birefringence (B) -   brine (saturated aqueous solution of sodium chloride) -   density (d) -   dichloromethane (DCM) -   equivalents (eq) -   ethanol (EtOH) -   ethyl acetate (EtOAc) -   extinction (E) -   formula weight (FW) -   gram (g) -   hour or hours (h, hrs) -   hexafluoroisopropanol (HFIPA) -   high performance (pressure) liquid chromatography (HPLC) -   isopropanol (IPA) -   isopropyl acetate (IPAc) -   isopropyl ether (IPE) -   kilogram (kg) -   liters (L) -   methanol (MeOH) -   methyl ethyl ketone (MEK) -   minute(s) (min) -   millilitres (mL) -   molarity of a solution (mol/L) (M) -   molecular weight (MW) -   moles (mol) -   room temperature (RT) -   saturated (sat) -   sodium hexamethyldisilylazane (NaHMDS) -   starting material (SM) -   tetrahydrofuran (THF) -   2,2,2,-trifluoroethanol (TFE) -   versus (vs) -   weight (wt)

Example 1—Preparation of Crystalline Form A

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction 2-naphthylacetonitrile 167.21 NA 1.0 mol eq (SM) 1500 g/8.97 mol (S)-(+)-epichlorohydrin  92.52 3.12  1.30 mol eq  1081 g/11.67 mol tetrahydrofuran  72.11 0.889 6.0 ml/g SM 9.0 L 2M sodium bis(trimethylsilyl)amide  2.0M 0.916 2 mol eq  9.0 L/18.6 mol in THF 2M sodium bis(trimethylsilyl)amide  2.0M 0.916 0.067 mol eq  0.30 L/0.60 mol in THF borane-dimethylsulfide 10.0M 0.80  2.5 mol eq 2.25 L borane-dimethylsulfide 10.0M 0.80  0.39 mol eq 0.35 L Isolation 2M HCl (aqueous)   2M NA 11.5 mL/g SM 17.3 L isopropyl acetate 102.13 0.872 4 mL/g SM 6.0 L water  18.02 1.00  5 mL/g SM 7.5 L ammonia (aqueous) NA 0.889 1.5 mL/g SM 2.25 L isopropyl acetate 102.13 0.872 5 mL/g SM 7.5 L isopropyl acetate 102.13 0.872 5 mL/g SM 7.5 L 5% aqueous dibasic sodium phosphate NA NA 4 mL/g SM 6.0 L brine saturated NA NA 4 mL/g SM 6.0 L isopropyl acetate 102.13 0.872 10 mL/g SM 15 L para-toluenesulfonic acid- 190.22 NA 0.93 mol eq 1586 g/8.34 mol monohydrate isopropyl acetate 102.13 0.872 2 mL/g SM 3.0 L isopropyl acetate 102.13 0.872 2 mL/g SM 3.0 L

Charge 2-naphthylacetonitrile (1500 g, 8.97 mol, SM) to a 3-neck, 50 L round bottom flask equipped with an overhead stirrer, addition funnel, thermocouple, cooling bath, nitrogen inlet and drying tube. Charge tetrahydrofuran (6.0 L, 4 mL/g, SM) to the reaction vessel. Stir at room temperature until all of the 2-naphthylacetonitrile is dissolved. Charge (S)-(+)-epichlorohydrin (1081 g, 11.67 mol, 1.30 eq) to the reaction vessel. Cool the reaction mixture to an internal temperature of −28° C. Use dry ice/acetone bath to cool. Dry ice added to bath intermittently to keep cooling bath between −35 and −25° C. during sodium bis(trimethylsilyl)amide addition. Charge a solution of sodium bis(trimethylsilyl)amide in THF (9.0 L, 18.0 mol, 2 mol eq) to the addition funnel and slowly add to the chilled reaction mixture at a rate such that the internal temperature remains at less than −14° C. Addition requires 1 hr 40 minutes. During the addition the internal temperature is generally between −20 and −17° C. After completion of the addition, the resulting solution is stirred at between −21 and −16° C. for 2 hours 30 minutes. Monitor the reaction by HPLC. Maintain −20 to −15° C. temperature of the reaction mixture while analyzing sample by HPLC.

HPLC assay at 2 hr 30 minutes shows reaction is not complete. Add additional sodium bis(trimethylsilyl)amide in THF (0.30 L, 0.60 mol, 0.067 mole eq) over 10 minutes via addition funnel, keeping the internal temperature of the reaction mixture less than −15° C. Stir 15 minutes at which point HPLC assay shows reaction is complete. Charge borane-dimethylsulfide (2.25 L, 22.5 mol, 2.5 mole eq) complex via addition funnel at a rate such that the internal temperature of the reaction mixture remains below 0° C. Addition requires 40 minutes. After completion of the borane addition slowly heat the reaction mixture to 40° C. Once an internal temperature of 40° C. is obtained discontinue heating. A slow steady exotherm over approximately two hours is observed which results in a maximum internal temperature of 49° C. Upon completion of the exotherm increase the internal temperature to 60° C. Stir reaction mixture overnight at 60° C. Monitor the reaction by HPLC. Maintain 60° C. temperature of the reaction mixture while analyzing sample by HPLC.

Charge additional borane-dimethylsulfide (0.35 L, 0.70 mol, 0.39 mole eq) to reaction mixture via addition funnel. Stir the reaction mixture 3 hours 30 minutes at 60° C. Cool reaction mixture to room temperature.

To a second 3-neck, 50 L round bottom flask equipped with an overhead stirrer, thermocouple, cooling bath, and nitrogen inlet charge 2M HCl in water (17.3 L, 11.5 mL/g SM, prepared from 2.9 L concentrated HCl and 14.4 L water). Cool HCl/water solution to 3° C. Slowly transfer room temperature reaction mixture containing the cyclopropyl amine to the chilled HCl solution at a rate such that the maximum internal temperature of the quench mixture is 23° C. Quench requires 2 hr 50 minutes. When the reaction quench is complete, heat the two phase mixture to 50° C. Stir for one hour at 50° C. Cool to room temperature. Add isopropylacetate (6.0 L, 4 mL/g SM). Add water (7.5 L, 5 mL/g SM). Agitate mixture for a minimum of 15 minutes. Discontinue agitation and allow layers to settle for a minimum of 30 minutes. Discard the organic (upper) layer. Add aqueous ammonia (2.25 L, 1.5 mL/g SM) to the aqueous layer. Add isopropylacetate (7.5 L, 5 mL/g). Agitate mixture for a minimum of 15 minutes. Discontinue agitation and allow layers to settle for a minimum of 30 minutes. Separate layers. Product is in the organic (upper) layer. Add isopropylacetate (7.5 L, 5 mL/g SM) to aqueous layer. Agitate mixture for a minimum of 15 minutes. Discontinue agitation and allow layers to settle for a minimum of 30 minutes. Separate layers. Product is in the organic (upper) layer. Combine the two isopropylacetate extracts. Add 5% dibasic sodium phosphate in water (6.0 L, 4 mL/g SM) to combined extracts. Agitate mixture for a minimum of 15 minutes. Discontinue agitation and allow layers to settle for a minimum of 30 minutes. Separate layers and discard aqueous (lower) layer. Add saturated brine (6.0 L, 4 mL/g SM) to combined extracts. Agitate mixture for a minimum of 15 minutes. Discontinue agitation and allow layers to settle for a minimum of 30 minutes. Separate layers and discard aqueous (lower) layer. Concentrate the final organic layer in a tared 20 L Buchi flask in vacuo. Obtain a total of 1967.6 g of a light orange waxy solid. Transfer solids to a 50 L 3-neck round bottom flask equipped with an overhead stirrer, thermocouple, heating mantel, nitrogen inlet and drying tube. Add isopropyl acetate (15 L, 10 mL/g SM). Heat the mixture to 50° C. Add p-toluene sulfonic acid monohydrate (1586 g, 8.34 mol, 0.93 mole eq) in portions over 30 minutes keeping the temperature less than 60° C. Upon completion of the addition discontinue heating and allow the mixture to cool to room temperature. Collect the solids by filtration. Wash the filtercake with isopropyl acetate (3 L, 2 mL/g SM). Wash the filtercake a second time with isopropyl acetate (3 L, 2 mL/g SM). Dry filtercake to a constant weight in the filter funnel by pulling air through the cake using vacuum. After an initial drying period the filtercake is broken up with a spatula and the cake agitated at intervals to promote drying. Obtain 2049 g of a white solid. HPLC assay: 98.2% for the main peak and a cis:trans ratio of 98.5:1.5.

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction naphthylcyclopropylamine-tosylate 399.51 NA 1.0 mole eq 2037.9 g/5.10 mol  salt isopropyl acetate 102.13 0.872 6.5 mL/g SM 13.2 L thionyl chloride 118.97 1.638 1.2 eq 445 mL/6.13 mol 5M NaOH 5.0M NA 6.0 mol eq  6.1 L/30.5 mol Isolation 1M NaOH 1.0M NA 1 mL/g SM 2.1 L isopropyl acetate (back extraction) 102.13 0.872 3.75 mL/g SM 7.6 L saturated brine NA NA 2 mL/g SM 4.1 L magnesium sulfate NA NA NA NA isopropylacetate (wash) 102.13 0.872 0.5 mL/g SM 1.0 L isopropylacetate (dilution) 102.13 0.872 3.5 mL/g SM 7.2 L hydrogen chloride in isopropyl 5.7M NA 1.0 eq 0.90 L alcohol isopropylacetate (wash) 102.13 0.872 1.13 mL/g SM 2.3 L isopropylacetate (wash) 102.13 0.872 1.13 mL/g SM 2.3 L isopropyl alcohol 60.1 0.786 7.45 mL/g SM 34.6 L isopropyl alcohol 60.1 0.786 1.5 mL/g SM 6.9 L isopropyl alcohol 60.1 0.786 1.5 mL/g SM 6.9 L Note: Addition of 5M NaOH to the reaction mixture is exothermic and requires active cooling.

Charge 2039.7 g (5.10 mol, 1.0 mol eq) of the naphthylcyclopropylamine-tosylate salt obtained above to a 50 L 3-neck round bottom flask equipped with an overhead stirrer, thermocouple, addition funnel, nitrogen inlet, drying tube and room temperature water bath. Charge 13.2 L of isopropyl acetate (IPAc, 13.2 L, 6.5 mL/g SM) to the reaction flask and stir at room temperature to give an white slurry. Add 445 mL of thionyl chloride (6.13 mol, 1.2 mol eq) via the addition funnel keeping the temperature less than 25° C. Addition requires 1 hr 5 minutes. Stir the thick slurry at ambient temperature for a minimum of two hours. Monitor the reaction by HPLC. Maintain the reaction mixture at ambient temperature while analyzing sample by HPLC. Add 5M NaOH (6.1 L, 30.5 mol, 6.0 mol eq) via addition funnel using an ice/water bath to keep less than 30° C. Addition requires 1 hr 40 min. Monitor the reaction by HPLC. Maintain the reaction mixture at ambient temperature while analyzing sample by HPLC. Stir reaction mixture at 25° C. for 1 hr 5 min then allow layers to settle. Separate the layers. Wash the organic (upper) layer with 1M NaOH (2.1 L, 1 mL/g SM). Combine the two aqueous layers. Back extract the combined aqueous layers with isopropylacetate (7.6 L, 3.75 mL/g SM). Combine the washed organic layer and the back extract. Wash the combined organic layers with saturated brine (4.1 L, 2 mL/g SM). Dry organic layers over granular magnesium sulfate. Filter to remove solids. Wash filtercake with isopropylacetate (1 L, 0.5 mL/g SM). Concentrate combined filtrate and wash in a 20 L Buchi Rotavap flask to a total volume of 4.2 L. Transfer to a 22 L 3-neck round bottom flask equipped with overhead stirrer, addition funnel, thermocouple, cooling bath, nitrogen inlet, and drying tube. Dilute with isopropylacetate (7.2 L, total volume of solution=11.4 L, 5.6 mL/g SM). Add hydrogen chloride in isopropyl alcohol (5.7 M, 0.90 L, 5.13 mol, 1.0 mol eq) via addition funnel over 50 minutes at a rate such that the internal temperature remains below 30° C. Stir the slurry for 45 minutes at room temperature. Filter to collect solids. Wash filtercake with isopropylacetate (2.3 L, 1.13 mL/g SM). Wash filtercake a second time with isopropylacetate (2.3 L, 1.13 mL/g SM). Partially dry filtercake by pulling air through the cake with vacuum. HPLC assay of the wet cake shows 96.3 area percent purity and an EE of 89.5%.

Combine wet cakes from this experiment and from another batch in a 50 L 3-neck round bottom flask equipped with overhead stirrer, heating mantel, thermocouple, reflux condenser, nitrogen inlet, and drying tube. Add isopropyl alcohol (34.6 L, 7.45 mL/g SM). Heat the slurry to reflux. Maintain reflux for three hours. Discontinue heating and allow to cool to room temperature. Filter to collect solids. Wash filtercake with isopropyl alcohol (6.9 L, 1.5 mL/g SM). Wash filtercake a second time with isopropyl alcohol (6.9 L, 1.5 mL/g SM). Dry filtercake to a constant weight by pulling air through the cake using vacuum. Obtain 2009 g of product as a tan solid. HPLC: >99.5%. Chiral HPLC: 95.4%.

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction (1R,5S)-1-(naphthalen-2-yl)-3- 245.74 NA 1.0 2009 g azabicyclo[3.1.0]hexane hydrochloride ethanol (special industrial) 46.07 0.789 10.7 mL/g 21.5 L Isolation ethanol (SI), wash 46.07 0.789 2.14 mL/g 4.3 L Note: Minimal amount of ethanol necessary to completely dissolve the starting material should be used.

Charge (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride to a 50 L 3-neck round bottom flask equipped with an overhead stirrer, thermocouple, reflux condenser, heating mantel, nitrogen inlet and drying tube. Add ethanol (20 L, mL/g SM). Heat the stirred slurry to 77° C. Add additional ethanol in 0.5 L aliquots and return mixture to reflux until all solids dissolve. Complete dissolution after the addition of 1.5 L additional ethanol, 21.5 L total. Discontinue heating and allow solution to cool to room temperature. Filter to collect solids. Wash filtercake with ethanol (4.3 L, 2.14 mL/g SM). Dry filtercake to a constant weight by pulling air through the filtercake using vacuum. Obtain 1435 g of light tan solids. Yield=74%. HPLC: 99.5%. Chiral HPLC: 99.9%.

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction (1R,5S)-1-(naphthalen-2-yl)-3- 245.74 NA 1.0 mol eq 1406 g/5.72 mol azabicyclo[3.1.0]hexane hydrochloride (SM) water 18.02 1.0  10 mL/g SM 14.0 tetrahydrofuran 72.11 0.889 2 mL/g SM 2.8 L isopropylacetate 102.13 0.872 2 mL/g SM 2.8 L Isolation ammonia (aqueous) 15.0M  0.90  3.0 mol eq  1.14 L/17.1 mol isopropyl acetate 102.13 0.872 10 mL/g SM 14.0 L magnesium sulfate NA NA NA NA isopropyl acetate (wash) 102.13 0.872 1.42 mL/g SM 2.0 L isopropyl alcohol 60.1 0.786 10 mL/g SM 14.0 L hydrogen chloride in isopropyl 5.7M NA 0.84 mol eq 845 mL alcohol hydrogen chloride in isopropyl 5.6M NA 0.11 mol eq 110 mL alcohol hydrogen chloride in isopropyl 5.6M NA 0.06 mol eq 60 mL alcohol isopropyl alcohol (wash one) 60.1 0.786 2.0 mL/g SM 2.8 L isopropyl alcohol (wash two) 60.1 0.786 2.0 mL/g SM 2.8 L

Charge the Compound in hydrochloric acid addition salt form ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride) (1406 g, 5.72 mol, 1.0 mol eq) (the compound obtained from the step above and another batch) to a 22 L, 3-neck round bottom flask equipped with an overhead stirrer, heating mantel, thermocouple, and nitrogen inlet. Add water (14 L, 10 mL/g SM). Heat the slurry to an internal temperature of 34° C. to dissolve all solids. Transfer to a large separatory funnel. Add tetrahydrofuran (2.8 L, 2 mL/g SM). Add isopropylacetate (2.8 L, 2 mL/g SM). Discontinue stirring and allow layers to separate. Discard the organic (upper) layer. Product is in the lower (aqueous) layer. To the aqueous (lower) layer add aqueous ammonia (1.14 L, 17.1 mol, 3.0 mol eq). Add isopropylacetate (14.0 L, 10 mL/g SM). Agitate mixture for a minimum of 15 minutes. Discontinue agitation and allow layers to settle for a minimum of 30 minutes. Separate the layers. Product is in the organic (upper) layer. Add granular magnesium sulfate to the organic layer. Filter to remove solids. Wash the filtercake with isopropylacetate (1 L). Wash the filtercake a second time with isopropylacetate (1 L). Concentrate combined filtrate and washes in a 20 L Buchi rotavap flask to give an off-white solid. Charge solid to a 22 L round bottom flask equipped with overhead stirrer, thermocouple, addition funnel, nitrogen inlet and drying tube. Add isopropyl alcohol (14 L, 10 mL/g SM). Stir at room temperature to dissolve all solids. Charge 5.7 N HCl in IPA (175 mL, 1.0 mol, 0.17 mol eq) via addition funnel over 10 minutes to form white solids. Stir the thin slurry at room temperature for 30 minutes. Charge 5.7 N HCl in IPA (670 mL, 3.82 mol, 0.67 mol eq) followed by 5.6 N HCl in IPA (110 mL, 0.62 mol, 0.11 mol eq) via addition funnel over 55 minutes. Stir the slurry for 35 minutes then assay the mother liquors for loss. Add 5.6 N HCl in IPA (60 mL, 0.34 mol, 0.06 mol eq) over 10 minutes via addition funnel. Stir the slurry for 30 minutes then assay the mother liquors for loss. Filter to collect solids. Wash filtercake with isopropyl alcohol (2.8 L, 2 mL/g SM). Wash filtercake a second time with isopropyl alcohol (2.8 L, 2 mL/g SM). Dry filtercake to a constant weight by pulling air through the filtercake using vacuum. Obtain 1277 g of product as an off-white solid. HPLC: 99.9%.

The resulting compound exhibits a crystalline XRPD pattern (FIG. 1), and is designated as Crystalline Form A. The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640d) is analyzed to verify the Si 111 peak position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short anti-scatter extension, and an anti-scatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. The diffraction pattern is collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. The experimental XRPD pattern is collected according to cGMP specifications. The XRPD pattern collected is shown in FIG. 1 (Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.01-40.00° 2θ, Step Size: 0.017° 2θ, Collection Time: 1939 s, Scan Speed: 1.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission).

Thermal analysis results are shown in FIG. 2 (DSC, Size: 1.7800 mg, Method: (−30)-300-10, TOC; TGA, Size: 6.8320 mg, Method: 00-350-10). By TGA, Crystalline Form A exhibits approximately 0.4% weight loss up to 200° C. The dramatic weight change in the TGA at approximately 276° C. is consistent with decomposition. The DSC thermogram (FIG. 2) displays multiple endotherms between approximately 245 and 248° C. concurrent with the dramatic weight change by TGA, suggesting overlapping events are occurring during heating.

Characterization data for Crystalline Form 1 are summarized in Table 1 below:

TABLE 1 Analysis Result DSC^(a) 247° C. (endo, peak; 245° C. onset); 248° C. (endo, shoulder); 248° C. (endo, peak) TGA^(a) 0.4% weight loss up to 200° C. 276° C. (onset, decomposition) ^(a)Temperatures are rounded to the nearest ° C.; weight loss values are rounded to one decimal place.

Based on the dynamic vapor sorption/desorption data collected (FIG. 3), Crystalline Form A obtained is a non-hygroscopic material. Upon initial equilibration at 5% RH, Crystalline Form A shows a weight loss of 0.03%; a weight gain of 0.10% is observed from 5% to 95% RH. During the desorption step from 95% to 5% RH, Crystalline Form A exhibits approximately 0.10% weight loss.

Post-moisture balance material is similar to starting material by XRPD (FIG. 50).

Data acquisition parameters for dynamic vapor sorption/desorption isotherm:

Notes Range 5% to 95% 25° C. at 10% increments Drying OFF Max Equil Time 180 min Equil Crit 0.0100 wt % in 5.00 min T-RH Steps 25, 5; 25, 15; 25, 25; 25, 35; 25, 45; 25, 55; 25, 65; 25, 75; 25, 85; 25, 95; 25, 85; 25, 75; 25, 65; 25, 55; 25, 45; 25, 35; 25, 25; 25, 15; 25, 5 Data Logging Interval 2.00 min or 0.0100 wt % Step Elap Samp Time Time Weight Weight Temp Samp min min mg % chg deg C. RH % n/a 0.1 11.532 0.000 25.20 1.70 13.1 13.2 11.528 −0.034 25.18 5.06 11.5 24.7 11.529 −0.025 25.19 15.24 13.0 37.7 11.529 −0.024 25.22 24.81 13.0 50.7 11.530 −0.019 25.21 34.82 17.0 67.7 11.530 −0.016 25.21 44.81 25.0 92.7 11.531 −0.012 25.20 54.86 28.3 121.0 11.532 −0.005 25.20 64.82 12.8 133.8 11.533 0.005 25.20 74.66 13.0 146.8 11.535 0.024 25.19 84.55 13.3 160.0 11.540 0.068 25.19 94.54 10.8 170.8 11.536 0.037 25.18 85.08 11.0 181.8 11.534 0.019 25.18 75.28 13.0 194.8 11.532 0.003 25.18 64.96 13.0 207.8 11.531 −0.007 25.18 55.08 13.0 220.8 11.531 −0.013 25.18 45.09 13.0 233.8 11.530 −0.016 25.18 35.13 13.0 246.8 11.530 −0.021 25.17 25.12 21.0 267.8 11.529 −0.025 25.17 15.20 10.0 277.8 11.528 −0.032 25.17 4.95

Example 2—Preparation of Crystals of Form A

Solution of the Compound in hydrochloric acid addition salt form ((1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride) is prepared using 98.5 mg of the Compound from Example 1 in 2 mL methanol and filtered through a 0.2-μm nylon filter. A 0.5 mL aliquot of the filtered solution is dispensed into a 1-dram open vial, which is then placed inside a 20-mL vial containing 3 mL antisolvent ethyl acetate. The 1-dram vial is left uncapped and the 20-mL vial is capped to allow vapor diffusion to occur. Single crystals are grown in the 1-dram vial after approximately 7 days.

Data Collection: A colorless plate of C₁₅H₁₆ClN [Cl, C₁₅H₁₆N] having approximate dimensions of 0.38×0.30×0.18 mm, is mounted on a fiber in random orientation. Preliminary examination and data collection are performed with Mo Kα radiation (2=0.71073 Å) on a Nonius Kappa CCD diffractometer equipped with a graphite crystal, incident beam monochromator. Refinements are performed using SHELX97 (Sheldrick, G. M. Acta Cryst., 2008, A64, 112). Cell constants and an orientation matrix for data collection are obtained from least-squares refinement using the setting angles of 5812 reflections in the range 1°<θ<27°. The refined mosaicity from DENZO/SCALEPACK is 0.38° indicating good crystal quality (Otwinowski, Z.; Minor, W. Methods Enzymol. 1997, 276, 307). The space group is determined by the program XPREP (Bruker, XPREP in SHELXTL v. 6.12, Bruker AXS Inc., Madison, Wis., USA, 2002). From the systematic presence of the following conditions: h00 h=2n; 0k0 k=2n; 00l l=2n, and from subsequent least-squares refinement, the space group is determined to be P2₁2₁2₁ (no. 19). The data are collected to a maximum 2θ value of 55.71°, at a temperature of 150±1 K.

Data Reduction: Frames are integrated with DENZO-SMN (Otwinowski, Z.; Minor, W. Methods Enzymol. 1997, 276, 307). A total of 5812 reflections are collected, of which 2930 are unique. Lorentz and polarization corrections are applied to the data. The linear absorption coefficient is 0.273 mm⁻¹ for Mo Kα radiation. An empirical absorption correction using SCALEPACK (Otwinowski, Z.; Minor, W. Methods Enzymol. 1997, 276, 307) is applied. Transmission coefficients range from 0.953 to 0.953. Intensities of equivalent reflections are averaged. The agreement factor for the averaging is 2.9% based on intensity.

Structure Solution and Refinement: The structure is solved by direct methods using SIR2004 (Burla, M. C., Caliandro, R., Camalli, M., Carrozzini, B., Cascarano, G. L., De Caro, L., Giacovazzo, C., Polidori, G., and Spagna, R., J. Appl. Cryst. 2005, 38, 381). The remaining atoms are located in succeeding difference Fourier syntheses. Hydrogen atoms are included in the refinement but restrained to ride on the atom to which they are bonded. The structure is refined in full-matrix least-squares by minimizing the function:

Σw(|F _(o)|² −|F _(c)|²)²

The weight w is defined as 1/[σ²(F_(o) ²)+(0.0384P)²+(0.2436P)], where P=(F_(o) ²+2F_(c) ²)/3. Scattering factors are taken from the “International Tables for Crystallography” (International Tables for Crystallography, Vol. C, Kluwer Academic Publishers: Dordrecht, The Netherlands, 1992, Tables 4.2.6.8 and 6.1.1.4). Of the 2930 reflections used in the refinements, only the reflections with F_(o) ²>2σ(F_(o) ²) are used in calculating R. A total of 2678 reflections are used in the calculation. The final cycle of refinement includes 162 variable parameters and converges (largest parameter shift is <0.01 times its estimated standard deviation) with unweighted and weighted agreement factors of:

R=Σ|F _(o) −F _(c) |/ΣF _(o)=0.033

R _(w)=√{square root over ((Σw(F _(o) ² −F _(c) ²)² /Σw(F _(o) ²)²))}=0.080

The standard deviation of an observation of unit weight (goodness of fit) is 1.066. The highest peak in the final difference Fourier has a height of 0.19 e/Å³. The minimum negative peak has a height of −0.24 e/Å³. The Flack factor for the determination of the absolute structure (Flack, H. D. Acta Cryst. 1983, A39, 876) refines to −0.02(6).

Calculated X-Ray Powder Diffraction (XRPD) Pattern: A calculated XRPD pattern is generated for Cu radiation using PowderCell 2.3 (PowderCell for Windows Version 2.3 Kraus, W.; Nolze, G. Federal Institute for Materials Research and Testing, Berlin Germany, E U, 1999) and the atomic coordinates, space group, and unit cell parameters from the single crystal data. Because the single crystal data are collected at low temperatures (150 K), peak shifts may be evident between the pattern calculated from low temperature data and the room temperature experimental powder diffraction pattern, particularly at high diffraction angles.

ORTEP and Packing Diagrams: The ORTEP diagram is prepared using the ORTEP III (Johnson, C. K. ORTEPIII, Report ORNL-6895, Oak Ridge National Laboratory, TN, U.S.A. 1996. OPTEP-3 for Windows V1.05, Farrugia, L. J., J. Appl. Cryst. 1997, 30, 565) program within the PLATON (Spek, A. L. PLATON. Molecular Graphics Program. Utrecht University, Utrecht, The Netherlands, 2008. Spek, A. L, J. Appl. Cryst. 2003, 36, 7) software package. Atoms are represented by 50% probability anisotropic thermal ellipsoids. Packing diagrams are prepared using CAMERON (Watkin, D. J.; Prout, C. K.; Pearce, L. J. CAMERON, Chemical Crystallography Laboratory, University of Oxford, Oxford, 1996) modeling software. Assessment of chiral centers are performed with the PLATON (Spek, A. L. PLATON. Molecular Graphics Program. Utrecht University, Utrecht, The Netherlands, 2008. Spek, A. L, J. Appl. Cryst. 2003, 36, 7) software package. Absolute configuration is evaluated using the specification of molecular chirality rules (Cahn, R. S.; Ingold, C; Prelog, V. Angew. Chem. Intern. Ed. Eng., 1966, 5, 385; Prelog, V. G. Helmchen Angew. Chem. Intern. Ed. Eng., 1982, 21, 567). Additional figures are generated with the Mercury 2.4 (Macrae, C. F. Edgington, P. R. McCabe, P. Pidcock, E. Shields, G. P. Taylor, R. Towler M. and van de Streek, J.; J. Appl. Cryst., 2006, 39, 453-457) visualization package. Hydrogen bonding is represented as dashed lines.

Results: The orthorhombic cell parameters and calculated volume are: a=5.7779(2) A, b=8.6633(2) A, c=25.7280(8) A, α=β=γ=90°, V=1287.83(7) Å³. The formula weight of the asymmetric unit in the crystal structure is 245.75 g mol⁻¹ with Z=4, resulting in a calculated density of 1.267 g cm⁻³. The space group is determined to be P2₁2₁2₁. A summary of the crystal data and crystallographic data collection parameters are provided in Table 2 below.

The R-value is 0.033 (3.3%).

An ORTEP drawing of Crystalline Form A is shown in FIG. 18.

The asymmetric unit, shown in FIG. 18, contains a protonated (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane molecule and a chloride counter ion. The proton is located in the difference map and allowed to refine freely on the nitrogen, indicating salt formation.

Packing diagrams viewed along the a, b, and c crystallographic axes are shown in FIGS. 19-21, respectively. Hydrogen bonding occurs between the chlorine and nitrogen atoms, and the structure consists of infinite one-dimensional hydrogen bonded chains along the crystallographic a axis, shown in FIG. 22.

The absolute structure can be determined through an analysis of anomalous X-ray scattering by the crystal. A refined parameter x, known as the Flack parameter (Flack, H. D.; Bernardinelli, G., Acta Cryst., 1999, A55, 908; Flack, H. D.; Bernardinelli, G., J. Appl. Cryst., 2000, 33, 1143), encodes the relative abundance of the two components in an inversion twin. The structure contains a fraction 1−x of the model being refined, and x of its inverse. Provided that a low standard uncertainty is obtained, the Flack parameter should be close to 0 if the solved structure is correct, and close to 1 if the inverse model is correct. The measured Flack parameter for the structure of Crystalline Form A shown in FIG. 18 is −0.02 with a standard uncertainty of 0.06.

After a structure is solved the quality of the data may be assessed for its inversion-distinguishing power, which is done by an examination of the standard uncertainty of the Flack parameter. For Crystalline Form A, the standard uncertainty, (u), equals 0.06, which indicates strong inversion-distinguishing power. The compound is enantiopure and absolute structure can be assigned directly from the crystal structure.

Refinement of the Flack parameter (x) (Flack, H. D. Acta Cryst. 1983, A39, 876) does not result in a quantitative statement about the absolute structure assignment. However, an approach applying Bayesian statistics to Bijvoet differences can provide a series of probabilities for different hypotheses of the absolute structure (Hooft, R. W., J. Appl. Cryst., 2008, 41, 96-103; Bijvoet, J. M.; Peederman, A. F.; van Bommel, A. J., Nature 1951, 168, 271). This analysis provides a Flack equivalent (Hooft) parameter in addition to probabilities that the absolute structure is either correct, incorrect or a racemic twin. For the current data set the Flack equivalent (Hooft) parameter is determined to be −0.01(3), the probability that the structure is correct is 1.000, the probability that the structure is incorrect is 0.000 and the probability that the material is a racemic twin is 0.4⁻⁵⁹.

The structure contains two chiral centers located at C11 and C15 (see FIG. 18, ORTEP drawing), which are assigned as R and S configuration, respectively.

FIG. 23 shows a calculated X-ray powder diffraction pattern of Crystalline Form A, generated from the single crystal data.

The experimental X-ray powder diffraction pattern of Crystalline Form A is shown in FIG. 1.

The experimental XRPD of Crystalline Form A from FIG. 1 is overlaid with the calculated pattern in FIG. 34.

Differences in intensities between the calculated and experimental x-ray powder diffraction patterns often are due to preferred orientation. Preferred orientation is the tendency for crystals to align themselves with some degree of order. This preferred orientation of the sample can significantly affect peak intensities, but not peak positions, in the experimental powder diffraction pattern. Furthermore, some shift in peak position between the calculated and experimental powder diffraction patterns may be expected because the experimental powder pattern is collected at ambient temperature and the single crystal data is collected at 150 K. Low temperatures are used in single crystal analysis to improve the quality of the structure but can contract the crystal resulting in a change in the unit cell parameters, which is reflected in the calculated powder diffraction pattern. These shifts are particularly evident at high diffraction angles.

Tables of positional parameters and their estimated standard deviations (Table 3), anisotropic temperature factor coefficients (Table 4), bond distances (Table 5), bond angles (Table 6), hydrogen bonds and angles (Table 7) and torsion angles (Table 8) are provided below.

TABLE 2 Crystal Data and Data Collection Parameters for (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride Form A (Crystalline Form A) formula C₁₅H₁₆ClN formula weight 245.75 space group P2₁2₁2₁ (No. 19) a, Å 5.7779(2) b, Å 8.6633(2) c, Å 25.7280(8) V, Å³ 1287.83(7) Z 4 d_(calc), g cm⁻³ 1.267 crystal dimensions, mm 0.38 × 0.30 × 0.18 temperature, K 150 radiation (wavelength, Å) Mo K_(α) (0.71073) monochromator graphite linear abs coef, mm⁻¹ 0.273 absorption correction applied empirical^(a) transmission factors: min, max 0.953, 0.953 diffractometer Nonius Kappa CCD h, k, l range −7 to 7 −11 to 11 −33 to 33 2θ range, deg 1.58-55.71 mosaicity, deg 0.38 programs used SHELXTL F₀₀₀ 520.0 weighting 1/[σ²(F_(o) ²) + (0.0384P)² + 0.2436P] where P = (F_(o) ² + 2F_(c) ²)/3 data collected 5812 unique data 2930 R_(int) 0.029 data used in refinement 2930 cutoff used in R-factor calculations F_(o) ² > 2.0σ(F_(o) ²) data with I > 2.0σ(I) 2678 number of variables 162 largest shift/esd in final cycle 0.00 R(F_(o)) 0.033 R_(w)(F_(o) ²) 0.080 goodness of fit 1.066 absolute structure determination Flack parameter^(b) (−0.02(6)) Hooft parameter^(c) (−0.01(3)) Friedel Coverage 90% ^(a)Otwinowski, Z.; Minor, W. Methods Enzymol. 1997, 276, 307. ^(b)Flack, H. D. Acta Cryst., 1983 A39, 876. ^(c)Hooft, R. W. W., Straver, L. H., and Spek, A. L. J. Appl. Cryst., 2008, 41, 96-103.

TABLE 3 Positional Parameters and Their Estimated Standard Deviations for Crystalline Form A Atom x y z U(Å²) Cl1 −0.21843(7) 1.09587(4) 0.483829(15) 0.02856(9) N13 0.2878(3) 1.04618(14) 0.53004(5) 0.0234(3) C1 0.4183(3) 0.93704(19) 0.70605(6) 0.0294(4) C2 0.2847(3) 0.88296(17) 0.66572(6) 0.0268(4) C3 0.0828(3) 0.7983(2) 0.67700(7) 0.0380(5) C4 0.0151(3) 0.7719(3) 0.72723(8) 0.0426(6) C5 0.1497(3) 0.8274(2) 0.76923(7) 0.0340(5) C6 0.0855(4) 0.8007(3) 0.82173(8) 0.0465(6) C7 0.2208(4) 0.8543(2) 0.86149(7) 0.0483(6) C8 0.4249(4) 0.9340(2) 0.85125(7) 0.0447(6) C9 0.4915(4) 0.9627(2) 0.80087(7) 0.0391(5) C10 0.3549(3) 0.9099(2) 0.75855(6) 0.0294(4) C11 0.3521(3) 0.91598(19) 0.61066(6) 0.0261(4) C12 0.2704(3) 1.06743(16) 0.58785(5) 0.0270(4) C14 0.2577(3) 0.87808(16) 0.51906(6) 0.0282(4) C15 0.3409(3) 0.7984(2) 0.56741(7) 0.0314(5) C16 0.5712(3) 0.8497(2) 0.58846(7) 0.0352(5) H131 0.436(4) 1.082(2) 0.5177(8) 0.036(5)* H132 0.168(4) 1.105(2) 0.5138(7) 0.039(5)* H1 0.555 0.993 0.699 0.035 H3 −0.008 0.759 0.649 0.046 H4 −0.123 0.716 0.734 0.051 H6 −0.052 0.745 0.829 0.056 H7 0.175 0.837 0.896 0.058 H8 0.519 0.969 0.879 0.054 H9 0.630 1.018 0.794 0.047 H15 0.285 0.692 0.575 0.038 H12A 0.109 1.089 0.598 0.032 H12B 0.370 1.154 0.600 0.032 H14A 0.351 0.847 0.489 0.034 H14B 0.093 0.853 0.512 0.034 H16A 0.659 0.776 0.610 0.042 H16B 0.667 0.918 0.566 0.042 Starred atoms are refined isotropically U_(eq) = (1/3)Σ_(i)Σ_(j) U_(ij)a*_(i)a*_(j)a_(i).a_(j) Hydrogen atoms are included in calculation of structure factors but not refined

TABLE 4 Anisotropic Temperature Factor Coefficients − U's for Crystalline Form A Name U(1, 1) U(2, 2) U(3, 3) U(1, 2) U(1, 3) U(2, 3) C11 0.02543(19) 0.02561(17) 0.03463(19) 0.00075(15) 0.00262(16) 0.00196(16) N13 0.0268(7) 0.0213(6) 0.0222(6) 0.0008(6) −0.0013(6) −0.0002(5) C1 0.0292(9) 0.0301(9) 0.0290(8) −0.0056(7) 0.0005(7) 0.0014(7) C2 0.0258(8) 0.0290(8) 0.0256(7) 0.0017(7) −0.0019(6) 0.0053(6) C3 0.0278(9) 0.0550(12) 0.0313(9) −0.0099(9) −0.0063(8) 0.0089(8) C4 0.0286(10) 0.0605(13) 0.0388(11) −0.0118(10) −0.0015(8) 0.0154(10) C5 0.0326(10) 0.0394(10) 0.0301(8) 0.0019(8) 0.0016(7) 0.0094(8) C6 0.0458(12) 0.0584(13) 0.0354(10) −0.0020(11) 0.0068(10) 0.0160(9) C7 0.0664(14) 0.0518(11) 0.0266(8) 0.0055(12) 0.0037(10) 0.0084(8) C8 0.0628(14) 0.0437(12) 0.0276(9) 0.0012(10) −0.0062(9) −0.0020(8) C9 0.0479(12) 0.0386(10) 0.0309(10) −0.0053(9) −0.0015(8) −0.0037(8) C10 0.0334(9) 0.0282(8) 0.0265(8) 0.0020(7) −0.0002(6) 0.0017(7) C11 0.0252(8) 0.0282(8) 0.0249(7) −0.0008(7) −0.0014(6) 0.0018(7) C12 0.0352(9) 0.0244(7) 0.0215(7) −0.0015(7) 0.0001(7) −0.0019(5) C14 0.0343(8) 0.0221(7) 0.0283(7) 0.0013(6) −0.0041(7) −0.0040(6) C15 0.0393(11) 0.0245(8) 0.0303(8) 0.0047(7) −0.0011(7) 0.0004(7) C16 0.0308(9) 0.0452(10) 0.0297(8) 0.0105(8) 0.0006(7) 0.0081(8) The form of the anisotropic temperature factor is: exp[−2π h²a*²U(1, 1) + k²b*²U(2, 2) + l²c*²U(3, 3) + 2hka*b*U(1, 2) + 2hla*c*U(1, 3) + 2klb*c*U(2, 3)] where a*, b*, and c* are reciprocal lattice constants.

TABLE 5 Bond Distances in Angstroms for Crystalline Form A Atom 1 Atom 2 Distance Atom 1 Atom 2 Distance N13 C14 1.4936(18) C7 H7 0.950 N13 C12 1.5023(18) C8 C9 1.375(3) N13 H131 0.96(2) C8 H8 0.950 N13 H132 0.96(2) C9 C10 1.420(3) C1 C2 1.376(2) C9 H9 0.950 C1 C10 1.419(2) C11 C16 1.503(2) C1 H1 0.950 C11 C15 1.510(2) C2 C3 1.408(2) C11 C12 1.513(2) C2 C11 1.497(2) C12 H12A 0.990 C3 C4 1.370(3) C12 H12B 0.990 C3 H3 0.950 C14 C15 1.501(2) C4 C5 1.415(3) C14 H14A 0.990 C4 H4 0.950 C14 H14B 0.990 C5 C10 1.412(3) C15 C16 1.504(3) C5 C6 1.420(3) C15 H15 1.000 C6 C7 1.369(3) C16 H16A 0.990 C6 H6 0.950 C16 H16B 0.990 C7 C8 1.391(3) Numbers in parentheses are estimated standard deviations in the least significant digits.

TABLE 6 Bond Angles in Degrees for Crystalline Form A Atom 1 Atom 2 Atom 3 Angle Atom 1 Atom 2 Atom 3 Angle C14 N13 C12 107.39(11) C5 C10 C1 119.08(16) C14 N13 H131 110.6(12) C5 C10 C9 118.71(16) C12 N13 H131 110.3(12) C1 C10 C9 122.21(17) C14 N13 H132 110.8(13) C2 C11 C16 120.40(14) C12 N13 H132 108.7(12) C2 C11 C15 123.87(14) H131 N13 H132 109.2(16) C16 C11 C15 59.90(12) C2 C1 C10 121.10(16) C2 C11 C12 116.85(14) C2 C1 H1 119.50 C16 C11 C12 116.53(15) C10 C1 H1 119.50 C15 C11 C12 106.60(13) C1 C2 C3 119.14(15) N13 C12 C11 104.89(12) C1 C2 C11 120.17(15) N13 C12 H12A 110.80 C3 C2 C11 120.69(15) C11 C12 H12A 110.80 C4 C3 C2 121.22(17) N13 C12 H12B 110.80 C4 C3 H3 119.40 C11 C12 H12B 110.80 C2 C3 H3 119.40 H12A C12 H12B 108.80 C3 C4 C5 120.43(18) N13 C14 C15 104.74(12) C3 C4 H4 119.80 N13 C14 H14A 110.80 C5 C4 H4 119.80 C15 C14 H14A 110.80 C10 C5 C4 119.01(16) N13 C14 H14B 110.80 C10 C5 C6 119.16(17) C15 C14 H14B 110.80 C4 C5 C6 121.82(18) H14A C14 H14B 108.90 C7 C6 C5 120.4(2) C14 C15 C16 116.45(15) C7 C6 H6 119.80 C14 C15 C11 108.31(14) C5 C6 H6 119.80 C16 C15 C11 59.81(11) C6 C7 C8 120.71(18) C14 C15 H15 119.20 C6 C7 H7 119.60 C16 C15 H15 119.20 C8 C7 H7 119.60 C11 C15 H15 119.20 C9 C8 C7 120.36(19) C11 C16 C15 60.29(12) C9 C8 H8 119.80 C11 C16 H16A 117.70 C7 C8 H8 119.80 C15 C16 H16A 117.70 C8 C9 C10 120.6(2) C11 C16 H16B 117.70 C8 C9 H9 119.70 C15 C16 H16B 117.70 C10 C9 H9 119.70 H16A C16 H16B 114.90 Numbers in parentheses are estimated standard deviations in the least significant digits.

TABLE 7 Hydrogen Bond Distances in Angstroms and Angles in Degrees for Crystalline Form A D H A D-H A-H D-A D-H-A N13 H131 C11 0.96(2) 2.18(2) 3.121(2) 164.1(15) N13 H132 C11 0.96(2) 2.36(2) 3.187(2) 144.0(15) N13 H132 C11 0.96(2) 2.674(18) 3.1217(19) 109.2(14) Numbers in parentheses are estimated standard deviations in the least significant digits.

TABLE 8 Torsion Angles in Degrees for Crystalline Form A Atom 1 Atom 2 Atom 3 Atom 4 Angle C14 N13 C12 C11 28.20 (0.18) C12 N13 C14 C15 −27.51 (0.18) C10 C1 C2 C3 −0.50 (0.25) C10 C1 C2 C11 178.63 (0.15) C2 C1 C10 C5 −0.71 (0.25) C2 C1 C10 C9 179.13 (0.16) C1 C2 C3 C4 1.39 (0.26) C11 C2 C3 C4 −177.73 (0.18) C1 C2 C11 C12 −85.92 (0.20) C1 C2 C11 C15 137.54 (0.17) C1 C2 C11 C16 65.41 (0.21) C3 C2 C11 C12 93.19 (0.19) C3 C2 C11 C15 −43.34 (0.24) C3 C2 C11 C16 −115.47 (0.18) C2 C3 C4 C5 −1.05 (0.30) C3 C4 C5 C6 −179.38 (0.20) C3 C4 C5 C10 −0.18 (0.30) C4 C5 C6 C7 179.21 (0.21) C10 C5 C6 C7 0.02 (0.46) C4 C5 C10 C1 1.04 (0.26) C4 C5 C10 C9 −178.80 (0.18) C6 C5 C10 C1 −179.74 (0.18) C6 C5 C10 C9 0.42 (0.27) C5 C6 C7 C8 −0.85 (0.33) C6 C7 C8 C9 1.25 (0.30) C7 C8 C9 C10 −0.80 (0.29) C8 C9 C10 C1 −179.87 (0.17) C8 C9 C10 C5 −0.03 (0.25) C2 C11 C12 N13 −160.97 (0.14) C15 C11 C12 N13 −17.56 (0.17) C16 C11 C12 N13 46.58 (0.18) C2 C11 C15 C14 141.11 (0.16) C2 C11 C15 C16 −108.36 (0.18) C12 C11 C15 C14 0.94 (0.18) C12 C11 C15 C16 111.47 (0.15) C16 C11 C15 C14 −110.53 (0.16) C2 C11 C16 C15 114.01 (0.17) C12 C11 C16 C15 −94.57 (0.15) N13 C14 C15 C11 16.15 (0.18) N13 C14 C15 C16 −48.59 (0.19) C14 C15 C16 C11 96.68 (0.16) Numbers in parentheses are estimated standard deviations in the least significant digits.

Example 3—Preparation of Crystalline Forms A Through F

Crystalline Form A through Form F are prepared as follows by using Crystalline Form A obtained from Example 1 above. A variety of crystallization techniques are used, including evaporation, cooling, solvent/antisolvent precipitation, slurry, vapor stress, and vapor diffusion, as described above. The results are presented in Table 9 below:

TABLE 9 XRPD Solvent Method^(a) Observations Result — 40° C./75% off-white solids, A RH/7 d irregular, B/E chloroform SE off-white solids, A needles, B/E chloroform/ VD/RT/7 d off-white solids, A heptane needles, B/E chloroform/ VD/RT/7 d off-white solids, A toluene irregular, B/E DCM SE off-white solids, A + B needles, B/E VS/RT/7 d off-white solids, A irregular, B/E slurry/RT/7 d off-white solids, B (for XRPD needles, B/E see FIGS. 4B, 5, 6, and 7; for DSC and TGA see FIG. 8) SC (40° C. to RT, off-white solids, B refrigerator/2 d, needles, B/E freezer/8 d) CC (40° C. to dry milky solution B ice/IPA) freezer/9 d off-white solids, needles, B/E DCM/ACN VD/RT/7 d off-white solids, A needles, B/E DCM/MEK VD/RT/7 d off-white solids, A needles, B/E EtOH FE off-white solids, A + B irregular, B/E VS/RT/7 d off-white solids, A irregular, B/E slurry/RT/7 d off-white solids, A irregular, B/E SC (70° C. to RT, off-white solids, A + weak C refrigerator/2 d, irregular, B/E peaks freezer/8 d) CC (70° C. to dry milky solution C + weak A ice/IPA) peaks freezer/2 d off-white solids, (~18.5, 20.7, irregular, B/E 25.7 °2θ) EtOH/acetone VD/RT/9 d no solids — acetone addition no solids EtOH/hexanes VD/RT/7 d off-white solids, A irregular, B/E EtOH/THF VD/RT/9 d no solids — HFIPA SE off-white solids, A + weak B irregular, B/E peaks HFIPA/IPE AS precipitation off-white solids, A + weak irregular, B/E peak (~18.9 °2θ) HFIPA/THF AS precipitation off-white solids, A irregular, B/E IPA FE off-white solids, A irregular, B/E slurry/RT/7 d off-white solids, A irregular, B/E SC (70° C. to RT, off-white solids, C (for XRPD refrigerator/2 d, needles, B/E see FIGS. freezer/7 d) 4C, 9, and 13G; for DSC and TGA see FIG. 12)^(b) CC (70° C. to dry milky solution C + possible ice/IPA) weak A peak freezer/2 d off-white solids, (~25.7 °2θ) irregular, B/E (after 22 days of ambient storage: C + possible weak A peaks (~12.3, 15.4, 16.6, 20.7, 25.7 °2θ, for XRPD see FIGS. 10 and 11)^(c) MeOH SE off-white solids, A irregular, B/E MeOH:acetone FE off-white solids, A (1:5) irregular, B/E MeOH/dioxane VD/RT/7 d off-white solids, A needles, B/E MeOH/EtOAc VD/RT/7 d plates, single — crystal MeOH/EtOAc VD/RT/7 d plates — MeOH/IPE VD/RT/7 d very thin plates, A possible single crystal MeOH:toluene FE off-white solids, A (1:5) needles, B/E 1-propanol FE off-white solids, A irregular, B/E slurry/RT/7 d off-white solids, A irregular, B/E 1-propanol SC (70° C. to RT, off-white solids, B refrigerator/2 d) needles, B/E CC (70° C. to dry milky solution ice/IPA) freezer/2 d off-white solids, B + weak A needles, B/E and C peaks (~17.8, 18.5, 20.7 °2θ) TFE SE light-orange solids, A + weak B irregular, B/E peaks TFE/ACN AS precipitation off-white solids, A needles, B/E TFE/EtOAc AS precipitation off-white solids, A needles, B/E TFE/MEK AS precipitation off-white solids, A needles, B/E water FE off-white solids, B irregular, B/E slurry/RT/7 d off-white solids, B irregular, B/E dioxane:water FE off-white solids, A (1:1) irregular, B/E ^(a)Reported temperatures, times, and RH value are approximate. ^(b)About 25 mg scale. Concentration of IPA solution: 10 mg/mL. ^(c)About 27 mg scale. Concentration of IPA solution: 10 mg/mL.

Crystalline Form B—

As summarized above, Crystalline Form B is obtained from evaporation and slurry in water, slurry, slow and crash cooling in DCM, as well as slow cooling in 1-propanol. In addition, materials exhibiting XRPD patterns of Crystalline Form A with Crystalline Form B peaks result from evaporation in DCM, ethanol, HFIPA, and TFE. Material exhibiting XRPD pattern of Crystalline Form B with weak Crystalline Form A and Crystalline Form C peaks is observed from a crash cooling experiment in 1-propanol.

Crystalline Form B is indexed from a high-resolution XRPD pattern using X'Pert High Score Plus (X'Pert High Score Plus 2.2a (2.2.1)) (FIG. 6, high-resolution XRPD pattern also shown in FIG. 7). The pattern appears to represent a mixture of Crystalline Forms B and A. Agreement between the allowed peak positions, marked with bars for the current form and the observed peaks indicates a consistent unit cell determination. Peaks at 18.5°, 20.7°, 25.7°, and 27.5° two-theta are not consistent with the indexing solution of Crystalline Form B and are likely from Crystalline Form A. Space groups consistent with the assigned extinction symbol, unit cell parameters, and derived quantities are tabulated below the figure. To confirm the tentative indexing solution, the molecular packing motifs within the crystallographic unit cell must be determined. No attempts at molecular packing are performed. Crystalline Form B is indexed with a similar volume per formula unit compared to Crystalline Form A, suggesting Crystalline Form B is an unsolvated crystalline form.

XRPD Data acquisition parameters for FIGS. 4B and 5: INEL XRG-3000, X-ray Tube: 1.54187100 Å, Voltage: 40 (kV), Amperage: 30 (mA), Acquisition Time: 300 sec, Spinning capillary, Step size: approximately 0.03° 2θ.

XRPD Data acquisition parameters for FIGS. 6 and 7: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 1939 s, Scan Speed: 1.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

Characterization data for Crystalline Form B are summarized in Table 10 below:

TABLE 10 Analysis Result XRPD B (for XRPD see FIGS. 4B and 5) B + possible weak A peaks^(b) (~18.5, 20.7, 25.7, 27.5 °2θ) (for XRPD see FIGS. 6 and 7) DSC^(a) 141° C. (endo, peak; 137° C. onset); 248° C. (endo, peak; 246° C. onset); 251° C. (endo, peak); 264° C. (endo, peak) (for DSC see FIG. 8) TGA^(a) 0.2% weight loss up to 200° C. 281° C. (onset, decomposition) (for TGA see FIG. 8) ^(a)Temperatures are rounded to the nearest ° C.; weight loss values are rounded to one decimal place. ^(b)High-resolution XRPD.

The thermal analysis results for Crystalline Form B are shown in FIG. 8 (DSC, Size: 1.2600 mg, Method: (−30)-300-10, TOC; TGA, Size: 9.4320 mg, Method: 00-350-10). By TGA, Crystalline Form B exhibits a small weight loss of approximately 0.2% from ambient to 200° C., possibly due to trace amounts of solvent. The dramatic change in the slope of the TGA thermogram at approximately 281° C. is consistent with decomposition. By DSC, a broad endotherm observed at approximately 141° C. (peak) is suspected to be attributed to either a solid form change or possibly a loss of volatiles on heating. Crystalline Form B displays an endotherm at approximately 248° C. (peak), similar to the thermal behavior observed for Crystalline Form A, followed by two broad endotherms at approximately 251 and 264° C. Based on the data obtained, Crystalline Form B is an unsolvated, crystalline material.

Crystalline Form C—

Crystalline Form C may be made by slow cooling in isopropanol. Material exhibiting XRPD pattern of Crystalline Form A with weak Crystalline Form C peaks results from a slow cooling experiment in ethanol; while the crash cooling experiments in ethanol and isopropanol afford XRPD pattern Crystalline Form C with weak Crystalline Form A peaks.

Six scale-up attempts are conducted to prepare Crystalline Form C by cooling in isopropanol on approximately 50-150 mg scale (Table 11) and the solids tested by XRPD. At refrigerator temperature, precipitated solids yield Form B. Seeding with Form C after cooling in the refrigerator (no solids observed) and before placing in the freezer yield XRPD pattern of Form C with B peaks. Precipitation at freezer temperature results in solids with an XRPD pattern of Form C with A peaks. A solution placed in the freezer after cooling to room temperature with a lower concentration (7 mg/mL compared to 10 mg/mL) yields Form B. By crash cooling (ambient solution placed into dry ice/isopropanol), solids generated are a mixture of Forms B and A. The last attempt on an approximate 50-mg scale generates a mixture of Forms A and C. The different outcomes of these experiments suggest possible factors affecting the crystallization of Form C on a larger scale (e.g., concentration, temperature, cooling time, and seeding), and competitive crystallization of Forms A and B that are possibly more stable under the experimental conditions used. Note that Form C remains unchanged by XRPD after 22 days of ambient storage.

XRPD Data acquisition parameters for FIGS. 13A, C, and F: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 717 s, Scan Speed: 3.3°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

XRPD Data acquisition parameters for FIG. 13B: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 720 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

XRPD Data acquisition parameters for FIG. 13D: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 718 s, Scan Speed: 3.3°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

XRPD Data acquisition parameters for FIG. 13E: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54060 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 720 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

TABLE 11 Attempted XRPD material Solvent Method^(a) Observations Result C IPA SC (70° C. to RT, off-white solids, B (for refrigerator/2 d) needles, B/E^(b) XRPD see FIG. 13A) SC (70° C. to RT, off-white solids, C + B (for refrigerator/4 h, irregular & XRPD see freezer/3 d) needles, B/E^(c,d) FIG. 13B) SC (70° C. to RT, off-white solids, C + A (for refrigerator/4 h, irregular & XRPD see freezer/2 d) needles, B/E^(c) FIG. 13C) SC (70° C. to RT, off-white solids, B (for freezer/7 d) irregular, B/E^(e) XRPD see FIG. 13D) CC (70° C. to off-white solids, B + A (for dry ice/IPA/4 h) irregular, B/E^(c) XRPD see FIG. 13E) SC (70° C. to RT, off-white solids, A + C (for refrigerator/4 h, irregular, B/E^(c) XRPD see freezer/3 d) FIG. 13F) ^(a)Reported temperatures and times are approximate. ^(b)Concentration of IPA solution: 11 mg/mL. ^(c)Concentration of IPA solution: 10 mg/mL. ^(d)Seeded with Crystalline Form C (for XRPD of seeds see FIGS. 4C and 9) before moving into the freezer. ^(e)Concentration of IPA solution: 7 mg/mL.

Form C is indexed from a high-resolution XRPD pattern (FIG. 10) using proprietary software. The pattern appears to represent a mixture of Forms C and A. Agreement between the allowed peak positions, marked with bars for the current form and the observed peaks indicates a consistent unit cell determination. Peaks at 12.3°, 15.4°, 16.6°, 20.7°, and 25.7° two-theta are not consistent with the indexing solution of Form C and are likely from Form A. Space groups consistent with the assigned extinction symbol, unit cell parameters, and derived quantities are tabulated below the figure. To confirm the tentative indexing solution, the molecular packing motifs within the crystallographic unit cell must be determined. No attempts at molecular packing are performed. Form C is indexed with a similar volume per formula unit compared to Form A, suggesting Form C is an unsolvated crystalline form.

XRPD Data acquisition parameters for FIGS. 4C, 9, and 13G: INEL XRG-3000, X-ray Tube: 1.54187100 Å, Voltage: 40 (kV), Amperage: 30 (mA), Acquisition Time: 300 sec, Spinning capillary, Step size: approximately 0.03° 2θ.

XRPD Data acquisition parameters for FIGS. 10 and 11: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 720 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

Characterization data for Form C are summarized in Table 12 below:

TABLE 12 Analysis Result XRPD C (for XRPD see FIGS. 4C, 9, and 13G) DSC^(a) 122° C. (endo, peak; 112° C. onset); 248° C. (endo, peak; 246° C. onset; ΔH: 88 J/g); 271° C. (endo, peak) (for DSC see FIG. 12) TGA^(a) 1.3% weight loss up to 200° C. 266° C. (onset, decomposition) (for TGA see FIG. 12) XRPD C + possible weak A peak (~25.7 °2θ) C + possible weak A peaks^(b) (for XRPD see FIGS. 10 and 11) (~12.3, 15.4, 16.6, 20.7, 25.7 °2θ) ^(a)Temperatures are rounded to the nearest ° C.; weight loss values are rounded to one decimal place; reported ΔH values are rounded to the nearest whole number. ^(b)High-resolution XRPD, reanalyzed after 22 days of ambient storage.

The thermal analysis results for Form C are shown in FIG. 12 (DSC, Size: 1.0100 mg, Method: (−30)-300-10, TOC; TGA, Size: 2.2300 mg, Method: 00-350-10). By TGA, Form C exhibits a weight loss of approximately 1.3% from ambient to 200° C., possibly due to loss of volatiles upon heating. The dramatic change in the slope of the TGA thermogram at approximately 266° C. is consistent with decomposition. By DSC, a broad small endotherm observed at approximately 122° C. (peak) is suspected to be attributed to either a solid form change or possibly a loss of volatiles on heating. Form C displays an endotherm at approximately 248° C. (peak), similar to the thermal behavior observed for Form A, followed by a broad endotherm at approximately 271° C.

Based on the data obtained, Form C is an unsolvated, crystalline material.

Crystalline Forms D, E, and F—

Crystalline Form A is dissolved in pH adjusted buffered media. Undissolved solid or precipitate observed is analyzed by XRPD. Some experiments are conducted at elevated temperature to increase solubility, the undissolved solids are also analyzed by XRPD. The resulting Crystalline Forms D, E, and F are generated during these experiments as summarized in Table 13 below.

XRPD Data acquisition parameters for FIGS. 14D-F: INEL XRG-3000, X-ray Tube: 1.54187100 Å, Voltage: 40 (kV), Amperage: 30 (mA), Acquisition Time: 300 sec, Spinning capillary, Step size: approximately 0.03° 2θ.

TABLE 13 XRPD pH Buffer Method^(a) Observations Result pH 2.0 slurry/RT/7 d off-white solids, A (50 mM irregular, B/E KCl/HCl) SC (70° C. to RT) off-white solids, A irregular, B/E pH 4.4 spontaneous off-white solids, D (50 mM citric precipitation irregular, B/E acid/sodium slurry/RT/7 d off-white solids, B + weak citrate) irregular, B/E D peaks stir at 70° C./ off-white solids, D (for 30 min irregular, B/E XRPD see FIG. 14D) pH 6.0 slurry/50° C./3 d off-white solids, E (contains (50 mM irregular, B/E peaks of Na₂HPO₄/ F) (for NaH₂PO₄) XRPD see FIG. 14E) pH 8.1 stir at 70° C./30 min off-white solids, F (for (50 mM irregular, B/E XRPD see Na₂HPO₄/ FIG. 14F) NaH₂PO₄) ^(a)Reported times and temperatures are approximate.

pH 2.0 buffer (50 mM KCl/HCl): Crystalline Form A is recovered from slow cooling (approximately 70° C. to ambient) and slurry at room temperature.

pH 4.4 buffer (50 mM citric acid/sodium citrate): Crystalline Form D results from spontaneous precipitation at room temperature and after stirring a suspension at approximately 70° C.; a room temperature slurry yields Crystalline Form B with weak Crystalline Form D peaks by XRPD.

pH 6.0 buffer (50 mM Na₂HPO₄/NaH₂PO₄): Crystalline Form E with peaks also found in Crystalline Form F by XRPD is observed from slurry at approximately 50° C.

pH 8.1 buffer (50 mM Na₂HPO₄/NaH₂PO₄): Crystalline Form F results from stirring a suspension at approximately 70° C.

Crystalline Forms D, E, and F are characterized by XRPD as shown in FIG. 14.

Example 4—Amorphous

Attempts to prepare amorphous (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride are performed by milling, lyophilization, and rotary evaporation (Table 14). Possible disordered Crystalline Form A materials are recovered from all attempts used in this study.

XRPD Data acquisition parameters for FIGS. 52-55: Bruker Discovery D8, X-ray Tube: Cu (1.54059 Å), Scan Range: 2.14-37.02° 2θ, Step Size: 0.04° 2θ, Acquisition Time: 900 s.

TABLE 14 Conditions^(a) Observations Analysis Results freeze-drying off-white solids, XRPD disordered in dioxane:water aggregates, no B A (for (1:1)/3 d XRPD see FIG. 51) freeze-drying off-white solids, XRPD disordered in water/3 d aggregates, no B A (for XRPD see FIG. 52) milling/30 Hz, off-white solids, XRPD disordered 4 × 10 min aggregates, no B A (for XRPD see FIG. 53) rotary off-white solids, XRPD disordered evaporation aggregates, no B A (for in HFIPA XRPD see FIG. 54) ^(a)Reported times are approximate.

Example 5—Preparation of Crystalline Form A

Commercially available reagents are used as received unless otherwise noted. Reactions requiring an inert atmosphere are run under nitrogen unless otherwise noted.

Step 1 and 2:

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction 2-naphthylacetonitrile 167.21 NA 1.0 mol eq (SM) 4500 g/26.91 mol (S)-(+)-epichlorohydrin 92.52 3.12  1.30 mol eq 3200 g/34.58 mol tetrahydrofuran 72.11 0.889 6.0 ml/g SM 32 L 2M sodium bis(trimethylsilyl)amide  2.0M 0.916 2 mol eq 24700 g/5308 mol  in THF borane-dimethylsulfide 10.0M 0.80  2.5 mol eq 6500 g/67 mol   Isolation 2M HCl (aqueous)   2M NA 11.5 ml/g SM 57000 mL isopropyl acetate 102.13 0.872 4 mL/g SM as required water 18.02 1.00  5 mL/g SM as required ammonia (aqueous) NA 0.889 1.5 mL/g SM 6300 mL 5% aqueous dibasic sodium NA NA 4 mL/g SM 18000 mL phosphate para-toluenesulfonic acid 190.22 NA 0.93 mol eq. 49000 g/8.34 mol  monohydrate

2-naphthylacetonitrile (4500 g) is dissolved in THF (32 L), 3.2 kg of (S)-(+)-epichlorohydrin are added and the solution cooled to −16° C. A 2.0 M solution of sodium hexamethyldisilylazane in tetrahydrofuran (THF) (24.7 kg) is then added, keeping the internal temperature below −10° C. This addition requires 2 hr 45 minutes to complete. The reaction mixture is then stirred an additional six hours at approximately −15° C. after which a sample is analyzed by HPLC. While keeping the internal temperature less than 0° C., borane-dimethylsulfide (6.5 kg) is added over 36 minutes. After completion of the borane addition, the reaction mixture is slowly heated to 60° C. to reduce the nitrile to the amine. During this heat-up, an exotherm is noted which initiates at 45° C. After heating at 60° C. for two hours a sample of the reaction mixture is analyzed by HPLC. The reaction mixture is cooled to 24° C. and transferred to a solution of 2M HCl over 1 hr. The two-phase mixture is heated to 50° C. and stirred for 1 hour at this temperature followed by cooling to 29° C. The pH of the quenched reaction mixture is measured and found to be 5. Additional 2M HCl is added, the mixture heated to 50° C. and stirred for one hour, then cooled to 25° C. The pH is measured and found to be 1. Reaction workup continues by the addition of isopropyl acetate (IPAc), stirring, layer separation, and discard of the organic layer. Aqueous ammonia is added to the aqueous layer and the pH measured, which shows a pH of 8. Additional ammonia is added and the pH re-measured and found to be 8.5. Workup then continues by extraction with two extraction of the aqueous layer with IPAc. The combined organic extracts are then washed with 5% dibasic sodium phosphate in water followed by a brine wash. The resulting organic layer is partially concentrated to azeotropically dry followed by dilution with IPAc. p-Toluenesulfonic acid hydrate (4.9 kg) is then added in portions to precipitate the desired product as its pTsOH salt, which is isolated by filtration. The filtercake is washed with IPAc and then dried to a constant weight to give 5785 g of the desired product as a white solid. Yield: 54%. HPLC: 98.2%.

Step 3 and 4:

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction 2-naphthylcyclopropylamine-tosylate 399.51 NA 1.0 mol eq  5785 g/145.18 mol salt isopropylacetate 102.13 0.872 as required 176 L thionyl chloride 118.97 1.638 1.2 eq 2.1 Kg/17.65 mol 5M NaOH 5.0M NA 6.0 mol eq. 16.7 Kg Isolation magnesium sulfate NA NA 0.5 g/g 2.9 Kg hydrogen chloride in isopropyl alcohol 5.7M NA 1.0 mol eq. 0.90 L isopropyl alcohol 60.1 0.786 1.5 mL/g as required Ethyl alcohol 200 (special industrial 80.25 0.786 1.5 mL/g as required denatured)

Step 3:

The amine-pTsOH salt (5785 g) obtained from step 2 is suspended in IPAc (176 L) to give a slurry. Thionyl chloride (2.1 kg) is then added over one hour. Upon completion of the thionyl chloride addition the reaction mixture is stirred one additional hour and a sample is analysed by HPLC. Aqueous sodium hydroxide (5M, 6 mol equivalents) is added over one hour followed by four hours of additional stirring. The layers are allowed to settle and the pH of the aqueous layer is found to be 9. The layers are separated and the organic layer washed with 1M NaOH in water. The aqueous layers are combined and back extracted with IPAc and the initial organic layer and the back extract combined. These combined organic layers are washed with 0.5M HCl to extract (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane into the aqueous layer. The acidic aqueous layer is washed with a 1:1 mixture of IPAc and THF to remove color. The aqueous layer is basified with aqueous ammonia followed by extraction with IPAc. After layer separation the organic layer is washed with brine, dried over magnesium sulfate, and partially concentrated. After the concentration, hydrogen chloride in isopropyl alcohol (IPA) (1.0 mol equivalent of HCl, 0.90 L) is added to form the crude salt, which is isolated by filtration, washed with IPAc and then partially dried. The wet cake is refluxed in IPAc. The crude salt is refluxed in IPA and the solids isolated by filtration, washed with IPA, and then dried. >99.5 HPLC area percent and 97.7% chiral area percent purity. 1759 g of the desired product.

Step 4:

The crude (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride (1753 g) obtained from step 3 is dissolved in 20 volumes of hot ethanol (70° C.) and then filtered via an inline filter as a polish filtration. The dissolution vessel and the inline filter and transfer line are then rinsed with additional hot ethanol (61° C.) and the rinse combined with the filtrate. The combined filtrate and washes are partially concentrated in vacuo to approximately 11.5 total volumes (relative to crude (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride input) and then reheated to redissolve the solids. The solution is cooled to 65° C. and seed crystals added as slurry in ethanol. After stirring at approx. 65° C. to develop the seed bed, the slurry is cooled to room temperature. The resulting solids are isolated by filtration, the filtercake is washed with ethanol, and the washed solids dried. A total of 1064 g of tan product is obtained. >99.5% for both chiral and achiral HPLC.

Step 5:

The (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride (1064 g) obtained from step 4 is dissolved in 10.7 L of water while warming to 35° C. Once all solids dissolve, the aqueous solution is washed with 1:1 THF:IPAc to remove most of the color. After the wash, aqueous ammonia is added to the aqueous layer and (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane is extracted into IPAc. The organic layer is dried over magnesium sulfate and then concentrated in vacuo to give an off-white solid. The solid is dissolved in IPA and transferred to a 22 L 3-neck round bottom flask via inline filtration. Filtered hydrogen chloride in IPA is then added to reform the salt, which is isolated via filtration. The filtercake is washed with IPA and then dried to give 926 g of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride as a slightly off-white solid.

An XRPD of the product is shown in FIG. 35 and is consistent with Crystalline Form A. The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640d) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short anti-scatter extension, and an anti-scatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. The diffraction pattern is collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 717 s, Scan Speed: 3.3°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

FIG. 36 overlays the XRPD patterns from FIG. 1 and FIG. 35. There are some differences in relative peak intensities that are likely due to preferred orientation (PO). PO is the tendency for crystals, usually plates or needles, to pack against each other with some degree of order. PO can affect peak intensities, but not peak positions, in XRPD patterns.

An XRPD of the product after long-term storage is shown in FIG. 37 and is consistent with Crystalline Form A. The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640e) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short antiscatter extension, and antiscatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. The diffraction pattern is collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 719 s, Scan Speed: 3.3°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

One PANalytical pattern is analyzed for Crystalline Form A, and preferred orientation and particle statistic effects are assessed through comparison with additional XRPD patterns analyzed using alternate geometry in addition to a calculated XRPD pattern from single crystal analysis. An indexing result for the XRPD shown in FIG. 37 collected with Cu Kα radiation is shown in FIG. 38. The XRPD pattern is indexed using X'Pert High Score Plus 2.2a (2.2.1). Observed peaks are shown in FIG. 39 and listed in Table C in formula 1.32 above, representative peaks are listed in Table B in formula 1.25 above, and characteristic peaks are listed in Table A in formula 1.16 above.

Example 6—Preparation of Crystals of Form B Example 6a

558.9 mg of Crystalline Form A from Example 5 above is slurried in 5 mL dichloromethane. The preparation is stirred (300 RPM) in a sealed vial at ambient temperature for 16 days. White solids are isolated by vacuum filtration, rinsed with 1 mL of dichloromethane, and briefly dried under nitrogen. Product is Crystalline Form A. An XRPD pattern of the product is in FIG. 47. The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640e) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short antiscatter extension, and an antiscatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. Diffraction patterns are collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 720 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

Example 6b

34.3 mg of Crystalline Form A from Example 6a is contacted with 1 mL of water. The sample is sonicated until solids dissolve. The sample is capped and left at ambient temperature until nucleation is observed, within one day. Singles are isolated from the bulk sample for analysis.

Data Collection: A colorless plate of C₁₅H₁₆ClN [C₁₅H₁₆N, Cl], having approximate dimensions of 0.31×0.21×0.09 mm, is mounted on a nylon loop in random orientation. Preliminary examination and data collection are performed with Cu Kα radiation (λ=1.54178 Å) on a Rigaku Rapid II diffractometer equipped with confocal optics. Refinements are performed using SHELX2014 (Sheldrick, G. M. Acta Cryst. 2015, C71, 3-8). Cell constants and an orientation matrix for data collection are obtained from least-squares refinement using the setting angles of 22958 reflections in the range 2°<θ<26°. From the systematic presence of the following conditions: h00 h=2n; 0k0 k=2n; 00l l=2n, and from subsequent least-squares refinement, the space group is determined to be P2₁2₁2₁ (no. 19). The data are collected to a maximum diffraction angle (2θ) of 144.79°, at a temperature of 100 K.

Data Reduction: Frames are integrated with HKL3000 (Otwinowski, Z.; Minor, W. Methods Enzymol. 1997, 276, 307). A total of 22958 reflections are collected, of which 2415 are unique. Lorentz and polarization corrections are applied to the data. The linear absorption coefficient is 2.422 mm⁻¹ for Cu Kα radiation. An empirical absorption correction using SCALEPACK (Otwinowski, Z.; Minor, W. Methods Enzymol. 1997, 276, 307) is applied. Transmission coefficients range from 0.753 to 0.976. A secondary extinction correction is applied (Sheldrick, G. M. Acta Cryst. 2015, C71, 3-8). The final coefficient, refined in least-squares, is 0.0055(8) (in absolute units). Intensities of equivalent reflections are averaged. The agreement factor for the averaging is 4.95% based on intensity.

Structure Solution and Refinement: The structure is solved by direct methods using SHELXS-97 (Sheldrick, G. M. Acta Cryst. 2015, C71, 3-8). The remaining atoms are located in succeeding difference Fourier syntheses. Hydrogen atoms are included in the refinement but restrained to ride on the atom to which they are bonded. The structure is refined in full-matrix least-squares by minimizing the function:

Σw(|F _(o)|² −|F _(c)|²)²

The weight w is defined as 1/[σ²(F_(o) ²)+(0.0437P)²+(2.1802P)], where P=(F_(o) ²+2F_(c) ²)/3. Scattering factors are taken from the “International Tables for Crystallography” (International Tables for Crystallography, Vol. C, Kluwer Academic Publishers: Dordrecht, the Netherlands, 1992, Tables 4.2.6.8 and 6.1.1.4). Of the 2415 reflections used in the refinements, only the reflections with F_(o) ²>2σ(F_(o) ²) are used in calculating the fit residual, R. A total of 2372 reflections are used in the calculation. The final cycle of refinement includes 155 variable parameters and converges with unweighted and weighted agreement factors of:

R=Σ|F _(o) −F _(c) |/ΣF _(o)=0.0453

R _(w)=√{square root over ((Σw(F _(o) ² −F _(c) ²)² /Σw(F _(o) ²)²))}=0.1224

The standard deviation of an observation of unit weight (goodness of fit) is 1.150. The highest peak in the final difference Fourier has a height of 0.318 e/Å³. The minimum negative peak has a height of −0.313 e/Å³.

Calculated X-ray Powder Diffraction (XRPD) Pattern: A calculated XRPD pattern is generated for Cu radiation using Mercury (Macrae, C. F.; Edgington, P. R.; McCabe, P.; Pidcock, E.; Shields, G. P.; Taylor, R.; Towler, M.; and van de Streek, J., J. Appl. Cryst., 2006, 39, 453-457) and the atomic coordinates, space group, and unit cell parameters from the single crystal structure. Because the single crystal data are collected at low temperatures (100 K), peak shifts may be evident between the pattern calculated from low temperature data and the room temperature experimental powder diffraction pattern, particularly at high diffraction angles. The calculated XRPD pattern is adjusted to room temperature using the previously obtained unit cell parameters from XRPD indexing.

Atomic Displacement Ellipsoid and Packing Diagrams: The atomic displacement ellipsoid diagram is prepared using Mercury (Macrae, C. F.; Edgington, P. R.; McCabe, P.; Pidcock, E.; Shields, G. P.; Taylor, R.; Towler, M.; and van de Streek, J., J. Appl. Cryst., 2006, 39, 453-457). Atoms are represented by 50% probability anisotropic thermal ellipsoids. Packing diagrams and additional figures are prepared using Mercury. Hydrogen bonding is represented as dashed lines. Assessment of chiral centers is performed with PLATON (Spek, A. L. PLATON. Molecular Graphics Program. Utrecht University, Utrecht, The Netherlands, 2008. Spek, A. L., J. Appl. Cryst. 2003, 36, 7). Absolute configuration is evaluated using the specification of molecular chirality rules (Cahn, R. S.; Ingold, C; Prelog, V. Angew. Chem. Intern. Ed. Eng., 1966, 5, 385 and Prelog, V., Helmchen, G. Angew. Chem. Intern. Ed. Eng., 1982, 21, 567).

Results: The orthorhombic cell parameters and calculated volume are: a=5.9055(2) A, b=7.4645(3) A, c=29.1139(13) A (α=β=γ=90°), V=1283.39(9) Å³. The formula weight of the asymmetric unit in Crystalline Form B is 245.74 g mol⁻¹ with Z=4, resulting in a calculated density of 1.272 g cm⁻³. The space group is determined to be P2₁ 2 ₁ 2 ₁ (no. 19). A summary of the crystal data and crystallographic data collection parameters are provided in Table 15 below. The space group and unit cell parameters are consistent with those obtained for Form B by XRPD indexing.

The R value is 0.0453 (4.53%).

An atomic displacement ellipsoid drawing of Crystalline Form B is shown in FIG. 24.

The asymmetric unit shown in FIG. 24 contains one protonated (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane molecule and one chloride counter ion.

Packing diagrams viewed along the a, b, and c crystallographic axes are shown in FIGS. 25-27, respectively. Hydrogen bonding occurs from the amine to the chloride, forming one-dimensional hydrogen bonded helical chains along the a axis, shown in FIG. 28.

The molecular conformation of the (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane molecules in the structure of Crystalline Form B is compared with the molecular conformation observed in the structure of Crystalline Form A in FIG. 29, and the packing of the two forms viewed along the a axis is compared in FIG. 30. The hydrogen bonding in the structures of Crystalline Forms A and B is shown in FIG. 31. Adjacent molecules are linked through chloride ions in the Crystalline Form A hydrogen bonding forming straight chains down the a axis. The amine groups of adjacent molecules are too far apart in the Crystalline Form B packing to be linked in a similar manner, and instead the hydrogen bonding in Crystalline Form B forms a helical chain.

The absolute structure can be determined through an analysis of anomalous X-ray scattering by the crystal. A refined parameter x, known as the Flack parameter (Flack, H. D.; Bernardinelli, G., Acta Cryst. 1999, A55, 908; Flack, H. D., Bernardinelli, G., J. Appl. Cryst. 2000, 33, 1143, Flack, H. D., Acta Cryst. 1983, A39, 876; Parsons, S.; Flack, H. D.; Wagner, T., Acta Cryst. 2013, B69, 249-259), encodes the relative abundance of the two components in an inversion twin. The structure contains a fraction 1−x of the model being refined, and x of its inverse. Provided that a low standard uncertainty is obtained, the Flack parameter should be close to 0 if the solved structure is correct, and close to 1 if the inverse model is correct. The measured Flack parameter for the structure of Crystalline Form B shown in FIG. 24 is 0.010 with a standard uncertainty of 0.010, which indicates strong inversion-distinguishing power. The compound is enantiopure and the absolute configuration can be assigned directly from the crystal structure.

Refinement of the Flack parameter (x) does not result in a quantitative statement about the absolute structure assignment. However, an approach applying Bayesian statistics to Bijvoet differences can provide a series of probabilities for different hypotheses of the absolute structure (Hooft, R. W. W.; Strayer, L. H.; and Spek, A. L., J. Appl. Cryst., 2008, 41, 96-103 and Bijvoet, J. M.; Peerdeman, A. F.; van Bommel, A. J., Nature, 1951, 168, 271). This analysis provides a Flack equivalent (Hooft) parameter in addition to probabilities that the absolute structure is either correct, incorrect or a racemic twin. For the current data set the Flack equivalent (Hooft) parameter is determined to be −0.001(7), the probability that the structure is correct is 1.000, the probability that the structure is incorrect is 0.000 and the probability that the material is a racemic twin is 0.000.

This structure contains two chiral centers located at C2 and C3 (refer to FIG. 24), which bond in the S and R configuration, respectively.

FIG. 32 shows a calculated XRPD pattern of Crystalline Form B, generated from the single crystal structure.

An experimental XRPD pattern of Crystalline Form B is shown in FIG. 33 (same as XRPD pattern in FIG. 40, Example 8), overlaid with the calculated pattern and a calculated pattern that has been adjusted to room temperature. All peaks in the experimental patterns are represented in the calculated XRPD pattern, indicating a single phase.

Differences in intensities between the calculated and experimental powder diffraction patterns often are due to preferred orientation. Preferred orientation is the tendency for crystals to align themselves with some degree of order. This preferred orientation of the sample can significantly affect peak intensities, but not peak positions, in the experimental powder diffraction pattern. Furthermore, some shift in peak position between the calculated and experimental powder diffraction patterns may be expected because the experimental powder pattern is collected at ambient temperature and the single crystal data are collected at 100 K. Low temperatures are used in single crystal analysis to improve the quality of the structure but can contract the crystal resulting in a change in the unit cell parameters, which is reflected in the calculated powder diffraction pattern. These shifts are particularly evident at high diffraction angles. The calculated XRPD pattern has been adjusted to room temperature using the unit cell obtained previously from XRPD indexing.

TABLE 15 Crystal Data and Data Collection Parameters for (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride Form B (Crystalline Form B) Empirical formula C₁₅H₁₆ClN Formula weight 245.74 Temperature 100(2) K Wavelength 1.54178 Å Crystal system Orthorhombic Space group P2₁2₁2₁ Unit cell dimensions a = 5.9055(2) Å α = 90°. b = 7.4645(3) Å β = 90°. c = 29.1139(13) Å γ = 90°. Volume 1283.39(9) Å³ Z 4 Density (calculated) 1.272 Mg/m³ Absorption coefficient 2.422 mm⁻¹ F(000) 520 Crystal size 0.310 × 0.210 × 0.090 mm³ Theta range for data 6.080 to 72.393°. collection Index ranges −7 <= h <= 7, −8 <= k <= 8, −35 <= l <= 35 Reflections collected 22958 Independent reflections 2415 [R(int) = 0.0495] Completeness to theta = 98.5% 67.679° Absorption correction Semi-empirical from equivalents Max. and min. transmission 0.976 and 0.753 Refinement method Full-matrix least-squares on F² Data/restraints/parameters 2415/0/155 Goodness-of-fit on F² 1.150 Final R indices [I > R1 = 0.0453, wR2 = 0.1224 2sigma(I)] R indices (all data) R1 = 0.0464, wR2 = 0.1240 Absolute structure Flack parameter: 0.010(10) parameter Hooft parameter: −0.001(7) Extinction coefficient 0.0055(8) Largest diff. peak and hole 0.318 and −0.313 e.Å⁻³

Example 7—Preparation of Crystalline Form B

470.9 mg of Crystalline Form A from Example 5 above is mixed with 5 mL of water in a 20 mL glass vial. The slurry is stirred at ambient temperature for 16 days with a stir bar to allow conversion to occur. The solids are collected by vacuum filtration and briefly dried under nitrogen.

Example 8—Preparation of Crystalline Form B

1 g of the product from Example 16 below is stirred in 5 mL of Special Industrial 200 (ethanol denatured) over weekend at ambient temperature. The mixture is filtered and rinsed with 2 mL of Special Industrial 200 (ethanol denatured) and followed by isopropyl acetate (2×3 mL). Pull dry the solids over 2 hours and then dry at 40° C. over 6 hours to give 0.81 g of product.

An XRPD shows the product is Crystalline Form B (FIG. 40 and also shown as the top XRPD pattern in FIG. 33). The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640d) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short anti-scatter extension, and an anti-scatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. The diffraction pattern is collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.01-39.98° 2θ, Step Size: 0.017° 2θ, Collection Time: 720 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

One PANalytical pattern is analyzed for this material, and preferred orientation and particle statistic effects are assessed through comparison with additional XRPD patterns analyzed using alternate geometry in addition to a calculated XRPD pattern from single crystal analysis. An indexing result for the XRPD shown in FIG. 40 collected with Cu Kα radiation is shown in FIG. 41. The XRPD pattern is indexed using X'Pert High Score Plus 2.2a (2.2.1). Observed peaks are shown in FIG. 42 and listed in Table F in formula 1.109, representative peaks are listed in Table E in formula 1.102, and characteristic peaks are listed in Table D in formula 1.93.

Example 9—Crystalline Form C

A turbid solution containing 458.2 mg of Crystalline Form A from Example 5 and 40 mL of IPA is generated at elevated temperature. The hot solution is filtered with a 0.2-μm nylon filter into a clean vial and placed into a freezer. After two days, the solids are recovered by vacuum filtration and briefly dried under nitrogen. The solids are identified as a mixture of Crystalline Forms A and C. A slurry is generated with 42.2 mg of the mixture and 0.8 mL of a saturated DCM solution. (The saturated solution is generated with 65.4 mg of Crystalline Form A from Example 5 in 5 mL of DCM at ambient temperature. Excess solids are filtered from the solution the following day with a 0.2-μm nylon filter.) The slurry is stirred, 100 RPM, with an agate ball at 2° C. for 3 weeks to allow conversion to occur. Solids isolated from the resulting suspension through vacuum filtration are stored at a temperatures between −25 and −10° C.

An XRPD of the product is shown in FIG. 43. The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640d) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short anti-scatter extension, and an anti-scatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. The diffraction pattern is collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 720 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

One PANalytical pattern is analyzed for this material, and preferred orientation and particle statistic effects are assessed through comparison with additional XRPD patterns analyzed using alternate geometry. An indexing result for the XRPD pattern shown in FIG. 43 collected with Cu Kα radiation is shown in FIG. 44. The XRPD pattern is indexed using proprietary software (U.S. Pat. No. 8,576,985). Observed peaks are shown in FIG. 45 and listed in Table I in formula 1.183, representative peaks are listed in Table H in formula 1.176, and characteristic peaks are listed in Table G in formula 1.168.

Example 10—Interconversion Slurry Experiments

An Energy-Temperature Diagram is a semi-quantitative graphical solution of the Gibbs-Helmholtz equation, where the enthalpy (H) and free energy (G) isobars for each form are depicted as a function of temperature. The graph assumes that the free energy isobars intersect at most once and, second, that the enthalpy isobars of the polymorphs do not intersect. The melting point of a polymorph is defined as the temperature at which the free energy isobar of the polymorph intersects the free energy isobar of the liquid. The transition temperature is defined as the temperature at which the free energy isobar of one polymorph intersects the free energy isobar of the second. Thus, at T_(t) both polymorphs have equal free energy, and consequently are in equilibrium with each other.

The proposed Energy-Temperature Diagram for Crystalline Forms A, B, and C is shown in FIG. 46. In the diagram, the enthalpy (H) and free energy (G) isobars for each form are depicted as a function of temperature (T). Subscripts A, B, C, and L refer to Crystalline Forms A, B, C, and liquid phase, respectively. Subscripts f, t, and m refer to fusion, transition point, and melting point, respectively. The graph assumes that the free energy isobars intersect at most once and, second, that the enthalpy isobars of the polymorphs do not intersect. The melting point of a polymorph is defined as the temperature at which the free energy isobar of the polymorph intersects the free energy isobar of the liquid. The transition temperature is defined as the temperature at which the free energy isobar of one polymorph intersects the free energy isobar of the second. Thus, at T_(t) both polymorphic forms have equal free energy, and consequently are in equilibrium with each other. Crystalline Form C is the stable solid phase below T_(t,C→B) (because the free energy of Crystalline Form C is lower than that of Crystalline Form B), Crystalline Form B is the stable solid phase between T_(t,C→B) and T_(t,B→A), and Crystalline Form A is the stable solid phase above T_(t,B→A). The low energy polymorph will have a lower fugacity, vapor pressure, thermodynamic activity, solubility, dissolution rate per unit surface area, and rate of reaction relative to the other polymorphs.

Interconversion experiments are performed to test the hypothetical thermodynamic relationship between materials illustrated by the Energy-Temperature Diagram above. Interconversion or competitive slurry experiments are a solution-mediated process that provides a pathway for the less soluble (more stable) crystal to grow at the expense of the more soluble crystal form (Bernstein, J. Polymorphism in Molecular Crystals. Clarendon Press, Oxford, 2006; Brittain, H. G., Polymorphism in Pharmaceutical Solids. Marcel Dekker, Inc., New York, 1999). Outside the formation of a solvate or degradation, the resulting more stable polymorph from an interconversion experiment is independent of the solvent used because the more thermodynamically stable polymorph has a lower energy and therefore lower solubility. The choice of solvent affects the kinetics of polymorph conversion and not the thermodynamic relationship between polymorphic forms (Gu, C. H., Young, V. Jr., Grant, D. J., J. Pharm. Sci. 2001, 90 (11), 1878-1890).

Binary interconversion slurry experiments between Crystalline Forms A, B, and C in different solvent systems at temperatures spanning approximately 2 through 67° C. are summarized in Table 16 below. Saturated solutions are generated and then added to mixtures composed of approximately equivalent quantities of two of the polymorphs. The samples are slurried from overnight to three weeks and the solids harvested and analyzed by XRPD. The results of the interconversion studies indicate that the relative thermodynamic stability of the enantiotropes Crystalline Forms A, B, and C are correctly depicted by the proposed Energy-Temperature Diagram. In addition, T_(t,C→B) is expected below 2° C. (is not determined), T_(t,C→A) will be between 2° C. and ambient temperature, and T_(t,B→A) will be between 37 and 54° C.

TABLE 16 Binary Interconversion Slurries between Crystalline Forms A, B, and C Crystalline Forms Results Temp¹ Duration¹ Solvent (v/v) B + A B 2° C. 3 weeks DCM B 2° C. 3 weeks EtOH B + C B 2° C. 3 weeks DCM B 2° C. 3 weeks EtOH C + A C 2° C. 3 weeks DCM  C + A↓² 2° C. 3 weeks EtOH B + A B ambient 2 weeks DCM B ambient 2 weeks EtOH B ambient 2 weeks 10:1 ACN/H₂O B + C B ambient 2 weeks DCM B ambient 2 weeks EtOH B ambient 2 weeks 10:1 ACN/H₂O A + C A ambient 2 weeks DCM A ambient 2 weeks EtOH  B³ ambient 2 weeks 10:1 ACN/H₂O B + A B 37° C. 4 days DCM A + B A 54° C. 3 days EtOH A + B A + B↓² 67° C. overnight EtOH A 67° C. 4 days EtOH B + C A³ + B   67° C. overnight EtOH A + C A 67° C. overnight EtOH ¹Duration and temperatures are approximate. ²Downward arrow indicates the peak intensities of the associated crystalline phase have decreased relative to those of the starting mixture. The length of time of the experiment is not sufficient to reach equilibrium; nevertheless, conclusions of the predominant form can be made based on the resulting mixture. ³The solution-mediated interconversion process provides a pathway for the less soluble (more stable relative to the other) crystal to grow at the expense of the more soluble crystal form. However, when neither of the forms involved in the binary competitive slurry is the most thermodynamically stable form, the possibility of the most stable crystal to grow at the expense of the other two more soluble crystal forms can also result. This solvent-mediated polymorphic transformation is controlled by its nucleation rate, which is generally higher in a solvent giving higher solubility. In addition to the solubility, the strength of the solvent-solute interactions is also important. Degree of agitation and temperature also change the polymorphic transformation rate by influencing the crystallization kinetics of the more stable polymorph.

Crystalline Form B exhibits a lower apparent solubility than Crystalline Form A in both methanol and water (Table 17 below). Solution calorimetry (SolCal) analyses are also performed to determine the heats of solution in methanol at 25° C. and confirm the stable form at this temperature (see Example 15). Based on SolCal data, the dissolutions of both Crystalline Forms A and B in methanol are endothermic events with average heats of solution of 48.618 and 64.567 J/g, respectively, indicating that Crystalline Form B is more stable than Crystalline A at 25° C.

Experimental: Approximate Solubility

A weighed sample is treated with aliquots of the test solvent at room temperature. The mixture is sonicated between additions to facilitate dissolution. Complete dissolution of the test material is determined by visual inspection. Solubility is estimated based on the total solvent used to provide complete dissolution. The actual solubility may be greater than the value calculated because of the use of solvent aliquots that are too large or due to a slow rate of dissolution.

TABLE 17 Approximate Solubility of Crystalline Forms A and B Crystalline Form Solvent Solubility (mg/mL) A MeOH 74 B MeOH 63 A H₂O  34¹ B H₂O  21² ¹Nucleation observed after one day. A single crystal of Crystalline Form B is isolated. ²Nucleation of irregular fines with no birefringence observed after 7 days.

Example 11—Accelerated Stress Conditions

Crystalline Forms A, B, and C are exposed to accelerated stress conditions for two weeks (Table 18 below). Based on XRPD, Crystalline Forms A and B remain unchanged at 30° C./56% RH or 40° C./75% RH within the time frame evaluated. However, Crystalline Form C converts to a mixture of Crystalline Forms A and B within two weeks at 40° C./75% RH. Crystalline Form C is metastable at this condition. For Crystalline Form A, in the absence of seeds of the more stable polymorph, the critical free energy barrier for the nucleation of Crystalline Form B is not overcome in the solid state or in solvent mediated form conversion experiments within the time frame evaluated.

TABLE 18 Accelerated Stability Evaluation of Crystalline Form Results Crystalline (Crystalline Form Condition Time Form) A source sample — A subsample stored in freezer T zero — 30° C./60% RH 2 weeks A 40° C./75% RH 2 weeks A B source sample — B subsample stored in freezer T zero — 30° C./60% RH 2 weeks B 40° C./75% RH 2 weeks B C source sample — C subsample stored in freezer T zero — 40° C./75% RH 2 weeks A + B

T_(t,B→A) is between 37 and 54° C. A mixture of Forms A and B (combination of portions 1 and 2 from Example 17), completely converts to Form A upon exposure to 230° C. (Table 19 below).

Experimental: Relative Humidity Stress

The following relative humidity jars (saturated salt solutions are used to generate desired relative humidity) are utilized: 75% RH (NaCl) and 56% RH (NaBr) (Nyqvist, H., Int. J. Pharm. Tech. & Prod. Mfr. 1983, 4 (2), 47-48).

TABLE 19 Physical Stability of Mixture of Forms A and B Method¹ Observation² Results expose to 230° C., sublimation is observed; A moist pH paper held in no pH change is noted, suggesting head space above sample no loss of HCl upon heating; fines and large blades, B ¹Time and temperature are approximate. ²B = birefringent when observed by polarized light microscopy ³ Upward arrow indicates the peak intensities of the associated crystalline phase have increased relative to those of the starting mixture.

Example 12—Preparation of Crystalline Form B

A portion of Crystalline Form A from Example 5 above is slurried with water at ambient temperature for 16 days. Crystalline Form B is isolated. An XRPD of the product is in FIG. 48. The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640e) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short antiscatter extension, and an antiscatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. Diffraction patterns are collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 716 s, Scan Speed: 3.3°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

Example 13—XRPD of Mixture of Crystalline Form A and Minor Quantity of Crystalline Form B

An XRPD pattern of a mixture of Crystalline Form A and a minor quantity of Crystalline Form B product is in FIG. 49 (Example 17 for synthesis). The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640e) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short antiscatter extension, and an antiscatter knife edge are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. Diffraction patterns are collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b. Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 720 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

Example 14—Solution Calorimetry (SolCal) Analyses of Crystalline Forms A and B

Solution calorimetry analysis for each form is measured in triplicate in methanol and the data are summarized in Table 21. For each test, two heats of solution are obtained—one calculated using a calibration preceding the sample analysis and one calculated using a calibration following the sample analysis. The mean values from the two calibrations are also provided in the table. Clear solutions are observed after each test.

The dissolutions of both Crystalline Forms A and B in methanol are endothermic events with average heats of solution are 48.618 and 64.567 J/g, respectively. The standard deviation for each set is 0.457 and 0.344 J/g, respectively.

Crystalline Form B has a higher heat of solution value than Form A, indicating Crystalline Form B is more stable than A at 25° C. The enthalpy of the transition calculated from the SolCal data from Form B to Form A is about 15.9 J/g. The difference in the heat of fusion in the solid-state transition in the DSC of Crystalline Form B is 15.9 J/g (see FIGS. 8 and 55), which is in good agreement with the SolCal results.

Solution calorimetry is performed using a Thermometric 2225 Precision Solution Calorimeter, a semi-adiabatic calorimeter. Solution Calorimeter System v.1.2 software is used. Samples are weighed into glass crushing ampoules and are sealed using silicone rubber plugs and hot wax. Experiments are carried out in 100 mL of methanol at 25° C. The measurement of the heats of solution of the samples is both preceded and followed by calibrations using an internal heater. The heats of solution are calculated using dynamic of calibration model.

TABLE 21 Heats of Solution of Crystalline Forms A and B in Methanol ΔH₁, ΔH₂, ΔH_(mean), Sample Replicate J/g^((a)) J/g^((b)) J/g Observation^((c)) Crystalline 1 (52.540 mg Crystalline 46.050 50.168 48.109 clear solution Form A Form A, stirrer 500 rpm) 2 (55.427 mg Crystalline 48.293 49.217 48.755 clear solution Form A, stirrer 500 rpm) 3 (49.393 mg Crystalline 48.077 49.905 48.991 clear solution Form A, stirrer 500 rpm) average, J/g 48.618 — standard deviation 0.457 — Crystalline 1 (56.730 mg Crystalline 64.004 64.985 64.495 clear solution Form B Form A, stirrer 500 rpm) 2 (49.276 mg Crystalline 63.471 65.057 64.264 clear solution Form A, stirrer 500 rpm) 3 (51.723 mg Crystalline 64.461 65.421 64.941 clear solution Form A, stirrer 500 rpm) average, J/g 64.567 — standard deviation 0.344 — ^((a))Calculated using the calibration before breaking the sample vial. ^((b))Calculated using the calibration after breaking the sample vial. ^((c))Observations are made at the time when tests are completed.

Example 15—Hot Stage Microscropy (HSM) of Crystalline Form A from Example 1

Hot stage microscopy is performed using a Linkam hot stage (model FTIR 600) mounted on a Leica DM LP microscope. Samples are observed using a 20× objective (obj.). Samples are placed on a coverslip, and a second coverslip is then placed over the sample. Each sample is visually observed as the stage is heated. Images are captured using a SPOT Insight™ color digital camera with SPOT Software v. 4.5.9. The hot stage is calibrated using USP melting point standards.

By HSM of Crystalline Form A, between 182 and 239° C., the smallest particles evaporate and the resulting vapor recrystallizes into larger crystals. Condensation and melt are observed between 239 and 247° C.; the needles appear to melt last consistent with the multiple endotherms observed by DSC. Two preparations are utilized for the analysis. For the first, discoloration (decomposition) is observed after melt. For the second, rapid cooling results in recrystallization of the melt.

Example 16—Preparation of Mixture of Crystalline Forms A and B

Commercially available reagents are used as received unless otherwise noted. Reactions requiring inert atmospheres are run under nitrogen unless otherwise noted.

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction 2-naphthylacetonitrile 167.21 NA 1.0 mol eq (SM)   50 Kg/299.03 mol (S)-(+)-epichlorohydrin 92.52 3.12 1.12 mol eq 31.0 Kg/334.9 mol tetrahydrofuran 72.11 0.889 5.0 ml/g SM 250 L 2M sodium bis(trimethylsilyl)amide  2.0M 0.916 2 mol eq  299 L/598.0 mol in THF borane-dimethylsulfide 10.0M 0.80 2.5 mol eq 89.7 L/897.0 mol Isolation 2M HCl (aqueous)   2M NA 11.5 ml/g SM 650 L isopropyl acetate 102.13 0.872 4 mL/g SM as required water 18.02 1.00 5 mL/g SM as required ammonia (aqueous) NA 0.889 2.0 mL/g SM 100 L methylene chloride 60 1.325 4 × 5 mL/g SM as required 2-methyltetrahydrofuran 86.13 0.86 12.6 mL/g SM as required para-toluenesulfonic acid 190.22 NA 0.953 mol eq. 54.2 Kg/284.9 mol monohydrate

Steps 1 and 2

2-naphthylacetonitrile (50 Kg) is dissolved in THF (250 L), 32 kg of (S)-(+)-epichlorohydrin is added and the solution cooled to −10° C. A 2.0 M solution of sodium hexamethyldisilylazane in THF (299 L) is then added keeping the internal temperature below −10° C. This addition requires 14 hrs., 14 minutes to complete. The reaction mixture is then stirred an additional four hours at approximately −10° C., after which a sample of the reaction mixture is analyzed by HPLC. While keeping the internal temperature less than 0° C., borane dimethylsulfide (71 kg) is added over four hours and 33 minutes. After completion of the borane addition the reaction mixture is slowly heated to 60° C. to reduce the nitrile to the amine. During this heat-up, an exotherm is noted, which initiates at 45° C. After heating at 60° C. for 14 hours and 46 minutes, a sample of the reaction mixture is analyzed by HPLC.

The reaction mixture is then cooled to 24° C. and transferred to a solution of 2M HCl over 2 hours and 28 minutes and the reactor is rinsed with THF (22.3 Kg) and transferred to the HCl containing reaction mixture. The two phase mixture is heated to 45° C. to 55° C. and stirred for 1 hour 48 minutes at this temperature followed by cooling to 30° C. The pH of the quenched reaction mixture is measured and found to be 1. Reaction workup continues by addition of IPAc, stir, and separate the layers. Charge 1 M HCl solution to the organic layer, stir, separate the layers, and discard the organic layer. Aqueous ammonia is added to the combined aqueous layer and the pH measured which shows a pH of 9. Workup then continues by extraction with two extractions of the aqueous layer with IPAc. The combined organic extracts are then washed with 5% sodium chloride solution. The resulting organic layer is partially concentrated to azeotropically dry and co-evaporation with methylene chloride four times and followed by dilution with methylene chloride and transfer of the reaction mixture via in-line filter to clean, dry reactor and diluting with IPAc. p-Toluenesulfonic acid hydrate (54 Kg) is then added in portions to precipitate the desired product as its pTsOH salt and the reaction suspension is stirred over three hours at 10° C. to 15° C. and the product is isolated by filtration. The filter cake is washed with 2-methyltetrahydrofuran and followed by IPAc then pull dried over two hours. The crude product is purified by stirring with 2-methyltetrahydrofuran over 11 hours 36 minutes at 10° C. to 15° C. and the product is isolated by filtration. The filtered solid is washed with 2-methyltetrahydrofuran and then dried to a constant weight to give 73.8 Kg of the desired product as a white solid. Yield=73.8 Kg (62%). HPLC=96.8%.

Steps 3 and 4

MW d Compound (g/mol) (g/mL) Equivalents Amt/mol Reaction 2-naphthylcyclopropylamine-tosylate 399.51 NA 1.0 mol eq 73.8 Kg/184.7 mol salt 2-methyltetrahydrofuran 86.13 0.86  10 mL/g SM as required isopropylacetate 102.13 0.872 as required as required thionyl chloride 118.97 1.638 1.2 eq 26.4 Kg/221.9 mol sodium hydroxide, 50% aqueous 40 1.548 11 mol eq 165.3 Kg Isolation water 18.02 1.00  10 mL/g SM as required magnesium sulfate NA NA 0.5 g/g 36.5 Kg hydrogen chloride in isopropyl alcohol 5.7M NA 1.0 mol eq 33.6 L Ethyl alcohol 200 (Special Industrial 80.25 0.786 14 mL/g SM as required denatured)

The amine-pTsOH salt (73.8 Kg) obtained from step 2 above is suspended in 2-methyltetrahydrofuran (738 L) to give a slurry. Thionyl chloride (26.4 kg) is then added over three hours. Upon completion of the thionyl chloride addition, the reaction mixture is stirred three additional hours. Aqueous sodium hydroxide (5M, 10 mol equivalents) is added over three hours followed by two hours of additional stirring. The layers are allowed to settle and the pH of the aqueous layer is checked and found to be 9. Water (2 mL/g, SM) is added, the reaction mixture is stirred 15 more minutes at room temperature, and the layers are separated and the organic layer washed twice with water. The aqueous layers are combined and back extracted with 2-methyltetrahydrofuran and the initial organic layer and the back extract combined. These combined organic layers are washed with brine, dried over magnesium sulfate, and partially concentrated. After concentration, hydrogen chloride in IPA (1.0 mol equivalent of HCl in IPA) is added and stirred 2 hours to form the crude salt which is isolated by filtration, washed with 2-methyltetrahydrofuran and followed by IPAc and then pull dried over 2 hours under vacuum.

The crude product (82.6 Kg) obtained from above is dissolved in 14 volumes of hot ethanol (70° C.) and then filtered via an encapsulated carbon filter to improve the color. The dissolution vessel and the encapsulated carbon filter and transfer line are then rinsed with additional hot ethanol (70° C.) and the rinse combined with the filtrate. The combined filtrate and washes are partially concentrated in vacuo to approximately 5 total volumes (relative to crude product input) and then stirred over two hours at 0° C. The resulting solids are isolated by filtration, the filter cake washed with cooled (0° C. to 5° C.) ethanol and followed by IPAc and the washed solids then dried to give 33.6 Kg of the product as a slightly off-white solid. Yield=33.6 Kg (73% yield). Achiral HPLC=98%.

The material is then dried via cone drying. After drying, the material is sieved.

A portion of the material (14 Kg) is then dissolved in 15 volumes of hot ethanol (70° C.) and filtered via an encapsulated carbon filter to improve the color. The dissolution vessel and the encapsulated carbon filter and transfer line are then rinsed with additional hot ethanol (70° C.) and the rinse combined with the filtrate. The combined filtrate and washes are partially concentrated in vacuo to approximately 8 total volumes (relative to starting 14 Kg of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride input) and then stirred over two hours at 18° C. The resulting solids are isolated by filtration, the filter cake washed with cooled (5° C. to 10° C.) ethanol and followed by IPAc and the washed solids then dried to give 9.4 Kg (67.1% of yield) of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride as a white solid. Achiral HPLC=98%.

An XRPD of the product is shown in FIG. 56. The XRPD is consistent with Crystalline Form A with evidence of lower intensity peaks at 18.9°, 19.2°, 23.6°, 23.8°, 28.2°, and 28.7° 2θ attributed to Crystalline Form B. The XRPD pattern is collected with a PANalytical X'Pert PRO MPD diffractometer using an incident beam of Cu radiation produced using an Optix long, fine-focus source. An elliptically graded multilayer mirror is used to focus Cu Kα X-rays through the specimen and onto the detector. Prior to the analysis, a silicon specimen (NIST SRM 640e) is analyzed to verify the observed position of the Si 111 peak is consistent with the NIST-certified position. A specimen of the sample is sandwiched between 3-μm-thick films and analyzed in transmission geometry. A beam-stop, short antiscatter extension, antiscatter knife edge, are used to minimize the background generated by air. Soller slits for the incident and diffracted beams are used to minimize broadening from axial divergence. Diffraction patterns are collected using a scanning position-sensitive detector (X'Celerator) located 240 mm from the specimen and Data Collector software v. 2.2b.

XRPD Data acquisition parameters are: Panalytical X-Pert Pro MPD PW3040 Pro, X-ray Tube: Cu (1.54059 Å), Voltage: 45 kV, Amperage: 40 mA, Scan Range: 1.00-39.99° 2θ, Step Size: 0.017° 2θ, Collection Time: 721 s, Scan Speed: 3.2°/min., Slit: DS: ½°, SS: null, Revolution Time: 1.0 s, Mode: Transmission.

Example 17—Preparation of Mixture of Crystalline Forms A and B

To a 2 L 3 neck round bottom flask with mechanical stirring, reflux condenser, nitrogen inlet, thermocouple, and heating mantle, is added 50 g of the product from Example 16 above and EtOH Special Industrial (750 mL, 15 vol). The mixture is heated to reflux (77° C.). Solids dissolve forming clear solution at 72° C. Loose charcoal slurry is added (5 g, 0.1 eq in 100 mL EtOH) and the mixture is stirred for 1 hour. Filter and rinse with hot EtOH (150 mL). Split filtrate into two equal portions.

Portion 1

Concentrate down to 10 vol (250 mL) at 50° C. Small amount of solids start to precipitate during concentration. Transfer to 500 mL 3 neck round bottom flask with mechanical stirring and allow to cool to room temp. Stir for 2 hours at room temp. Suspension forms. Filter and rinse with EtOH (50 mL, 2 vol) followed by IPAc (50 mL). Pull dry on filter. Yield=20.5 g (82%).

Portion 2

Concentrate down to 7 vol (175 mL) at 50° C. Small amount of solids start to precipitate during concentration. Transfer to 500 mL 3 neck round bottom flask with mechanical stirring and allow to cool to room temp. Stir for 2 hours at room temp. Suspension forms. Filter and rinse with EtOH (50 mL, 2 vol) followed by IPAc (50 mL). Pull dry on filter. Yield=19.8 g (79.2%).

Product from the two portions are combined and an XRPD pattern of the combined portions is in FIG. 49 (Example 13).

Example 18—Preparation of Crystalline Forms

Crystalline Form A from Example 5 is used to make the following crystalline forms.

Solvent Method^(a) Observation^(b) Results IPA 1. saturated solution, ambient 1. — A + C 2. cooled in freezer 2. fine irregular, B 1. saturated solution, ambient 1. — B + C 2. cooled in freezer 2. fines, B ^(a)Time and temperature are approximate. ^(b)B = birefringent when observed by polarized light microscopy. 

1-42. (canceled)
 43. A pharmaceutical composition, wherein the pharmaceutical composition comprises 100 mg to 500 mg of Crystalline Form A of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and a pharmaceutically acceptable diluent or carrier, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 5.7, 5.4, 5.2, 4.8, 4.6, 4.3, 3.9, and 3.5.
 44. The pharmaceutical composition of claim 43, wherein the pharmaceutical composition comprises 100 mg to 400 mg of Crystalline Form A.
 45. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 7.2, 6.4, 5.7, 5.4, 5.2, 4.9, 4.8, 4.6, 4.3, 3.9, and 3.5.
 46. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 12.9, 7.2, 6.4, 6.1, 5.7, 5.4, 5.2, 4.9, 4.8, 4.6, 4.4, 4.3, 4.2, 4.1, 3.9, 3.6, 3.5, 3.4, and 3.2.
 47. The pharmaceutical composition of claim 43, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern comprising 2-theta (°) values of 12.3, 13.8, 15.4, 16.6, 17.2, 18.2, 18.5, 19.5, 20.5, 20.7, 22.9, and 25.7, wherein the XRPD is measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å.
 48. The pharmaceutical composition of claim 43, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern comprising 2-theta (°) values of 6.9, 12.3, 13.8, 14.5, 15.4, 16.6, 17.2, 18.2, 18.5, 19.5, 20.1, 20.5, 20.7, 21.0, 21.5, 22.9, 24.7, 25.2, 25.4, 25.7, 26.4, 27.5, and 27.8, wherein the XRPD is measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å.
 49. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å comprising five peaks selected from those shown in FIG.
 1. 50. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å comprising nine peaks selected from those shown in FIG.
 1. 51. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å substantially as shown in FIG.
 1. 52. The pharmaceutical composition of claim 43, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values selected from Table A, B, and C below: TABLE A °2θ d space (Å) Intensity (%) 15.42 ± 0.20 5.741 ± 0.074 26 16.55 ± 0.20 5.352 ± 0.064 40 17.15 ± 0.20 5.167 ± 0.060 29 18.50 ± 0.20 4.792 ± 0.051 100 19.45 ± 0.20 4.560 ± 0.046 38 20.46 ± 0.20 4.338 ± 0.042 43 20.68 ± 0.20 4.291 ± 0.041 80 22.90 ± 0.20 3.880 ± 0.033 22 25.69 ± 0.20 3.466 ± 0.027 70

TABLE B °2θ d space (Å) Intensity (%) 12.26 ± 0.20 7.211 ± 0.117 22 13.78 ± 0.20 6.421 ± 0.093 36 15.42 ± 0.20 5.741 ± 0.074 26 16.55 ± 0.20 5.352 ± 0.064 40 17.15 ± 0.20 5.167 ± 0.060 29 18.19 ± 0.20 4.873 ± 0.053 100 18.50 ± 0.20 4.792 ± 0.051 100 19.45 ± 0.20 4.560 ± 0.046 38 20.46 ± 0.20 4.338 ± 0.042 43 20.68 ± 0.20 4.291 ± 0.041 80 22.90 ± 0.20 3.880 ± 0.033 22 25.69 ± 0.20 3.466 ± 0.027 70

TABLE C °2θ d space (Å) Intensity (%)  6.87 ± 0.20 12.859 ± 0.374  6 12.26 ± 0.20 7.211 ± 0.117 22 13.78 ± 0.20 6.421 ± 0.093 36 14.49 ± 0.20 6.106 ± 0.084 6 15.42 ± 0.20 5.741 ± 0.074 26 16.55 ± 0.20 5.352 ± 0.064 40 17.15 ± 0.20 5.167 ± 0.060 29 18.19 ± 0.20 4.873 ± 0.053 100 18.50 ± 0.20 4.792 ± 0.051 100 19.45 ± 0.20 4.560 ± 0.046 38 20.06 ± 0.20 4.422 ± 0.044 9 20.46 ± 0.20 4.338 ± 0.042 43 20.68 ± 0.20 4.291 ± 0.041 80 20.96 ± 0.20 4.236 ± 0.040 11 21.54 ± 0.20 4.123 ± 0.038 10 22.90 ± 0.20 3.880 ± 0.033 22 24.69 ± 0.20 3.602 ± 0.029 3 25.17 ± 0.20 3.535 ± 0.028 14 25.44 ± 0.20 3.499 ± 0.027 13 25.69 ± 0.20 3.466 ± 0.027 70 26.36 ± 0.20 3.378 ± 0.025 13 27.52 ± 0.20 3.239 ± 0.023 23 27.76 ± 0.20 3.211 ± 0.023 7


53. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å comprising five peaks selected from those shown in FIG. 35, FIG. 37, or FIG.
 47. 54. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å comprising nine peaks selected from those shown in FIG. 35, FIG. 37, or FIG.
 47. 55. The pharmaceutical composition of claim 44, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å substantially as shown in FIG. 35, FIG. 37, or FIG.
 47. 56. A pharmaceutical composition, wherein the pharmaceutical composition comprises 100 mg to 500 mg of Crystalline Form B of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and a pharmaceutically acceptable diluent or carrier, wherein the Crystalline Form B exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 14.6, 5.1, 4.7, 4.6, and 3.6.
 57. The pharmaceutical composition of claim 56, wherein the pharmaceutical composition comprises 100 mg to 400 mg of Crystalline Form B.
 58. The pharmaceutical composition of claim 57, wherein the Crystalline Form B exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 14.6, 6.7, 5.1, 4.7, 4.6, 3.8, 3.7, 3.6, and 3.2.
 59. The pharmaceutical composition of claim 57, wherein the Crystalline Form B exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 14.6, 7.3, 6.7, 6.0, 5.9, 5.5, 5.2, 5.1, 4.9, 4.7, 4.6, 4.5, 4.2, 4.1, 3.9, 3.8, 3.7, 3.6, 3.5, 3.4, 3.3, 3.2, 3.1, and 3.0.
 60. The pharmaceutical composition of claim 57, wherein the Crystalline Form B exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values selected from Table D, E, and F below: TABLE D °2θ d space (Å) Intensity (%)  6.04 ± 0.20 14.620 ± 0.484  13 17.41 ± 0.20 5.089 ± 0.058 14 18.94 ± 0.20 4.681 ± 0.049 79 19.19 ± 0.20 4.622 ± 0.048 100 24.39 ± 0.20 3.646 ± 0.029 23

TABLE E °2θ d space (Å) Intensity (%)  6.04 ± 0.20 14.620 ± 0.484  13 13.21 ± 0.20 6.699 ± 0.101 21 17.41 ± 0.20 5.089 ± 0.058 14 18.94 ± 0.20 4.681 ± 0.049 79 19.19 ± 0.20 4.622 ± 0.048 100 23.59 ± 0.20 3.769 ± 0.032 16 23.79 ± 0.20 3.737 ± 0.031 43 24.39 ± 0.20 3.646 ± 0.029 23 28.15 ± 0.20 3.168 ± 0.022 24

TABLE F °2θ d space (Å) Intensity (%)  6.04 ± 0.20 14.620 ± 0.484  13 12.12 ± 0.20 7.296 ± 0.120 6 13.21 ± 0.20 6.699 ± 0.101 21 14.86 ± 0.20 5.958 ± 0.080 8 15.13 ± 0.20 5.853 ± 0.077 5 16.02 ± 0.20 5.529 ± 0.069 1 16.90 ± 0.20 5.242 ± 0.062 4 17.41 ± 0.20 5.089 ± 0.058 14 18.23 ± 0.20 4.861 ± 0.053 10 18.94 ± 0.20 4.681 ± 0.049 79 19.19 ± 0.20 4.622 ± 0.048 100 19.91 ± 0.20 4.457 ± 0.044 4 21.05 ± 0.20 4.217 ± 0.040 11 21.27 ± 0.20 4.173 ± 0.039 2 21.74 ± 0.20 4.085 ± 0.037 4 22.55 ± 0.20 3.939 ± 0.034 6 23.59 ± 0.20 3.769 ± 0.032 16 23.79 ± 0.20 3.737 ± 0.031 43 24.39 ± 0.20 3.646 ± 0.029 23 25.34 ± 0.20 3.512 ± 0.027 1 26.06 ± 0.20 3.416 ± 0.026 2 26.61 ± 0.20 3.347 ± 0.025 1 27.15 ± 0.20 3.282 ± 0.024 2 28.15 ± 0.20 3.168 ± 0.022 24 28.66 ± 0.20 3.112 ± 0.021 13 29.47 ± 0.20 3.028 ± 0.020 13


61. The pharmaceutical composition of claim 57, wherein the Crystalline Form B exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å comprising five peaks selected from those shown in FIG. 40 or FIG.
 48. 62. The pharmaceutical composition of claim 57, wherein the Crystalline Form B exhibits an X-ray powder diffraction (XRPD) pattern measured using an incident beam of Cu Kα radiation of wavelength 1.54059 Å substantially as shown in FIG. 40 or FIG.
 48. 63. A method for treatment of attention deficit hyperactivity disorder in a patient in need thereof, wherein the method comprises administering to the patient a therapeutically effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises 100 mg to 500 mg of Crystalline Form A of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and a pharmaceutically acceptable diluent or carrier, wherein the Crystalline Form A exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 5.7, 5.4, 5.2, 4.8, 4.6, 4.3, 3.9, and 3.5.
 64. The method of claim 63, wherein the pharmaceutical composition comprises 100 mg to 400 mg of Crystalline Form A.
 65. The method of claim 64, wherein the attention deficit hyperactivity disorder is co-morbid with depression, substance abuse, or anxiety.
 66. The method of claim 65, wherein the attention deficit hyperactivity disorder is co-morbid with substance abuse.
 67. A method for treatment of attention deficit hyperactivity disorder in a patient in need thereof, wherein the method comprises administering to the patient a therapeutically effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises 100 mg to 500 mg of Crystalline Form B of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and a pharmaceutically acceptable diluent or carrier, wherein the Crystalline Form B exhibits an X-ray powder diffraction (XRPD) pattern comprising d-spacing (Å) values of 14.6, 5.1, 4.7, 4.6, and 3.6.
 68. The method of claim 67, wherein the pharmaceutical composition comprises 100 mg to 400 mg of Crystalline Form B.
 69. The method of claim 68, wherein the attention deficit hyperactivity disorder is co-morbid with depression, substance abuse, or anxiety.
 70. The method of claim 69, wherein the attention deficit hyperactivity disorder is co-morbid with substance abuse. 